Effects of Acute Thermal Stress on the Immune System of the Northern Bobwhite (Colinus virginianus)

Dabbert, C. Brad; Lochmiller, Robert L.; Teeter, R. G.

doi:10.2307/4089069

Cited by 42 publications

(28 citation statements)

References 32 publications

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“…However, for some fish and amphibians, immune responses can be stimulated or at least positively correlated with increases in temperatures, 117,124 including lysozyme and immunoglobulin M levels 124–126 . Effects of temperature change on endotherms are generally weaker, 127–129 although results are contingent on what is measured and the magnitude of temperature perturbation. For instance, cytokine‐stimulated T‐cell proliferative responsiveness was sensitive to temperature in some rodents, 130 and heat stress (up to 40° C) reduced multiple innate and adaptive immune functions in chickens 131,132 and egg‐laying hens 133 .…”

Section: Temperature Changementioning

confidence: 99%

The effects of anthropogenic global changes on immune functions and disease resistance

Martin¹,

Hopkins²,

Mydlarz³

et al. 2010

Annals of the New York Academy of Sciences

208

187

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Humans are changing the environmental conditions of our planet, and animal immune functions are being affected by these modifications. For instance, a diversity of chemical contaminants is entering ecosystems and modifying immune functions directly or indirectly through altered host-parasite interactions. Also, global temperature changes have caused outbreaks of disease that have decimated and even extirpated some host species, outcomes partially driven via immune alterations. Finally, some invasive species are immunologically distinct or impose stress on native species, factors that may facilitate the establishment of nonnative hosts as well as parasite transmission to native species. Here, we summarize the known and likely effects of pollutants, nonnative species introductions, and increases in ambient temperature on host immune functions and infections. We then identify future directions for research given our sparse knowledge of immune variation in natural populations. In sum, we advocate integrative, multidisciplinary work at diverse spatial and temporal scales to assess and prevent anthropogenic global changes from further compromising animal immune functions.

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Section: Temperature Changementioning

confidence: 99%

The effects of anthropogenic global changes on immune functions and disease resistance

Martin¹,

Hopkins²,

Mydlarz³

et al. 2010

Annals of the New York Academy of Sciences

208

187

View full text Add to dashboard Cite

show abstract

“…To our knowledge, no studies reporting a decrease (Bartlett and Smith, 2003;Khajavi et al, 2003Khajavi et al, , 2003Mashaly et al, 2004;Niu et al, 2009;Jin et al, 2011) or the lack of difference in the level of the immune response following exposure to high ambient temperatures (Dabbert et al, 1997;Mashaly et al, 2004;Sutherland et al, 2006;Pamok et al, 2009;Star et al, 2009) associated this response with the capacity to dissipate excess heat. Instead, these results have been discussed primarily in the context of physiological responses to environmental stress (e.g.…”

Section: Lymph Node Mass (G)mentioning

confidence: 99%

Heat dissipation does not suppress an immune response in laboratory mice divergently selected for basal metabolic rate (BMR)

Książek

Konarzewski

2016

Journal of Experimental Biology

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The capacity for heat dissipation is considered to be one of the most important constraints on rates of energy expenditure in mammals. To date, the significance of this constraint has been tested exclusively under peak metabolic demands, such as during lactation. Here, we used a different set of metabolic stressors, which do not induce maximum energy expenditures and yet are likely to expose the potential constraining effect of heat dissipation. We compared the physiological responses of mice divergently selected for high (H-BMR) and low basal metabolic rate (L-BMR) to simultaneous exposure to the keyhole limpet haemocyanin (KLH) antigen and high ambient temperature (T a ). At 34°C (and at 23°C, used as a control), KLH challenge resulted in a transient increase in core body temperature (T b ) in mice of both line types (by approximately 0.4°C). Warm exposure did not produce line-type-dependent differences in T b (which was consistently higher by ca. 0.6°C in H-BMR mice across both T a values), nor did it result in the suppression of antibody synthesis. These findings were also supported by the lack of between-line-type differences in the mass of the thymus, spleen or lymph nodes. Warm exposure induced the downsizing of heatgenerating internal organs (small intestine, liver and kidneys) and an increase in intrascapular brown adipose tissue mass. However, these changes were similar in scope in both line types. Mounting a humoral immune response in selected mice was therefore not affected by ambient temperature. Thus, a combined metabolic challenge of high T a and an immune response did not appreciably compromise the capacity to dissipate heat, even in the H-BMR mice.

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“…Differential WBC counts have been used to assess the health status of wild birds (e.g., Driver 1981;Hõrak et al 1998;Sergent et al 2004). In particular, the ratio of heterophils to lymphocytes (H/L ratio) has been demonstrated to be a reliable indicator of stress (Gross and Siegel 1983;Maxwell 1993), as the H/L ratio has been shown to increase in response to stressors such as food deprivation (Gross and Siegel 1986), thermal stress (Dabbert et al 1997), and injury (Vleck 2001). Heterophils are involved in innate immune function providing non-specific defense primarily against bacteria while lymphocytes are involved in acquired immune function against specific pathogens (Maxwell 1993).…”

Section: Introductionmentioning

confidence: 99%

Arrival timing and hematological parameters in Gray Catbirds (Dumetella carolinensis)

2010

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Early arrival at the breeding grounds for migratory birds is associated with greater reproductive success. According to the condition-dependent arrival hypothesis, only those individuals in superior physiological condition are able to bear the costs (e.g., poor environmental conditions, limited food availability) of early arrival. Condition has usually been measured in terms of energy reserves or mass but other physiological measures of condition such as hematocrit and immune function have been gaining attention. We examined several measures of condition and their association with date of first capture in Gray Catbirds (Dumetella carolinensis) arriving at breeding grounds in northeastern Pennsylvania. Earlier arrivals had higher hematocrit and H/L ratios and lower lymphocyte counts. Arrival date was also negatively associated with fat score. Fat score was positively related to hematocrit, total number of leukocytes, and number of lymphocytes, but the other hematological parameters were not associated with traditional measures of condition (keel score, fat score, or a body condition index). Our results provide some support for the condition-dependent arrival hypothesis and suggest that there may be immunological differences between early-and late-arriving birds.

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Effects of Acute Thermal Stress on the Immune System of the Northern Bobwhite (Colinus virginianus)

Cited by 42 publications

References 32 publications

The effects of anthropogenic global changes on immune functions and disease resistance

The effects of anthropogenic global changes on immune functions and disease resistance

Heat dissipation does not suppress an immune response in laboratory mice divergently selected for basal metabolic rate (BMR)

Arrival timing and hematological parameters in Gray Catbirds (Dumetella carolinensis)

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