The Significance of Simple Inflammatory Markers in Off Pump Surgery—Review

Urbanowicz, Tomasz; Olasińska-Wiśniewska, Anna; Gładki, Marcin; Jemielity, Marek

doi:10.31083/j.rcm2312400

Cited by 1 publication

(2 citation statements)

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“…A number of studies have demonstrated that the level of neutrophils, lymphocytes, and platelets plays an important role in the development of chronic inflammation and the progression of cardiovascular diseases. In some studies, biomarkers such as C-reactive protein, NLR, and PLR demonstrated their prognostic values for the risk of postoperative complications and mortality [ 15 , 16 , 17 ]. For example, in the study by Russu E. et al, the preoperative role of NLR and PLR in the medium-term outcome of patients surgically revascularized for femoropopliteal disease was studied.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the possibility of using the SII as a predictor of unfavorable outcomes among patients with acquired heart defects was actively investigated. This marker of systemic inflammation takes into account the level of neutrophils, platelets, and lymphocytes, thereby reflecting both inflammatory and immunological activation, as well as activation of the coagulation cascade [ 17 ]. The SII was studied in patients with chronic heart failure, neoplasms, and nervous system disorders [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

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The Role of «Novel» Biomarkers of Systemic Inflammation in the Development of Early Hospital Events after Aortic Valve Replacement in Patients with Aortic Stenosis

Shvartz,

Sokolskaya,

Ispiryan

et al. 2023

Life

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Introduction. The pathogenesis of aortic stenosis includes the processes of chronic inflammation, calcification, lipid metabolism disorders, and congenital structural changes. The goal of our study was to determine the predictive value of novel biomarkers of systemic inflammation and some hematological indices based on the numbers of leukocytes and their subtypes in the development of early hospital medical conditions after mechanical aortic valve replacement in patients with aortic stenosis. Materials and methods. This was a cohort study involving 363 patients who underwent surgical intervention for aortic valve pathology between 2014 and 2020. The following markers of systemic inflammation and hematological indices were studied: SIRI (Systemic Inflammation Response Index), SII (Systemic Inflammation Index), AISI (Aggregate Index of Systemic Inflammation), NLR (Neutrophil/Lymphocyte Ratio), PLR (Platelet/Lymphocyte Ratio), and MLR (Monocyte/Lymphocyte Ratio). Associations of the levels of these biomarkers and indices with the development of in-hospital death, acute kidney injury, postoperative atrial fibrillation, stroke/acute cerebrovascular accident, and bleeding were calculated. Results. According to an ROC analysis, an SIRI > 1.5 (p < 0.001), an SII > 718 (p = 0.002), an AISI > 593 (p < 0.001), an NLR > 2.48 (p < 0.001), a PLR > 132 (p = 0.004), and an MLR > 0.332 (p < 0.001) were statistically significantly associated with in-hospital death. Additionally, an SIRI > 1.5 (p < 0.001), an NLR > 2.8 (p < 0.001), and an MLR > 0.392 (p < 0.001) were associated with bleeding in the postoperative period. In a univariate logistic regression, SIRI, SII, AISI, and NLR were statistically significant independent factors associated with in-hospital death. In a multivariate logistic regression model, SIRI was the most powerful marker of systemic inflammation. Conclusion. SIRI, SII, AISI, and NLR as novel biomarkers of systemic inflammation were associated with in-hospital mortality. Of all markers and indices of systemic inflammation in our study, SIRI was the strongest predictor of a poor outcome in the multivariate regression model.

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Section: Discussionmentioning

confidence: 99%