Effects of Aerobic Exercise on Metabolic Syndrome Improvement in Response to Weight Reduction

Okura, Tomohiro; Nakata, Yoshio; Ohkawara, Kazunori; Numao, Shigeharu; Katayama, Yasutomi; Matsuo, Tomoaki; Tanaka, Kiyoji

doi:10.1038/oby.2007.294

Cited by 65 publications

(50 citation statements)

References 25 publications

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“…It is well known that body weight loss through a direct (supervised) lifestyle intervention (LSI) improves metabolic disorders related to obesity. 9,10 However, it is not known whether an indirect LSI through one family member can affect weight loss and the MetS traits of other, untreated family members. Recently, Christakis and Fowler 11 indicated that obesity can spread in social networks, such as friends, siblings and spouses.…”

Section: Introductionmentioning

confidence: 99%

Indirect lifestyle intervention through wives improves metabolic syndrome components in men

Matsuo

Kim

Murotake³

et al. 2009

Int J Obes

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Objectives: It is well known that body weight loss through a direct (supervised) lifestyle intervention (LSI) improves obesityrelated metabolic disorders. The purpose of this study was to investigate the effects of an indirect LSI on weight loss and metabolic syndrome (MetS) in spouses of LSI participants. Methods: A total of 104 men (abdominal circumference X85 cm; age, 52.1 ± 9.3 years) were assigned to one of three groups: no intervention (NI, n ¼ 34), direct intervention (DI, n ¼ 34) or indirect intervention (II, n ¼ 36), the last of which consisted of subjects who did not participate in the direct LSI but whose wives did. Body weight and MetS components were measured before and after a 14-week intervention. Daily energy intake and activity-related energy expenditure were assessed before and during the intervention. The LSI program was mainly consisted of dietary modifications with a physical activity program. Results: No differences were observed across the three groups in any of the measures at baseline. Significant differences were observed among the groups in weight loss (NI, À0.7 ± 1.4; DI, À6.2 ± 3.3 and II, À4.4 ± 3.7 kg) during the intervention. Along with the body weight reductions, significant improvements were observed in most of MetS components within the DI and II groups. When analyzing the spouse pairs in group II, significant correlations were observed in weight loss (r ¼ 0.57) and decreased total energy intake (r ¼ 0.54) between wives and husbands. Conclusions: Indirect LSI in abdominally obese men whose wives were undergoing LSI led to loss of weight and a decreased incidence of MetS, suggesting that indirect LSI may be an effective program for eliciting beneficial change in health status. one spouse has a significant impact on weight loss in the untreated spouse. They clearly showed 'a ripple effect' on weight loss through spouses. However, the studies did not include examinations of MetS components, which can be greatly affected by changes in body adiposity. To the best of our knowledge, the study by Sexton et al. 17 is the only one to show that a health behavior intervention for one spouse has a ripple effect on cardiovascular risk factors in the other, untreated spouse. Although the study focused on three cardiovascular risk factors (blood pressure, cigarette smoking and serum cholesterol) it did not examine subjects' weight loss and MetS components. Thus, none of the earlier studies focused on the effects of an indirect LSI on weight loss and improved MetS components in the untreated spouse. Therefore, in this study, we examined the effects on weight loss and MetS components in abdominally obese Japanese men of an indirect LSI through their wives. The primary hypothesis of our study was that the indirect LSI through wives would affect weight loss and improve the MetS components of the husbands who did not receive the direct LSI. We also had a secondary hypothesis that the weight loss and lifestyle changes of wives would correlate with those of their husbands.

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Section: Introductionmentioning

confidence: 99%

Indirect lifestyle intervention through wives improves metabolic syndrome components in men

Matsuo

Kim

Murotake³

et al. 2009

Int J Obes

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“…Following the 3-month intervention period, participants showed a moderate weight loss of 8% -13% and improvement in MS factors. Complimenting this work, another study from our laboratory showed that when Japanese women participated in a diet-only or diet plus exercise intervention, the adjusted odds ratio was 1.00 or 3.68 for body weight loss (95%CI, 1.02-17.6) (P = 0.04), respectively 13) . These studies demonstrate that, for obese Japanese adults with MS prevalence, aerobic exercise or physical activity plus diet intervention is more effective than diet alone at reducing body weight and MS associated factors.…”

