Effects of aerobic exercise training on ACE and ADRB2 gene expression, plasma angiotensin II level, and flow-mediated dilation: a study on obese postmenopausal women with prehypertension

Azadpour, Noushin; Tartibian, Bakhtyar; Koşar, Şükran Nazan

doi:10.1097/gme.0000000000000762

Cited by 32 publications

(53 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 In other words, aerobic exercise-induced cardiovascular system adaptations can be accompanied by a better quality of life and decreased cardiovascular diseases in sedentary post-menopausal women. 3,9 In addition, moderate-intensity aerobic exercise provides changes in the heart that contribute to the greater peak Q and aerobic capacity. Changes in cardiac dimensions and blood volume play the primary role in enhancing SV, and hence Q.…”

Section: Discussionmentioning

confidence: 99%

“…9 In another study, we reported that the aerobic exercise training created a suitable level of fitness, thereby can affect the aging process. 3,9,10 In other words, moderateintensity aerobic exercise is one of the most effective ways of reducing risk factors for cardiovascular disease and mortality. 9,10 Thus, the first purpose of this study was to examine the effect of 12 weeks of the protocol; warm up-walking and jogging moderate-intensity aerobic exercise programrecovery (W-WJMIAEP-R) on ECG indices, including heart rate, cardiac waves, and cardiac segments & intervals in post-menopausal women.…”

mentioning

confidence: 97%

“…8 In contrast, our recent studies showed that the regular aerobic exercise produces phenotypic and genotypic changes and/or anatomical and physiological adaptations in the cardiovascular system, especially the growth of myocyte cells which is considered as a nonpharmacological adaptation against cardiovascular disease. 3,9 Also, the beneficial effects of aerobic exercise training in lowering BP are observable at the molecular level in prehypertensive post-menopausal women. 9 In another study, we reported that the aerobic exercise training created a suitable level of fitness, thereby can affect the aging process.…”

mentioning

confidence: 99%

“…3,9 Also, the beneficial effects of aerobic exercise training in lowering BP are observable at the molecular level in prehypertensive post-menopausal women. 9 In another study, we reported that the aerobic exercise training created a suitable level of fitness, thereby can affect the aging process. 3,9,10 In other words, moderateintensity aerobic exercise is one of the most effective ways of reducing risk factors for cardiovascular disease and mortality.…”

mentioning

confidence: 99%

“…3,9,10 In other words, moderateintensity aerobic exercise is one of the most effective ways of reducing risk factors for cardiovascular disease and mortality. 9,10 Thus, the first purpose of this study was to examine the effect of 12 weeks of the protocol; warm up-walking and jogging moderate-intensity aerobic exercise programrecovery (W-WJMIAEP-R) on ECG indices, including heart rate, cardiac waves, and cardiac segments & intervals in post-menopausal women. The second aim was to examine the effect of five months of detraining on ECG indices in post-menopausal women.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Assessment of Electrocardiogram Indices in Postmenopausal Women: Effects of Aerobic Exercise and Detraining

Tartibian

Afsargharehbagh

Malandish

et al. 2018

Int J Basic Sci Med

Self Cite

View full text Add to dashboard Cite

Introduction: electrocardiogram (ECG) indices as a valuable tool for the diagnosis depolarization and repolarization of the myocardium are affected by aerobic exercise and detraining. The purpose of this study was to investigate the effects of 12-week moderate-intensity aerobic exercise and 5 months detraining on electrocardiogram (ECG) indices in post-menopausal women. Methods: Twenty-four post-menopausal women aged 50-70 years were randomly assigned to Exercise (E, n=12) and Control (C, n=12) groups. E group performed of 12 weeks moderate-intensity aerobic exercise program (W-WJMIAEP-R), and then 5 months detraining remained, but the C group participated in no intervention during 8-month. The ECG indices were measured at baseline, after 12-week exercise, and after 5-month detraining. Results: After 12-week in between-groups, ECG indices were not significantly different (P>0.05), except P-R interval (P≤0.05). After 5-month detraining in between-groups were not a significant difference for dependent variables (P>0.05), except P-R segment and S-T interval (P≤0.05). Conclusion: The Results suggest that 12 weeks of W-WJMIAEP-R increases P-R interval in sedentary post-menopausal women that is likely to be effective in preventing heart arrhythmias. The P-R segment and S-T interval decreased significantly after 5 months detraining period that 12 weeks W-WJMIAEP-R induced-ECG positive adaptations such as decrease P-R segment and S-T interval are maintained even after 5-month detraining and consequently prevents the increase in atrial aging process in postmenopausal women.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Assessment of Electrocardiogram Indices in Postmenopausal Women: Effects of Aerobic Exercise and Detraining

