Effects of Age and Parental History of Alcoholism on EEG Findings in Mission Indian Children and Adolescents

Ehlers, Cindy L.; Wall, Tamara L.; Garcia‐Andrade, Consuelo; Phillips, Evelyn

doi:10.1111/j.1530-0277.2001.tb02266.x

Cited by 29 publications

(4 citation statements)

References 81 publications

(69 reference statements)

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“…The P300 amplitude decrements do not recover with abstinence (Porjesz and Begleiter, 1985), and therefore suggesting that reduced P300 amplitude antecedes the development of alcoholism. The P300 amplitude reduction has been replicated under different experimental conditions, with and without alcohol administration, in both older and younger subjects at risk, in male and female offspring and in subjects of different ethnicities (Begleiter et al, 1987;Benegal et al, 1995;Berman et al, 1993;Cohen et al, 1997;Ehlers et al, 2003;Ehlers et al, 2001;Hill and Steinhauer, 1993;Kamarajan et al, 2005b;O′Connor et al, 1986;O′Connor et al, 1987;Porjesz and Begleiter, 1990;Ramachandran et al, 1996;Ratsma et al, 2001;Rodriguez Holguin et al, 1999;Steinhauer and Hill, 1993;Van der Stelt et al, 1998). The lowered P300 amplitude observed in clinical sample of alcoholics has also been established in community samples .…”

Section: Introductionmentioning

confidence: 66%

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy

Jones

Porjesz

et al. 2007

International Journal of Psychophysiology

117

136

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Background-Visual P300 is consistently lower in alcohol dependent individuals, their offspring and subjects at risk. Delta and theta event related oscillations (ERO) are the major contributors to the P300 signal. The total and evoked power in delta and theta bands in the 300 to 700 millisecond post-stimulus window (corresponding to the zone of P3 maxima) was compared between adolescent offspring of alcoholics (high-risk) and age-matched normal controls (low-risk), to assess the utility of the risk markers.Methods-EEG was recorded during the performance of visual oddball task. The S-Transform algorithm decomposed the EEG signals into different frequency bands and the group differences in total and evoked power in the oscillatory responses during the P300 time window (300 to 700 ms) were analyzed using a multivariate design. Similar analysis was performed on P300 peak amplitudes for the target.Results-The high-risk group showed significantly lower parietal post-stimulus evoked and total power in the delta band for targets. A decrease in total power was seen centrally and parietally in theta band. The P300 peak amplitude in the parietal electrodes was also significantly lower in the high-risk group.Conclusions-The decreased total theta power and total and evoked delta power for visual targets in high risk individuals may serve as an endophenotypic marker in the development of alcoholism and other disinhibitory disorders. The differences seen between the offspring of alcoholics and controls may have a cholinergic basis. The ERO measures appear to be more robust than the P300 amplitude in differentiating the groups.

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Section: Introductionmentioning

confidence: 66%

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy

Jones

Porjesz

et al. 2007

International Journal of Psychophysiology

117

136

View full text Add to dashboard Cite

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“…The data came from a long-running study exploring risk factors for mental and physical health in a community sample of American Indian children, adolescents, and adults (Ehlers et al, 2001a(Ehlers et al, , 2001b(Ehlers et al, , 2001c(Ehlers et al, , 2001d(Ehlers et al, , 2004a(Ehlers et al, , 2004b(Ehlers et al, , 2008(Ehlers et al, , 2012(Ehlers et al, , 2017Ehlers & Gizer, 2013;Gilder et al, 2004Gilder et al, , 2006Gilder et al, , 2007Gilder et al, , 2009. American Indian participants were recruited from eight geographically contiguous reservations with a total population of about 3,000 individuals.…”

Section: Participantsmentioning

confidence: 99%

Social zeitgeber and sleep loss as risk factors for suicide in American Indian adolescents

Ehlers,

Gilder,

Benedict

et al. 2024

Transcult Psychiatry

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American Indians / Alaska Natives (AI/AN) bear a high burden of suicide, the reasons for which are not completely understood, and rates can vary by tribal group and location. This article aims to identify circumstances reported by a community group of American Indian adolescent participants to be associated with their depression and/or suicide. American Indian adolescents (n = 360) were recruited from contiguous reservations and were assessed with a semi-structured diagnostic interview. Twenty percent of the adolescents reported suicidal thoughts (ideation, plans), an additional 8% reported a history of suicide attempts, and three deaths due to suicide were reported. Suicidal behaviors and major depressive disorder (MDD) co-occurred and were more common among female adolescents. The distressing events that adolescents most often reported were: death in the family, family disruption, peer relationship problems, and school problems. All of these events were significantly associated with suicidal behaviors, however those with suicidal acts were more likely to report death in the family. Those with MDD but no suicidal behaviors were more likely to report disruptions in the family. Disruptions in falling asleep were also associated with suicidal behaviors and having experienced a death in the family. Disruptions in important relationships, particularly through death or divorce, may be interpreted as a loss or disruption in “social zeitgebers” that may in turn disturb biological rhythms, such as sleep, thus potentially increase the risk for MDD and/or suicide. Prevention programs aimed at ameliorating the impact of disruptions in important relationships may potentially reduce suicidal behaviors in AI/AN adolescents.

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“…Other severe EEG abnormalities such as epileptiform signs [48] and stress exposure have also been underestimated in at-risk populations. Several neuropsychological and EEG features have proven to have a high sensitivity to indicate a possible neurophysiological decline in conditions such as Parkinson's disease [49], autism [50], epilepsy [51], parental history of alcohol consumption [52], as well as cognitive impairment in areas such as memory, attention, language, and school success [53].…”

Section: Eeg In Children At Neurodevelopmental Riskmentioning

confidence: 99%

Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review

Galindo-Aldana,

Torres-González

2023

Pediatric Reports

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Children from rural areas face numerous possibilities of neurodevelopmental conditions that may compromise their well-being and optimal development. Neuropsychology and electroencephalography (EEG) have shown strong agreement in detecting correlations between these two variables and suggest an association with specific environmental and social risk factors. The present scoping review aims to describe studies reporting associations between EEG features and cognitive impairment in children from rural or vulnerable environments and describe the main risk factors influencing EEG abnormalities in these children. The method for this purpose was based on a string-based review from PubMed, EBSCOhost, and Web of Science, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Qualitative and quantitative analyses were conducted from the outcomes that complied with the selected criteria. In total, 2280 records were identified; however, only 26 were eligible: 15 for qualitative and 11 for quantitative analysis. The findings highlight the significant literature on EEG and its relationship with cognitive impairment from studies in children with epilepsy and malnutrition. In general, there is evidence for the advantages of implementing EEG diagnosis and research techniques in children living under risk conditions. Specific associations between particular EEG features and cognitive impairment are described in the reviewed literature in children. Further research is needed to better describe and integrate the state of the art regarding EEG feature extraction.

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Effects of Age and Parental History of Alcoholism on EEG Findings in Mission Indian Children and Adolescents

Cited by 29 publications

References 81 publications

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Social zeitgeber and sleep loss as risk factors for suicide in American Indian adolescents

Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review

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