Section: Exercise and Metabolic Syndromementioning

confidence: 86%

“…Based on a series of weight loss studies conducted in our laboratory 11,13,[43][44][45] , Sasai et al (2008) 44) found a proportionally greater loss in VF following exercise alone when compared to diet alone. More recently, we reported that physical activity (PA) intensities modulate the exercise-induced reduction in intra-abdominal fat 45) .…”

Section: Exercise-and/or Diet-induced Weight Lossmentioning

confidence: 99%

“…With this in mind, over the past two decades our research group at the Faculty of Health and Sport Sciences, University of Tsukuba, has continuously implemented fieldbased intervention studies to explore the health benefits of exercise-and/or diet-induced weight loss on a broad range of outcomes. These studies have demonstrated apparent improvements in the majority of outcomes we have measured [7][8][9][10][11][12][13] . One outcome from our work has been the design of the health status concept of "vital age", an individualized measure that accounts for physical fitness and the presence and/or risk of disease, and which may vary from actual chronological age.…”

Section: Introductionmentioning

confidence: 99%

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Exercise, diet, and weight loss

Tanaka¹,

Shigematsu²,

Henwood³

et al. 2012

JPFSM

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Japan is one of the most rapidly aging countries in the world. "Healthy Japan 21" is a Japanese government initiative promoting lifestyle-related disease prevention, health promotion, and successful aging. Increasing physical activity participation among older Japanese, the least physically active of any age group, is especially important for preventing frailty and chronic disease, and the associated health care expenditure. Informed by the research we have to date, the following evidence-based conclusions can be drawn relative to exercise and physical activity for the obese population. A combination of aerobic exercise, resistance exercise and physical activities, in addition to proper diet (mostly caloric restriction: 1200 kcal for women and 1680 kcal for men for a certain period of time), is more effective than either form of intervention alone for reducing body weight, visceral fat, blood pressure, and many other negative health-related variables. Exercise habituation in conjunction with proper diet is also most effective for improving vital age. Incorporating and adhering to these lifestyle factors, coupled with adherence to other known health modifiers (reduced stress, improved sleep, etc) will help reduce individual and population obesity and improve national health.

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“…The main effect of exercise on insulin resistance is the increased expression of intracellular insulin signaling, particularly in GLUT4 skeletal muscle (TeranGarcia et al, 2005). The uptake by skeletal muscle represents the largest component of glucose disposal (Okura et al, 2007). Most of the uptake of glucose is used in the synthesis of glycogen.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet

Motta¹,

Mandarim-de-Lacerda²

2012

Int. J. Morphol.

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SUMMARY: C57BL/6 mice develop signals and symptoms comparable at least in part with the metabolic syndrome in humans. This study aimed to evaluate the beneficial effects of exercise training upon skeletal microcirculation in these mice. Animals were fed one of two diets during an eight week period: standard chow (SC) or very high-fat (HF). Afterwards, the exercise training protocol (treadmill) was established and mice divided into SC and HF sedentary (SC-Sed, HF-Sed) or exercised groups (SC-Ex, HF-Ex), respectively. HF/HF-Sed mice had the greatest body mass (plus 65% than SC-Sed; P<0.0001), and exercise reduced it by 23% (P<0.0001). The plasma insulin was higher in the HF-Sed than in the matched -Ex (P<0.001). The ratio between capillaries/myocytes in HF-Ex group increased by 64% than in HF-Sed group (P<0.001) and increased by 80% in SC-Ex group than in SC-Sed group (P<0.001). In conclusion, exercise improved the lipid profile by reducing body mass gain, insulin resistance, ameliorating the skeletal muscle microcirculation.

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Effects of Aerobic Exercise on Metabolic Syndrome Improvement in Response to Weight Reduction

Cited by 65 publications

References 25 publications

Indirect lifestyle intervention through wives improves metabolic syndrome components in men

Indirect lifestyle intervention through wives improves metabolic syndrome components in men

Exercise, diet, and weight loss

Beneficial Effects of Exercise Training (Treadmill) on Body Mass and Skeletal Muscle Capillaries/Myocyte Ratio in C57BL/6 Mice Fed High-Fat Diet

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