Houttuynoids AÀE (1À5), a new type of flavonoid with houttuynin tethered to hyperoside, and their presumed biosynthetic precursor hyperoside (6) were isolated from the whole plant of Houttuynia cordata. Their structures were elucidated by analysis of 1D and 2D NMR. A hypothetical biogenetic pathway for houttuynoids AÀE was proposed. Compounds 1À5 exhibited potent anti-HSV (herpes simplex viruses) activity.

Previously, we found that human histocytic lymphoma U937 cells possessed high susceptibility to oridonininduced cell death, but the molecular mechanisms in response to oridonin remain unclear. In this study, U937 cells showed susceptible to apoptosis induced by 27 m mM oridonin and an agonistic anti-Fas IgM mAb (CH-11) (500 ng/ml) as a

Twelve flavonoids, including two new compounds namely plantanones A (1) and B (2), were isolated from the flowers of Hosta plantaginea.

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