Effects of algal toxin okadaic acid on the non-specific immune and antioxidant response of bay scallop (Argopecten irradians)

Cheng, Chunmei; Giri, Sib Sankar; Jun, Jin Woo; Kim, Hyoun Joong; Kim, Sang Wha; Yun, Sukyoung

doi:10.1016/j.fsi.2017.03.031

Cited by 51 publications

(33 citation statements)

References 34 publications

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“…However, the regulatory mechanism of the fluctuation of ACP activity based on different concentrations and exposure times needs to be further confirmed. Moreover, in the present investigation, the ALP activity was increased in scallop Argopecten irradians after exposure to DA, concurrent with Chi et al [25], reporting that 500 nM of okadaic acid (OA) significantly induced ALP activity in bay scallops from 12 to 24 hpe. These results indicate that scallops treated with DA may resist DA exposure through the increased ACP and ALP activities.…”

Section: Discussionsupporting

confidence: 87%

Effects of Marine Toxin Domoic Acid on Innate Immune Responses in Bay Scallop Argopecten irradians

Chi

Zhang

Liu

et al. 2019

JMSE

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Domoic acid (DA) is an amnesic shellfish poisoning toxin produced by some species of the genera Pseudo-nitzschia and Nitzschia. This toxin has harmful effects on various species, especially scallops. This study aimed to investigate the effects of DA exposure on the immune and physical responses of bay scallop, Argopecten irradians. Various immunological and physical parameters were assessed (acid phosphatase (ACP), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxide (LPO), nitric oxide (NO), and the total protein content) in the haemolymph of scallops at 3, 6, 12, 24, and 48 h post-exposure to DA at different concentrations (10, 50, and 100 ng/mL). Moreover, the expression of immune-related genes (CLT-6, FREP, HSP90, MT, PGRP, and PrxV) was assessed. The activities of ACP, ALP, and LDH and the total protein content and LPO increased upon exposure to DA at different concentrations, while NO levels were decreased. Furthermore, immune-related genes were assessed upon DA exposure. Our results showed that exposure to DA negatively impacts immune function and disrupts physiological activities in bay scallops.

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Section: Discussionsupporting

confidence: 87%

Effects of Marine Toxin Domoic Acid on Innate Immune Responses in Bay Scallop Argopecten irradians

Chi

Zhang

Liu

et al. 2019

JMSE

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“…Also, their up-regulation in haemocytes of the oyster C. gigas exposed to A. minutum —a paralytic toxin producer—has been associated with alterations in the immune system [ 43 ]. Similarly, big defensin gene expression was significantly up-regulated in haemolymph of the scallop Argopecten irradians when it was exposed to OA [ 44 ]. However, in a work in which the mussel M. galloprovincialis was exposed to the marine contaminant tris (1-choro-2-propyl) phosphate (TCPP) big defensin was down-regulated, affecting immunocompetence.…”

Section: Discussionmentioning

confidence: 99%

RNA-Seq Analysis for Assessing the Early Response to DSP Toxins in Mytilus galloprovincialis Digestive Gland and Gill

Prego-Faraldo

Martínez

Méndez

2018

Toxins

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The harmful effects of diarrhetic shellfish poisoning (DSP) toxins on mammalian cell lines have been widely assessed. Studies in bivalves suggest that mussels display a resistance to the cytogenotoxic effects of DSP toxins. Further, it seems that the bigger the exposure, the more resistant mussels become. To elucidate the early genetic response of mussels against these toxins, the digestive gland and the gill transcriptomes of Mytilus galloprovincialis after Prorocentrum lima exposure (100,000 cells/L, 48 h) were de novo assembled based on the sequencing of 8 cDNA libraries obtained using an Illumina HiSeq 2000 platform. The assembly provided 95,702 contigs. A total of 2286 and 4523 differentially expressed transcripts were obtained in the digestive gland and the gill, respectively, indicating tissue-specific transcriptome responses. These transcripts were annotated and functionally enriched, showing 44 and 60 significant Pfam families in the digestive gland and the gill, respectively. Quantitative PCR (qPCR) was performed to validate the differential expression patterns of several genes related to lipid and carbohydrate metabolism, energy production, genome integrity and defense, suggesting their participation in the protective mechanism. This work provides knowledge of the early response against DSP toxins in the mussel M. galloprovincialis and useful information for further research on the molecular mechanisms of the bivalve resistance to these toxins.

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“…639 Exposure to okadaic acid has been found to reduce the antioxidant and non-specic immune responses of bay scallops Argopecten irradians. 640 Feeding of a dinophysitoxin-producing microalga (Prorocentrum foraminosum) to Gray's mussel (Crenomytilus grayanus) led to accumulation of dinophysitoxin-1 in the digestive gland and gills while dinophysitoxin-3 levels were highest in the digestive gland. 641 Feeding two strains of the dinoagellate Alexandrium tamarense to uncontaminated mussels Mytilus galloprovincialis led to detection of known and new paralytic shellsh toxins related to saxitoxin.…”

Section: Molluscsmentioning

confidence: 99%

Marine natural products

et al. 2019

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Effects of algal toxin okadaic acid on the non-specific immune and antioxidant response of bay scallop (Argopecten irradians)

Cited by 51 publications

References 34 publications

Effects of Marine Toxin Domoic Acid on Innate Immune Responses in Bay Scallop Argopecten irradians

Effects of Marine Toxin Domoic Acid on Innate Immune Responses in Bay Scallop Argopecten irradians

RNA-Seq Analysis for Assessing the Early Response to DSP Toxins in Mytilus galloprovincialis Digestive Gland and Gill

Marine natural products

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