Effects of age on systemic inflammatory response syndrome and results of coronary bypass surgery

Abstract

SummaryBackgroundCoronary artery bypass (CAB) surgery triggerssystemic inflammatory response syndrome (SIRS) via severalmechanisms. Moreover, age is directly correlated with SIRS.We evaluated the effect of age on SIRS and postoperativeoutcome after CAB surgery.MethodsWe retrospectively reviewed the records of 229 patients who had undergone CAB surgery. The patients were divided into three groups according to age: group 1, < 40 years (n = 61); group 2, 40–75 years (n = 83); and group 3, > 75 years old (n = 85). Pre- and peri-operative data were assessed in all patients. SIRS was diagnosed according to the criteria established by Boehme.ResultsThe average pre-operative EuroSCORE value in group 3 was higher than in the other groups and body surface areas were significantly lower in group 3 than in the other groups (p < 0.05). The postoperative SIRS rates were 68.9% in group 1, 84.3% in group 2 and 91.8% in group 3 (group 1 vs group 3; p < 0.05). Mortality rates were not significantly different between the groups (p > 0.05). The predictive factors for SIRS were age, EuroSCORE rate, on-pump CAB surgery and intra-aortic balloon pump use.ConclusionAge was an important risk factor for SIRS during the postoperative period after CAB.

Factors Affecting Postoperative Mortality in Coronary Bypass Surgery

“…To the Editor: Shroyer and colleagues [1] compared the results of off-pump and on-pump coronary surgery with diabetic patients, of which we read with interest. The systemic inflammatory response, which is a natural result of on-pump coronary artery bypass surgery, may undoubtedly affect the operation results [2]. We agree with Shroyer and associates that it is better to use on-pump surgery because of the comfort and the higher rate of complete revascularization of this technique.…”

“…These supplementary analysis results suggest that the ROOBY-FS (Randomized On/Off Bypass -Follow-up Study) findings-that off pump had an adverse impact on 5-year death in patients with MTD-appear robust [2]. These results may be…”

“…Thank you for the opportunity to respond to the important questions raised by Gokalp and colleagues [1] regarding our article [2]. Before randomization, each ROOBY (Randomized On/Off Bypass) patient's 30-day perioperative morbidity and mortality risk was estimated using the Department of Veterans Affairs Continuous Improvement in Cardiac Surgery Program (CICSP) model [3].…”

Normal Reference Interval of WBC Count After On - Pump Coronary Artery Bypass Graft; When Values Could Be Misleading

“…In a study by Rostami et al, a fever was reported in 29.9% of CABG patients ( 25 ). A fever immediately after cardiopulmonary bypass surgery is associated with cognitive impairment, after CABG ( 26 , 27 ), which potentially could be considered as a sepsis sign itself.…”

The Significance of Simple Inflammatory Markers in Off Pump Surgery—Review

“…Activated platelets in turn release neutrophils activators such as Il-6 and Il-8 [91]. OPCAB technique allows to limit inflammatory activation [92] which occurs in 70-90% patients undergoing conventional coronary artery bypass grafting with cardiopulmonary bypass (on-pump) [93]. Systemic inflammatory reactions secondary to on-pump procedures represent the significant risk factor for postoperative multiple organ dysfunction (MOD) [94].…”