Mechanisms of beneficial effects of exercise training on non‐alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation

Farzanegi, Parvin; Dâna, Aykutlu; Ebrahimpoor, Zeynab; Asadi, Mahdieh; Azarbayjani, Mohammad Ali

doi:10.1080/17461391.2019.1571114

Cited by 272 publications

(209 citation statements)

References 81 publications

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“…This correlation suggests a relation between incidence of CVD, ALD, and NAFLD. Reversal of ALD and NAFLD at the earlier stage can be achieved by lifestyle changes, such as abstinence, losing weight, and exercise [6,8,19].…”

Section: Effect Of Nafld/ald On Dmmentioning

confidence: 99%

“…Moreover, HCC increases by means of inflammatory reactions [9]. Oxidative stress (OS) induced by ROS and inflammation play an important function, leading to liver cell death and damage of tissue [19,22].…”

Section: Effect Of Nafld/ald On Dmmentioning

confidence: 99%

“…Either excess generation of peroxisome proliferatoractivated receptor-γ (PPAR-γ) or underexpression of hepatocyte apoptosis participates in increasing the sensitivity of insulin [19], which could be achieved by regular improvement of NAFLD via reduced content of lipids in the liver and increased aliphatic acid β-oxidation [19,25]. Physical exercise to lose weight and obtain good control on blood glucose could improve the levels of some antioxidant enzymes and mediators of anti-inflammation.…”

Section: Effect Of Nafld/ald On Dmmentioning

confidence: 99%

“…Physical exercise to lose weight and obtain good control on blood glucose could improve the levels of some antioxidant enzymes and mediators of anti-inflammation. These interventions further inhibit the overexpression of ROS and OS among NAFLD patients [19] and achieve maximum control of disease progression. Treatment for regulating intestinal flora decreases the susceptibility of NAFLD and chronic vascular complications of DM [11].…”

Section: Effect Of Nafld/ald On Dmmentioning

confidence: 99%

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Management of Diabetes Mellitus in Patients with Chronic Liver Diseases

Zhao

Xing

Wang

et al. 2019

Journal of Diabetes Research

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Diabetes mellitus (DM) is a common chronic disease affecting humans globally. During the last few years, the incidence of diabetes has increased and has received more attention. In addition to growing DM populations, DM complications are involving injuries to more organs, such as the heart and cerebral vessel damage. DM complications can reduce quality of life and shorten life spans and eventually also impede social and economic development. Therefore, effective measures to curb the occurrence and development of diabetes assist in improving patients’ quality of life, delay the progression of DM in the population, and ease a social burden. The liver is regarded as an important link in the management and control of DM, including the alleviation of glucose metabolism and lipid metabolism and others via glucose storage and endogenous glucose generation from glycogen stored in the liver. Liver cirrhosis is a very common chronic disease, which often lowers the quality of life and decreases life expectancy. According to a growing body of research, diabetes shows a close correlation with hepatitis, liver cirrhosis, and liver cancer. Moreover, coexistence of liver complications would accelerate the deterioration of patients with diabetes. Liver cirrhosis and diabetes influence each other. Thus, in addition to pharmacological treatments and lifestyle interventions, effective control of cirrhosis might assist in a better management of diabetes. When it comes to different etiologies of liver cirrhosis, different therapeutic methods, such as antiviral treatment, may be more effective. Effective control of cirrhosis might be a strategy for better management of diabetes.

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Section: Effect Of Nafld/ald On Dmmentioning

confidence: 99%

Section: Effect Of Nafld/ald On Dmmentioning

confidence: 99%

Section: Effect Of Nafld/ald On Dmmentioning

confidence: 99%

Section: Effect Of Nafld/ald On Dmmentioning

confidence: 99%

See 2 more Smart Citations

Management of Diabetes Mellitus in Patients with Chronic Liver Diseases

Zhao

Xing

Wang

et al. 2019

Journal of Diabetes Research

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“…e term "oxidative stress" implies a physiological imbalance in the ROS creation and scavenging. Inflammation, which is triggered by oxidative stress, is associated with many diseases, such as oral ulcers [5], neurodegenerative diseases [6], tumour [7,8], cardiovascular disease [9,10], type 2 diabetes [11], nonalcoholic fatty liver disease [12], and Parkinson's disease [13]. Since it has been recognized that antioxidants can alleviate inflammatory reactions, some antioxidants have been studied and proposed for therapeutic use based on their therapeutic effects [14], e.g., vitamin C, coenzyme Q10, and some polyphenols that are isolated from herbs [15].…”

Section: Introductionmentioning

confidence: 99%

Zhibaidihuang Decoction Ameliorates Cell Oxidative Stress by Regulating the Keap1‐Nrf2‐ARE Signalling Pathway

