Effects of Age on Plasma Matrix Metalloproteinases (MMPs) and Tissue Inhibitor of Metalloproteinases (TIMPs)

Bonnema, D. Dirk; Webb, Carson S.; Pennington, Weems R.; Stroud, Robert E.; Leonardi, Amy E.; Clark, Leslie L.; McClure, Catherine; Finklea, Laura; Spinale, Francis G.; Zile, Michael R.

doi:10.1016/j.cardfail.2007.04.010

Cited by 144 publications

(113 citation statements)

References 56 publications

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“…Cell culture studies have indicated that TGF-β inhibits mitotic growth of cardiomyocytes, and stimulates hypertrophic growth, fibrosis and re-expression of the fetal isoforms of myofibrillar protein genes (11). Experimental studies have demonstrated that age-related cardiac fibrosis and atherosclerosis are strongly associated with myocardial extracellular matrix (ECM) (12), and TGF-β is known to play a significant role in fibrotic cardiac remodeling and multiple factors altered in the aging heart.…”

Section: Discussionmentioning

confidence: 99%

Investigation of thrombospondin-1 and transforming growth factor-β expression in the heart of aging mice

Cai

Yuan

Fei

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. Elderly patients face the problems of morbidity and mortality due to age-mediated disabilities. The purpose of the present study was to investigate the expression of thrombospondin-1 (TSP-1) and transforming growth factor-β (TGF-β) in aging mice, and its probable mechanism in the pathological changes of aging myocardium. The aging model group (AM) comprised 30-month-old mice, while the control group comprised 2-month-old mice. The pathological changes were explored by H&E staining, and the contents of superoxide dismulase (SOD) and malondialdehyde (MDA) in the hearts were determined by xanthine oxidation or TBA colorimetry. TSP-1 and TGF-β expression in the left ventricular myocardium was also measured by immunohistochemistry. The results showed that the activities of SOD decreased and the MDA content increased markedly in the hearts of the AM group compared to the control group. H&E staining showed that the control group myocardial cells lined up in order with clear structure and stained equably, while the AM group myocardial cells lined up in disorder with an augmented cell body and the appearance of many granules and interstitial fibrosis. Compared to the control group, in the hearts of the AM group, TSP-1 and TGF-β protein expression in myocardial cells showed a significant increase (P<0.01). TSP-1 and TGF-β expression increased in the myocardium, which may be related to pathological changes of age-related heart diseases, such as hypertrophy, fibrosis of myocardial cells and microvessel dissepiment thickening.

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Section: Discussionmentioning

confidence: 99%

Investigation of thrombospondin-1 and transforming growth factor-β expression in the heart of aging mice

Cai

Yuan

Fei

et al. 2011

Experimental and Therapeutic Medicine

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“…A strong relationship between serum levels of MMP9 and the process of inflammation characterized by hsCRP has been shown in acute coronary syndromes (9,11).…”

Section: Introductionmentioning

confidence: 98%

Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome

Goto

Chiba

Matsuura

et al. 2016

IRDR

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“…85 It was found that age correlated directly with increased MMP2, MMP7, tissue inhibitor of metalloproteinase 1 (TIMP-1), TIMP-2, and TIMP-4 while MMP9 concentration decreased with age. 86 mRNA levels of MMP2 and MMP9, as well as MMP2 and MMP9 activity, increased with age in tendons. 87 Cartilage undergoes extensive modifications with age.…”

Section: Compositional Changes With Age and Potential Influence On Msmentioning

confidence: 99%

Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies

Lynch

Pei²

2014

Organogenesis

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A recent paper demonstrated that decellularized extracellular matrix (DECM) deposited by synovium-derived stem cells (SDSCs), especially from fetal donors, could rejuvenate human adult SDSCs in both proliferation and chondrogenic potential, in which expanded cells and corresponding culture substrate (such as DECM) were found to share a mutual reaction in both elasticity and protein profiles (see ref.

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Effects of Age on Plasma Matrix Metalloproteinases (MMPs) and Tissue Inhibitor of Metalloproteinases (TIMPs)

Cited by 144 publications

References 56 publications

Investigation of thrombospondin-1 and transforming growth factor-β expression in the heart of aging mice

Investigation of thrombospondin-1 and transforming growth factor-β expression in the heart of aging mice

Inflammageing assessed by MMP9 in normal Japanese individuals and the patients with Werner syndrome

Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies

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