Effects of age and oligoasthenozoospermia on telomeres of sperm and blood cells

Balmori, Carlos; Córdova-Oriz, Isabel; Alba, Guillermo De; Medrano, Marta; Jiménez-Tormo, Laura; Polonio, Alba M.; Chico-Sordo, Lucía; Pacheco, A.; García-Velasco, Juan A.; Varela, Elisa

doi:10.1016/j.rbmo.2021.10.010

Cited by 11 publications

(12 citation statements)

References 71 publications

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“…The evaluation of telomeres could be considered a biomarker of spermatogenesis, sperm quality, and related male infertility. Balmori et al (2022) reported statistically significant positive correlations between sperm count ( p = .009) and motility ( p = .007) and sperm TL only in younger male. They suggested that at younger ages, longer TL in spermatozoa have better seminal parameters.…”

Section: Discussionmentioning

confidence: 92%

“…In agreement with Balmori et al (2022) , our study evaluated the sperm from couples undergoing IVF. The mean age of the male partner was 36.8 ± 7.5 years.…”

Section: Discussionmentioning

confidence: 99%

“… Balmori et al (2022) evaluated the difference in T/L between old and young men with normal and oligoasthenospermia. They reported a significantly positive correlation between sperm TL and sperm count and motility in younger men with normal sperm.…”

Section: Discussionmentioning

confidence: 99%

“…As opposed to Balmori et al (2022), the study by Ribas-Maynou et al ( 2022) on pig's sperm reported that TL was not correlated to sperm quality variables including viability, morphology, and DNA fragmentation. Moreover, they noted that regardless of the equivalent sperm parameters between TL groups, the blastulation rate was significantly better in the longer telomere group.…”

Section: Telomere Length and Sperm Parametersmentioning

confidence: 96%

“…Although the role of sperm TL is not clearly known, the high activity of telomerase reverse transcriptase (TERT), the catalytic subunit of the telomerase in germ cells (Riou et al, 2005), and the death of sperm stem cells with shortened TL (Eisenberg et al, 2012) both enable the selection of a subset of sperm with longer telomeres. Balmori et al (2022) evaluated the difference in T/L between old and young men with normal and oligoasthenospermia. They reported a significantly positive correlation between sperm TL and sperm count and motility in younger men with normal sperm.…”

Section: Lifestyle and Telomere Lengthmentioning

confidence: 99%

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The Impact of Lifestyle on Sperm Function, Telomere Length, and IVF Outcomes

et al. 2022

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Many risk factors can potentially influence sperm quality. Telomeres confer stability on the chromosome and their dysfunction has been implicated in conditions such as cancer, aging, and lifestyle. The impact of lifestyle on sperm cell telomeres is unclear. The objectives of this study were to evaluate the impact of lifestyle behaviors on telomere length in sperm and to follow the correlation with pregnancy outcomes in patients undergoing in vitro fertilization (IVF). In this prospective observational study, sperm was analyzed for telomere length (TL). Men were asked to report lifestyle behaviors including occupation (physical or sedentary), smoking duration and amount, physical activity, dietary habits, and where they keep their cellular phone (bag, pants, or shirt pocket). Correlations among semen analysis, TL, men’s habits, and embryo quality and pregnancy outcomes were evaluated. Among 34 patients recruited, 12 had longer TL and 13 shorter TL. Sperm motility was negatively correlated with TL (Pearson correlation = −.588, p = .002). Smoking adversely affected native sperm motility (53% motility in nonsmokers vs. 37% in smokers; p = .006). However, there was no significant impact on TL. The group with longer telomeres demonstrated significant association with healthy diet (10/12 vs. 6/13; p = .05) and a trend toward more sports activity, weekly (16/84 vs. 7/91; p = .04) compared with the shorter telomeres group. This study suggests that lifestyle, healthy diet, and sports activity are associated with long telomeres in sperm. Sperm quality is also influenced by patients’ habits. The study strongly recommends maintaining a healthy lifestyle to preserve general health and fertility.

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Section: Discussionmentioning

confidence: 92%

“…In agreement with Balmori et al (2022) , our study evaluated the sperm from couples undergoing IVF. The mean age of the male partner was 36.8 ± 7.5 years.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Telomere Length and Sperm Parametersmentioning

confidence: 96%

Section: Lifestyle and Telomere Lengthmentioning

confidence: 99%

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The Impact of Lifestyle on Sperm Function, Telomere Length, and IVF Outcomes

et al. 2022

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Evaluation of telomere length, reactive oxygen species, and apoptosis in spermatozoa of patients with oligospermia

Margiana,

Gupta,

Al‐Jewari

et al. 2024

Cell Biochemistry & Function

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Abstract50% of cases of infertility are caused by male factor, which acquired or congenital problems may bring on. Male infertility can be caused by oligospermia and asthenozoospermia, which are common. Since the same mutations that cause azoospermia in some people also cause oligozoospermia in others, oligozoospermia may be thought of as a less severe form of azoospermia. Studies have demonstrated telomere length, catalase activity, super oxide dismutase (SOD), and DNA fragmentation can be influential factors for male infertility. The amount of apoptosis, oxidative stress factors, telomere length, and DNA fragmentation were some aspects of healthy sperm that we chose to look into in this study and compare to oligospermia individuals. Oligospermia patients (n = 24) and fertile men (n = 27) semen samples were collected, and the apoptosis rate of sperms in both groups was analyzed (Flow cytometry). Also, gene expression of apoptotic and antiapoptotic markers and telomere length were examined (real‐time polymerase chain reaction). The sperm DNA fragmentation kit was used to determine DNA fragmentation and to evaluate catalase and SOD activity; the specific kits and methods were utilized. Higher expression levels of caspase3 (p = .0042), caspase8 (p = .0145), caspase9 (p = .0275), and BAX (p = .0202) mRNA were observed in patients who had oligospermia. In contrast, lower mRNA expression of BCL‐2 (p = .0009) was detected in this group. In addition, telomere length was decreased in the oligospermia group (p < .0001) compared to the health group. Moreover, the frequency of apoptosis is induced in patients (p = .0026). The catalase activity is low (p = .0008), but the SOD activity is high (p = .0015) in the patient group. As a result of our findings, we may list the sperm cell apoptosis rate, telomere length, the degree of sperm DNA fragmentation, and lastly, the measurement of significant and efficient oxidative stress markers like SOD and catalase in semen plasma among the principal diagnostic characteristics for oligospermia. Future studies will be better able to treat oligospermia by showing whether these indicators are rising or falling.

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