Effects of Aflatoxin on Liver and Protective Effectiveness of Esterified Glucomannan in Merino Rams

Çolakoğlu, Fatma; Dönmez, Hasan Hüseyin

doi:10.1100/2012/462925

Cited by 18 publications

(16 citation statements)

References 26 publications

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“…In this study, a 7.7-fold increase in the lesional score was observed in AFB 1 -exposed animals. Notably, this study constitutes the first evaluation of the effects of a subclinical, single AFB 1 exposure in mice, and the hepatic lesions observed here are consistent with those observed in other studies that used different doses or frequencies of exposure [ 21 ].…”

Section: Discussionsupporting

confidence: 89%

Impact of a Single Oral Acute Dose of Aflatoxin B1 on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice

Ishikawa

Hirooka

Silva

et al. 2017

Toxins

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Aflatoxin B1 (AFB1), a mycotoxin found in food and feed, exerts harmful effects on humans and animals. The liver is the earliest target of AFB1, and its effects have been evaluated in animal models exposed to acute or chronic doses. Considering the possibility of sporadic ingestion of AFB1-contaminated food, this study investigated the impact of a single oral dose of AFB1 on liver function/cytokines and the lymphoproliferative response in mice. C57BL/6 mice were treated with a single oral AFB1 dose (44, 442 or 663 μg AFB1/kg of body weight) on the first day. Liver function (ALT, γ-GT, and total protein), cytokines (IL-4, IFN-γ, and IL-17), histopathology, and the spleen lymphoproliferative response to mitogens were evaluated on the 5th day. Although AFB1 did not produce any significant changes in the biochemical parameters, 663 μg AFB1/kg-induced hepatic upregulation of IL-4 and IFN-γ, along with liver tissue injury and suppression of the lymphoproliferative response to ConA (p < 0.05). In conclusion, a single oral dose of AFB1 exposure can induce liver tissue lesions, liver cytokine modulation, and immune suppression in C57BL/6 mice.

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Section: Discussionsupporting

confidence: 89%

Impact of a Single Oral Acute Dose of Aflatoxin B1 on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice

Ishikawa

Hirooka

Silva

et al. 2017

Toxins

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“…The microscopic alterations in liver samples with lower levels were mostly in the form of congestion in the sinusoidal and central vein, hepatocytic steatosis and fatty vacuolations, vacuolar to hydrobic degenerations and haemosidrine pigments. Nearly similar histopathology alterations were previously reported in some studies for aflatoxicosis in other species as these of Colakoglu and Donmez (2012) in Rams, Smith et al (1976) in farm animals, Armbrecht et al (1970) in sheep, Miller et al (1984) in goats, Hinton et al (2003) in rat and Ortatatli et al (2005) in broilers.…”

Section: Discussionsupporting

confidence: 67%

Effect of Aflatoxin B1 (AFB1) Residues on the Pathology of Camel Liver

Al-Hiza¹,

Al-Ga²,

Barak³

2015

Asian J. of Animal and Veterinary Advances

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This study was carried out to evaluate the potential effect of high Aflatoxin B1 (AFB1) residues on the pathology of livers of camels slaughtered at different abattoirs in AL-Ahsa region, Kingdom of Saudi Arabia. Aflatoxin residues were determined in a total number of 160 camel liver samples. Thirty seven (23.1%) liver samples showed residues of AFB1 higher than the standard permissible limit (spl. 0.05 ppb). Seventeen of these samples contained very high residues between 0.1-1.0 ppb. while twenty samples contained residues between 0.05-0.1 ppb. However, 123 (76.9%) liver samples showed AFB1 residues less than the standard permissible limits (spl). Small portions of the liver tissue from all animals were removed, weighed and preserved in 10% formalin solution and then embedded in paraffin wax. Pathological changes were observed in the liver tissues collected from all camels. Liver samples containing high AFB1 residues showed remarkable gross changes including fatty degeneration with variable areas of petechial hemorrhages, Congestion, fibrosis and large whitish focus of necrosis. However, mild gross changes were obtained in the liver samples containing medium AFB1 residues, between (0.05->0.1 ppb.) and no gross changes were obtained in the liver samples containing AFB1 residues bellow the standard permissible limits (spl). In addition the histopathological changes in the liver samples with high residues of AFB1 showed vacuolar degenerations, cholangitis, cirrhosis, bile duct carcinoma and hepatocellular carcinoma while hepatocytic fatty vacuolation, hydropic degeneration, congestion and mild degree of peribiliary cirrhosis were observed in the liver samples containing medium, AFB1 residues and no remarkable changes were seen in the liver samples containing AFB1 residues below the standard permissible limits (spl). These results revealed that aflatoxin residues may cause massive histopathological changes to the liver tissue of camels and caution should be exhibited in its use for human and animal consumption.

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“…The increase of liver relative weight in present study is supported by the histopathological finding which had been shown the severe inflammation in both perilobular and interlobular area, degeneration and bile duct proliferation (P<0.05) ( Table 3). The liver hepatocytes play an essential role in the detoxification of the toxin and xenobiotics (Colakoglu and Donmez, 2012). High accumulation of the toxin promotes the degeneration (Figure 1a) that is induced by the oxidative stress and impairment of cellular metabolism (Guo et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Recent Update: Effects of Aflatoxin in Broiler Chickens

Kurniasih¹,

Prakoso²

2019

jwpr

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Aflatoxin is a worldwide problem in poultry industries as it is known to contaminate poultry feed. Aflatoxin induces stress and increases mortality rate during infection in poultry, especially broiler chickens. The objectives of this study was to observe the pathological effects due to aflatoxicosis in broiler chickens. A total of 120 chickens were divided into four groups, group A fed with a basal diet without aflatoxin contamination, group B with aflatoxin (> 1 ppb < 50 ppb), group C with aflatoxin (> 51 ppb < 100 ppb), group D with aflatoxin (> 101 ppb < 150 ppb). The data were collected and analysed on day 7, 14, and 21. The results showed that diet with high aflatoxin contamination in group D impaired the physical and laboratory performances of the chickens, increased the risk of residue in the poultry's final products. The varying doses of aflatoxin contamination in the chicken feed causes the problems on the broiler chickens with different level of severity.

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Effects of Aflatoxin on Liver and Protective Effectiveness of Esterified Glucomannan in Merino Rams

Cited by 18 publications

References 26 publications

Impact of a Single Oral Acute Dose of Aflatoxin B1 on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice

Impact of a Single Oral Acute Dose of Aflatoxin B1 on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice

Effect of Aflatoxin B1 (AFB1) Residues on the Pathology of Camel Liver

Recent Update: Effects of Aflatoxin in Broiler Chickens

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