Effects of Adrenal and Gonadal Products on the Weight and Radioiodine Uptake of the Thyroid Gland in the Rat*†

The Influence of Acth, Cortisone, and Hydrocortisone on the Distribution and Peripheral Metabolism of Thyroxine 1

“…Despite the diminution in SPI, 13177 the rate of degradation of thyroxine during the administration of ACTH was as great as it had been during the control period. Others have reported profound diminutions in the SPI of euthyroid patients receiving cortisone for no longer than the period of treatment employed in the present study (2,18). Furthermore, no abnormality in the peripheral degradation of thyroxine could be demonstrated in a patient with longstanding active Cushing's syndrome.7 These observations indicate that failure of the SPI to decline during the present study did not result from therapy of insufficient duration.…”

“…Renewed interest in thyroid-adrenal interrelations has followed recent demonstrations that alterations in the availability of certain adrenocortical steroids may induce pronounced changes in the metabolism of iodine (1)(2)(3)(4)(5)(6)(7)(8)(9). These changes have been variously ascribed to effects of cortical steroids on the pituitary gland (1), the thyroid (10,11) and the kidney (12,13).…”

STUDIES ON THE THYROID UPTAKE OF I<SUP>131</SUP> I. EFFECT OF PITUITARY HORMONES

“…In clinical experiences, Hill et al(1950)by the decrease of I131 accumulation in the thyroid, Hardy et al(1950)by the decrease of PBI, and Wolfson et al(1950)by the changes in thyroid uptake of I131, PBI, BMR and cholesterol in blood, all claimed that the thyroid function was depressed by ACTH. In experiment with rats, Money et al(1950Money et al( , 1951reported that the administration of ACTH produced signifiant decrease in I131 uptake by the thyroid. Soffer et al (1951), observing decrease of both thyroxine and nonthyroxine fractions of thyroid I131 in normal and adrenalectomized rats after the administration of ACTH, stated that both the I131 uptake and hormone synthesis are inhibited by ACTH, and that the inhibition would not be through arresting TSH secretion in the anterior pituitary but through the direct action upon the thyroid.…”

EFFECT OF CORTISONE ON THE ACTION OF THYROXINE AND TRIIODOTHYRONINE IN HYPOPHYSECTOMIZED RATS1,2

“…It was increased to high levels in the triiodothyronine-treated animals. In the cortisone-pretreated rats the basal oxygen consumption was slightly increased, but 2 Significance level of change in oxygen consumption as affected by administration of thyroxine or triiodothyronine. 8 Significance level of cortisone-induced modification of response to thyroxine or triiodothyronine.…”

“…Suggestions have included a depressive action on the pituitary gland (1), on the thyroid (2,3,4), an increased renal disposal of iodide (5), and a direct antagonistic effect on the circulating hormone (6,7).…”