Effects of aerobic exercise on histopathology and toxicology of ZnO and nano ZnO in male rats

Farzanegi, Parvin; Abbaszadeh, Hajar; Daloii, Asieh Abbassi; Kazemi, Mozhgan; Sabbaghian, Masoumeh; Shoeibi, Afsaneh; Nabipour, Roya; Abuhosseini, Zohreh; Azarbayjani, Mohammad Ali

doi:10.1080/02772248.2018.1430233

Cited by 7 publications

(5 citation statements)

References 34 publications

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“…It has been also shown that physical exercise ameliorates hepatic inflammation through down‐regulation of the pro‐inflammatory mediators. More recently, we have shown that aerobic exercise enhances mean level of anti‐inflammatory IL‐10, but decreases TNF‐α in rats (Farzanegi1 et al., 2018). Kawanishi, Yano, Yokogawa, and Suzuki (2010) reported that chronic exercise down‐regulates the expression of hepatic TNF‐α mRNA in rats fed with a high fat diet.…”

Section: Effect Of Exercise Training On Oxidative Stress and Inflamma...mentioning

confidence: 93%

Mechanisms of beneficial effects of exercise training on non‐alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation

Farzanegi

Dâna

Ebrahimpoor

et al. 2019

European Journal of Sport Science

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270

165

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Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder which is associated with accumulation of fats in the liver. It causes a wide variety of pathological effects such as nonalcoholic steatohepatitis (NASH) and cirrhosis, insulin resistance, obesity, hypertension, dyslipidaemia, diabetes and cardiovascular disease. The molecular mechanisms that cause the initiation and progression of NAFLD are not fully understood. Oxidative stress (OS) induced by reactive oxygen species (ROS) and inflammation are likely a significant mechanism which can lead to hepatic cell death and tissue injury. Mitochondrial abnormalities, down-regulation of several antioxidant enzymes, glutathione (GSH) depletion and decreased activity of GSHdependent antioxidants, accumulation of leukocytes and hepatic inflammation are the major sources of ROS overproduction in NAFLD. Excessive production of ROS suppresses the capacity of other antioxidant defence systems in NAFLD and causes further oxidative damage. Regular exercise can be considered as an effective strategy for treatment of NAFLD. It improves NAFLD by reducing intrahepatic fat content, increasing β-oxidation of fatty acids, inducing hepatoprotective autophagy, overexpressing peroxisome proliferator-activated receptor-γ (PPAR-γ), as well as attenuating hepatocyte apoptosis and increasing insulin sensitivity. Exercise training also suppresses ROS overproduction and OS in NAFLD via up-regulation of several antioxidant enzymes and anti-inflammatory mediators. Therefore, an understanding of these molecules and signalling pathways gives us valuable information about NAFLD progression and a method for developing a suitable clinical treatment. This review aimed to evaluate sources of ROS and OS in NAFLD and the molecular mechanisms involved in the beneficial effects of exercises on NAFLD.

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Section: Effect Of Exercise Training On Oxidative Stress and Inflamma...mentioning

confidence: 93%

Mechanisms of beneficial effects of exercise training on non‐alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation

Farzanegi

Dâna

Ebrahimpoor

et al. 2019

European Journal of Sport Science

Self Cite

270

165

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“…In this context, exercise can be useful, as it was shown to suppress OS and ROS overproduction via up-regulation of several antioxidant enzymes and anti-inflammatory mediators [ 159 ]. Several experimental studies reported that exercise can decrease ROS production and pro-inflammatory cytokines, including TNF-α and IL-1β, through the antioxidant activity improvement and acting on NF-κB pathway [ 159 , 164 , 165 , 166 ]. Further studies are necessary to confirm these results and drive definitive conclusions about the mechanisms by which exercise can attenuate hepatic oxidative damage in NAFLD and improve hepatic status, especially in the pediatric field.…”