Tartibian

Afsargharehbagh

Malandish

et al. 2018

Int J Basic Sci Med

Self Cite

View full text Add to dashboard Cite

show abstract

Exercise and the Endothelium

Tremblay

Pyke

2019

Cardiorespiratory Fitness in Cardiometabolic Diseases

View full text Add to dashboard Cite

Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians

Afsar,

Caliskan

et al. 2024

Mol Cell Biochem

View full text Add to dashboard Cite

Renin angiotensin system (RAS) alters various mechanisms related to muscle wasting. The RAS system consists of classical and non-classical pathways, which mostly function differently. Classical RAS pathway, operates through angiotensin II (AngII) and angiotensin type 1 receptors, is associated with muscle wasting and sarcopenia. On the other hand, the non-classical RAS pathway, which operates through angiotensin 1–7 and Mas receptor, is protective against sarcopenia. The classical RAS pathway might induce muscle wasting by variety of mechanisms. AngII reduces body weight, via reduction in food intake, possibly by decreasing hypothalamic expression of orexin and neuropeptide Y, insulin like growth factor-1 (IGF-1) and mammalian target of rapamycin (mTOR), signaling, AngII increases skeletal muscle proteolysis by forkhead box transcription factors (FOXO), caspase activation and muscle RING-finger protein-1 transcription. Furthermore, AngII infusion in skeletal muscle reduces phospho-Bad (Ser136) expression and induces apoptosis through increased cytochrome c release and DNA fragmentation. Additionally, Renin angiotensin system activation through AT1R and AngII stimulates tumor necrosis factor-α, and interleukin-6 which induces muscle wasting, Last but not least classical RAS pathway, induce oxidative stress, disturb mitochondrial energy metabolism, and muscle satellite cells which all lead to muscle wasting and decrease muscle regeneration. On the contrary, the non-classical RAS pathway functions oppositely to mitigate these mechanisms and protects against muscle wasting. In this review, we summarize the mechanisms of RAS-induced muscle wasting and putative implications for clinical practice. We also emphasize the areas of uncertainties and suggest potential research areas. Graphical abstract Classical and non-classical renin angiotensin systems (RAS) play opposing roles in muscle wasting. Classical RAS system operates through Angiotensin (Ang)I/ACE/AngII)/Angiotensin Type 1 Receptor (AT1R) and induces muscle wasting by mechanisms including inducing anorexia, ubiquitin–proteasome system (UPS), apoptosis, inflammation, oxidative stress, mitochondrial dysfunction, albuminuria, fibrosis (increasing transforming growth factor beta, connective tissue growth factor) and decrease insulin-like growth factor 1 (IGF-1) signaling, vitamin D and satellite cell function. Non-classical RAS system operates through Angiotensin1/ACE2/Ang (1–7)/Mas Receptor and have opposite actions to classical RAS system and protects against muscle wasting.

show abstract

Effects of aerobic exercise training on ACE and ADRB2 gene expression, plasma angiotensin II level, and flow-mediated dilation: a study on obese postmenopausal women with prehypertension

Abstract: Ten weeks of MIET modulates ACE and ADRB2 gene expression, decreases Ang II plasma levels, and improves endothelial function in obese PMW, and these alterations are associated with reduction in BP.

Cited by 32 publications

References 50 publications

Assessment of Electrocardiogram Indices in Postmenopausal Women: Effects of Aerobic Exercise and Detraining

Assessment of Electrocardiogram Indices in Postmenopausal Women: Effects of Aerobic Exercise and Detraining

Exercise and the Endothelium

Renin angiotensin system-induced muscle wasting: putative mechanisms and implications for clinicians

Contact Info

Product

Resources

About