Ding

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Zhibaidihuang decoction (ZBDHD) is a Chinese herbal formula, which is used in Chinese traditional medicine to treat symptoms of Yinxuhuowang (Yin deficiency and high fire) syndrome. This study elucidates the mechanism of ZBDHD on oral ulcers, one Yinxuhuowang syndrome. Simultaneously, some ingredients in ZBDHD were found and identified by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). A Ganjiangfuzirougui decoction- (GJD-) induced Yinxuhuowang syndrome SD rat model was used to demonstrate the efficiency of ZBDHD treatment. The oral mucosa of rat in the GJD group, stained with hematoxylin and eosin (H&E), showed epidermal shedding and inflammatory cell infiltration. And an alleviation efficiency of ZBDHD in GJD-induced pathological changes in the oral mucosa could be obtained. ZBDHD treatment restored the GJD-induced imbalance of metabolites, which were choline, glycocholic acid, and palmitoyl-L-carnitine (PALC). GJD stimulated the expression of NF-κB. And the overexpressed of NF-κB in mucosa of rat in the GJD group could be inhibited by ZBDHD treatment. Simultaneously, the optimal efficiency of ZBDHD treatment on the cellular ATP content, oxygen consumption rate (OCR), and superoxide dismutase (SOD) concentration was evaluated, in vitro assay. Compared to the control cells, the ATP content, OCR, and SOD activity in the ZBDHD-treated cells were significantly higher. For the mechanisms study, seven cytokines were screened with a Dual-Luciferase Reporter gene assay. In the ARE assay, the luciferase signal was stimulated significantly by ZBDHD. In cells, the transcription of nrf2, maf, and keap1, which were related to the ARE pathway, was elevated by ZBDHD treatment. Our study demonstrated that high-dose GJD could lead to Yinxuhuowang syndrome, such as oral ulcers, and the imbalance in serum metabolites. And ZBDHD can improve oral cell inflammation and the imbalance of metabolism by inhibiting NF-κB and enhancing the activity of the ARE signalling pathway to ameliorate oxidative stress in the cell. This study provides a theoretical basis for the clinical application of ZBDHD.

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Young Adult Physical Activity Trajectories and Midlife Nonalcoholic Fatty Liver Disease

de Brito,

McDonough,

Mathew

et al. 2023

JAMA Netw Open

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ImportancePhysical activity (PA) is recommended for preventing and treating nonalcoholic fatty liver disease (NAFLD). Yet, how long-term patterns of intensity-based physical activity, including moderate-intensity PA (MPA) and vigorous-intensity PA (VPA), might affect the prevalence of NAFLD in middle age remains unclear.ObjectiveTo identify distinct intensity-based PA trajectories from young to middle adulthood and examine the associations between PA trajectories and NAFLD prevalence in midlife.Design, Setting, and ParticipantsThis population-based cohort of 2833 participants used the Coronary Artery Risk Development in Young Adults study data. The setting included field clinics in Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; and Oakland, California. Data analysis was completed in March 2023.ExposuresPA was self-reported at 8 examinations over 25 years (1985-1986 to 2010-2011) and separately scored for MPA and VPA.Main Outcomes and MeasuresNAFLD was defined as liver attenuation values less than 51 Hounsfield units after exclusion of other causes of liver fat, measured using computed tomography in year 25 (2010-2011).ResultsAmong a total of 2833 participants included in the sample, 1379 (48.7%) self-identified as Black, 1454 (51.3%) as White, 1206 (42.6%) as male, and 1627 (57.4%) as female from baseline (1985-1986) (mean [SD] age, 25.0 [3.6] years) to year 25 (2010-2011) (mean [SD] age, 50.1 [3.6] years). Three MPA trajectories were identified: very low stable (1514 participants [53.4%]), low increasing (1096 [38.7%]), and moderate increasing (223 [7.9%]); and 3 VPA trajectories: low stable (1649 [58.2%]), moderate decreasing (1015 [35.8%]), and high decreasing (169 [6.0%]). After adjustment for covariates (sex, age, race, study center, education, smoking status, and alcohol consumption), participants in the moderate decreasing (risk ratio [RR], 0.74; 95% CI, 0.54-0.85) and the high decreasing (RR, 0.59; 95% CI, 0.44-0.80) VPA trajectories had a lower risk of NAFLD in middle age, relative to participants in the low stable VPA trajectory. Adjustments for baseline body mass index and waist circumference attenuated these estimates, but the results remained statistically significant. The adjusted RRs across the MPA trajectories were close to null and not statistically significant.Conclusions and RelevanceThis cohort study of Black and White participants found a reduced risk of NAFLD in middle age for individuals with higher levels of VPA throughout young to middle adulthood compared with those with lower VPA levels. These results suggest the need for promoting sustainable and equitable prevention programs focused on VPA over the life course to aid in lowering NAFLD risk.

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Mechanisms of beneficial effects of exercise training on non‐alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation

Cited by 272 publications

References 81 publications

Management of Diabetes Mellitus in Patients with Chronic Liver Diseases

Management of Diabetes Mellitus in Patients with Chronic Liver Diseases

Zhibaidihuang Decoction Ameliorates Cell Oxidative Stress by Regulating the Keap1‐Nrf2‐ARE Signalling Pathway

Young Adult Physical Activity Trajectories and Midlife Nonalcoholic Fatty Liver Disease

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