Effects of age, gender, and lifestyle factors on plasma apolipoprotein A-IV concentrations

Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4α, and PGC-1α

“…Together, these results indicate that the induction of apoA-IV expression that occurs in fasting or diabetes entails a common glucocorticoid-dependent mechanism. Consistent with these in vivo findings in mice, apoA-IV protein levels are increased in diabetic patients (49).…”

Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet

“…A weak independent correlation of plasma apoA-IV with apoA-I has been observed previously and may reflect the association of the two apo's on LpA-I:A-IV particles. 23 A significant correlation between apoA-IV and fasting plasma TG has been reported, but was not confirmed in this and in other studies. 4,17,33,34 The reasons for these conflicting results remain unclear.…”

“…A weak positive correlation of plasma apoA-IV with BMI (r ¼ 0.17, Po0.05) was observed in a large group of middle-aged women. 23 In the present study, the marked reduction of plasma apoA-IV occurring during weight reduction did not correlate with the changes of RBMI or plasma leptin levels. This suggests that the decrease of plasma apoA-IV was not a direct effect of the reduction of body fat mass.…”

MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study

“…Experimental studies in isolated pancreatic islets and Apoa4 knockout mice have already demonstrated that ApoA-IV has a glucose-lowering effect [40,41]. Interestingly, consistent with two small type 2 diabetes studies, individuals with manifest type 2 diabetes had increased ApoA-IV levels in our study, [42,43]. However, a sensitivity analysis which we conducted showed that ApoA-IV levels were not increased in diabetic individuals who did not take glucose-lowering medication.…”