Section: The Effects Of Physical Exercise On Nafldmentioning

confidence: 99%

Benefits of Physical Exercise as Approach to Prevention and Reversion of Non-Alcoholic Fatty Liver Disease in Children and Adolescents with Obesity

et al. 2022

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Non-alcoholic fatty liver disease (NAFLD) is an important health concern during childhood; indeed, it is the most frequent cause of chronic liver diseases in obese children. No valid pharmacological therapies for children affected by this condition are available, and the recommended treatment is lifestyle modification, usually including nutrition and exercise interventions. In this narrative review, we summarized up-to-date information on the benefits of physical exercise on NAFLD in children and adolescents with obesity. The role of exercise as non-pharmacological treatment was emphasized in order to provide recent advances on this topic for clinicians not deeply involved in the field. Several studies on obese children and adults confirm the positive role of physical activity (PA) in the treatment of NAFLD, but to date, there are no pediatric randomized clinical trials on exercise versus usual care. Among the pathogenic mechanisms involved in the PA effects on NAFLD, the main players seem to be insulin resistance and related inflammation, oxidative stress, and gut dysbiosis, but further evaluations are necessary to deeply understand whether these factors are correlated and how they synergistically act. Thus, a deeper research on this theme is needed, and it would be extremely interesting.

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“…Ozone was injected into the knee through the tibiofemoral joint line at concentration of 20 μg/ml, once weekly for three weeks starting at 21 days after the modeling. The rats were familiarized with treadmill running for one week (three times per week, with VO 2 max of 60-70%, speed of 16 m/min, and zero inclination for 10 min/day) (15). The compared to MSC therapy and exercise training (P<0.01).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of ALK5 and MMP13 Expression in the Cartilage Tissue of Rats with Osteoarthritis Rats and Effects of Exercise Training, Ozone and Mesenchymal Stem Cell Therapies on Expression of these Genes

2020

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Background and objectives: Matrix metalloproteinase-13 (MMP-13) and activin receptor-like kinase 5 (ALK5) are considered as important factors contributing to knee osteoarthritis (OA) pathogenesis. Here, we compared therapeutic effects of mesenchymal stem cells (MSCs), ozone and exercise training alone and combined on expression of MMP-13 and ALK5 in rats with knee OA. Methods: Knee OA was induced by a surgical method. Rats with OA were then randomly divided into several groups, including model, MSCs, ozone, exercise, MSCs + ozone, MSCs + exercise, ozone + exercise and MSCs + ozone + exercise groups. Expression of MMP-13 and ALK5 genes was evaluated using RT-PCR. Data were analyzed using SPSS software at significance of 0.05. Results: Expression of MMP-13 and ALK5 differed significantly between the study groups (P<0.0001). Knee OA was significantly associated with overexpression of MMP-13 and ALK5 in the cartilage tissue of rats with knee OA. Combined therapy with MSCs, ozone and exercise significantly decreased the expression of MMP-13 and ALK5 in the cartilage of rats with OA (P<0.001). Although MSCs, ozone and exercise training were effective to mitigate expression of MMP-13 and ALK5 genes, ozone therapy was more effective compared to the other two therapies. Conclusion: Although ozone, MSCs and exercise training alone could decrease the expression of MMP-13 and ALK5 genes, combined therapy with MSC, ozone and exercise is more effective.

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Effects of aerobic exercise on histopathology and toxicology of ZnO and nano ZnO in male rats

Cited by 7 publications

References 34 publications

Mechanisms of beneficial effects of exercise training on non‐alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation

Mechanisms of beneficial effects of exercise training on non‐alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation

Benefits of Physical Exercise as Approach to Prevention and Reversion of Non-Alcoholic Fatty Liver Disease in Children and Adolescents with Obesity

Evaluation of ALK5 and MMP13 Expression in the Cartilage Tissue of Rats with Osteoarthritis Rats and Effects of Exercise Training, Ozone and Mesenchymal Stem Cell Therapies on Expression of these Genes

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