Effects of Aging and Cardiac Denervation on Heart Rate Variability During Sleep

Crasset, Vincent; Mezzetti, Silvia; Antoine, Martine; Linkowski, Paul; Degaute, Jean Paul; Borne, Philippe van de

doi:10.1161/01.cir.103.1.84

Cited by 83 publications

(51 citation statements)

References 36 publications

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“…The HR during the central 6 h of sleep in both conditions was significantly lower in the young than in the middle-aged group. These data agree with the study of Crasset et al (23), which documented that the R-R interval did not differ between young and older subjects during awake periods but was higher in the young than in the older subjects during both rapid eye movement (REM) and non-REM sleep. Goldsmith et al (24) have also reported higher R-R interval values during the night in young men as an expression of vagal predominance during sleep.…”

Section: Discussionsupporting

confidence: 92%

“…Despite this, the established criterion was to analyze intervals with the highest stationary periods of ECG recording during sleep since this condition most likely occurs in the non-REM stages -when there is a shift of cardiac sympathovagal balance, with a corresponding increase in parasympathetic over sympathetic stimulation in the sinus node (23,26,27).…”

Section: Discussionmentioning

confidence: 99%

“…Byrne et al (4) suggested that age per se, and not the reduction in aerobic capacity or the increase in fat usually associated with the aging process, plays the major role in decreasing HRV in older subjects. Also, it has been shown that the decline in HRV with aging is mainly, but not exclusively, due to a decline in parasympathetic tonus (23,30).…”

Section: Discussionmentioning

confidence: 99%

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Effects of aerobic exercise training on heart rate variability during wakefulness and sleep and cardiorespiratory responses of young and middle-aged healthy men

Catai

Chacon-Mikahil

Martinelli

et al. 2002

Braz J Med Biol Res

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The purpose of the present study was to evaluate the effects of aerobic physical training (APT) on heart rate variability (HRV) and cardiorespiratory responses at peak condition and ventilatory anaerobic threshold. Ten young (Y: median = 21 years) and seven middle-aged (MA = 53 years) healthy sedentary men were studied. Dynamic exercise tests were performed on a cycloergometer using a continuous ramp protocol (12 to 20 W/min) until exhaustion. A dynamic 24-h electrocardiogram was analyzed by time (TD) (standard deviation of mean R-R intervals) and frequency domain (FD) methods. The power spectral components were expressed as absolute (a) and normalized units (nu) at low (LF) and high (HF) frequencies and as the LF/HF ratio. Control (C) condition: HRV in TD (Y: 108, MA: 96 ms; P<0.05) and FD -LFa, HFa -was significantly higher in young (1030; 2589 ms 2 /Hz) than in middle-aged men (357; 342 ms 2 /Hz) only during sleep (P<0.05); posttraining effects: resting bradycardia (P<0.05) in the awake condition in both groups; V . O 2 increased for both groups at anaerobic threshold (P<0.05), and at peak condition only in young men; HRV in TD and FD (a and nu) was not significantly changed by training in either groups. The vagal predominance during sleep is reduced with aging. The resting bradycardia induced by short-term APT in both age groups suggests that this adaptation is much more related to intrinsic alterations in sinus node than in efferent vagal-sympathetic modulation. Furthermore, the greater alterations in V . O 2 than in HRV may be related to short-term APT.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of aerobic exercise training on heart rate variability during wakefulness and sleep and cardiorespiratory responses of young and middle-aged healthy men

Catai

Chacon-Mikahil

Martinelli

et al. 2002

Braz J Med Biol Res

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“…Most studies agree that age is inversely associated with RRV (Crasset et al, 2001;Gregoire et al, 1996;Kuo et al, 1999;Tsuji et al, 1996b;Yeragani et al, 1997). The data are less consistent on the impact of sex and race.…”

Section: Introductionmentioning

confidence: 94%

Cardiac autonomic control and the effects of age, race, and sex: The CARDIA study

Sloan

Huang

McCreath

et al. 2008

Autonomic Neuroscience

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“…In human cardiovascular responses to adrenaline, α-adrenergic effects are predominant in female, whereas β-adrenergic effects are predominant in male [7]. Cardiac functions are declined with advancing ageing [8,9]. The decline might be in partial due to age-dependent alterations of the element contents, accompanied with gender differences.…”

Section: Introductionmentioning

confidence: 99%

Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node

Satoh

Tohno

Minami

et al. 2010

Korean J Physiol Pharmacol

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Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day-to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were − 0.178±0.081 (p＜ 0.05) and − 0.088±0.022 (p＜ 0.05) in male (n=30), and − 0.095±0.026 (p＜ 0.05) and − 0.069±0.017 (p＜ 0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca, Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p＜ 0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age-and gender-related SA nodal functions.

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Effects of Aging and Cardiac Denervation on Heart Rate Variability During Sleep

Abstract: Background-Cardiac vagal predominance increases the RR interval and RR high-frequency (HF) variability during non-rapid eye movement (non-REM) sleep (stages I through IV) in young subjects.

Cited by 83 publications

References 36 publications

Effects of aerobic exercise training on heart rate variability during wakefulness and sleep and cardiorespiratory responses of young and middle-aged healthy men

Effects of aerobic exercise training on heart rate variability during wakefulness and sleep and cardiorespiratory responses of young and middle-aged healthy men

Cardiac autonomic control and the effects of age, race, and sex: The CARDIA study

Gender-Related Differences in a Process of the Age-Dependent Alterations of the Elements in Monkey Sino-Atrial Node

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