2020
DOI: 10.1152/japplphysiol.00495.2019
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Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation

Abstract: Age-associated chronic basal inflammation compromises muscle mass and adaptability, but exercise training may exert an anti-inflammatory effect. This investigation assessed basal and exercise-induced inflammation in three cohorts of men: young exercisers [YE; n = 10 men; 25 ± 1 yr; maximal oxygen consumption (V̇o2max), 53 ± 3 mL·kg−1·min−1; quadriceps area, 78 ± 3 cm2; means ± SE], old healthy nonexercisers (OH; n = 10; 75 ± 1 yr; V̇o2max, 22 ± 1 mL·kg−1·min−1; quadriceps area, 56 ± 3 cm2), and lifelong exerci… Show more

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Cited by 110 publications
(87 citation statements)
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References 89 publications
(130 reference statements)
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“…More in-depth functional characterization is necessary to unravel all the protein functions of putatively muscle and bone coupling genes, especially those that have so far not yet been linked to muscle and bone interaction. While this work addresses the difference between untrained versus endurance or resistance-trained healthy subjects, we have to keep in mind that the response of young versus old or healthy versus diseased exercisers may as well be fundamentally different, as it was very recently reported [95]. Table 1.…”
Section: Muscle Secretory Products With Endocrine Functionsmentioning
confidence: 99%
“…More in-depth functional characterization is necessary to unravel all the protein functions of putatively muscle and bone coupling genes, especially those that have so far not yet been linked to muscle and bone interaction. While this work addresses the difference between untrained versus endurance or resistance-trained healthy subjects, we have to keep in mind that the response of young versus old or healthy versus diseased exercisers may as well be fundamentally different, as it was very recently reported [95]. Table 1.…”
Section: Muscle Secretory Products With Endocrine Functionsmentioning
confidence: 99%
“…In human, EP3 and EP4 receptors are expressed in skeletal muscle biopsies of the thigh ( vastus lateralis ), and mostly EP4 expression is associated to anti-inflammation profile in muscle and linked to exercise training ( Lavin et al, 2020 ). These receptors are also described and are more expressed in human skeletal muscle of the leg containing mostly type-1 fibers ( soleus ) ( Liu et al, 2016 ).…”
Section: Bones Joints and Skeletal Musclementioning
confidence: 99%
“…In healthy subjects, there is a clear correlation between the protein synthesis rate and the levels of growth hormones, such as insulin-like growth factor-I (IGF-I) in skeletal muscle [40,41] (Figure 1). In aged muscle, low levels of IGF-I are often accompanied by a high expression of muscle growth inhibitors, including the pro-inflammatory cytokines tumor necrosis factor α and interleukin 6 [42,43]. IGF-I downregulation is also closely associated with enhanced myostatin levels [44][45][46] and reduced DNA/protein synthesis [47].…”
Section: General Considerationmentioning
confidence: 99%