Effects of acute systemic and intra-cerebral stimulation of cannabinoid receptors on sensorimotor gating, locomotion and spatial memory in rats

Wegener, Nico; Kuhnert, Sybille; Thüns, Annika; Roese, Rasmus; Koch, Michael

doi:10.1007/s00213-008-1148-1

Cited by 49 publications

(41 citation statements)

References 72 publications

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“…Moreover, comparable with the effect of systemic CORT administration, intrahippocampal infusions of the full CB agonist WIN55,212-2 impaired the retrieval of contextual but not auditory fear memory. This selective impairment of retrieval of contextual fear memory indicates that the WIN55,212-2 administration did not nonspecifically affect the expression of freezing behavior, a finding that is in accordance with other reported evidence that intrahippocampal administration of WIN55,212-2 or other cannabinoid agonists (δ-9-tetrahydrocannabinol or CP 55,940) impairs spatial memory without directly affecting the expression of behaviors that were assessed as an index of memory (43)(44)(45). Moreover, we found that CORT administration, in a dose that impairs memory retrieval, increased hippocampal levels of 2-AG but not AEA or other measured endocannabinoids in the same time course of the retention test.…”

Section: Discussionsupporting

confidence: 90%

Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory

Atsak

Hauer

Campolongo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

117

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There is extensive evidence that glucocorticoid hormones impair the retrieval of memory of emotionally arousing experiences. Although it is known that glucocorticoid effects on memory retrieval impairment depend on rapid interactions with arousalinduced noradrenergic activity, the exact mechanism underlying this presumably nongenomically mediated glucocorticoid action remains to be elucidated. Here, we show that the hippocampal endocannabinoid system, a rapidly activated retrograde messenger system, is involved in mediating glucocorticoid effects on retrieval of contextual fear memory. Systemic administration of corticosterone (0.3-3 mg/kg) to male Sprague-Dawley rats 1 h before retention testing impaired the retrieval of contextual fear memory without impairing the retrieval of auditory fear memory or directly affecting the expression of freezing behavior. Importantly, a blockade of hippocampal CB1 receptors with AM251 prevented the impairing effect of corticosterone on retrieval of contextual fear memory, whereas the same impairing dose of corticosterone increased hippocampal levels of the endocannabinoid 2-arachidonoylglycerol. We also found that antagonism of hippocampal β-adrenoceptor activity with local infusions of propranolol blocked the memory retrieval impairment induced by the CB receptor agonist WIN55,212-2. Thus, these findings strongly suggest that the endocannabinoid system plays an intermediary role in regulating rapid glucocorticoid effects on noradrenergic activity in impairing memory retrieval of emotionally arousing experiences.cannabinoid receptor | norepinephrine | emotional arousal | fear conditioning | posttraumatic stress disorder I t is well-established that glucocorticoid (GC) hormones, released from the adrenal cortex during stressful episodes, can modulate different memory processes (1-4). Although most studies focused on GC effects on the acquisition and consolidation of memory, extensive evidence also indicates that acutely elevated GC levels at the time of retention testing impair the retrieval of memory of spatial and contextual training (5-9). Because a glucocorticoid receptor (GR) agonist infused into the hippocampus before retention induces comparable memory retrieval impairment (10, 11), such findings suggest that GC effects on memory retrieval depend, at least in part, on activation of GRs in the hippocampus. Findings of studies of human subjects are consistent with the findings of animal studies and indicate that exogenous GC administration or exposure to a psychosocial stressor shortly before retention testing impairs retrieval of declarative (mostly episodic) information (7, 12, 13) and reduces hippocampal activity (14). Moreover, previous findings indicate that emotionally arousing information is especially sensitive to the retrieval-impairing effects of GCs (8) and that emotional arousal during the test situation enables GC effects on memory retrieval (15). Findings of recent clinical studies suggest that the administration of stress doses of GCs may have therapeutic v...

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Section: Discussionsupporting

confidence: 90%

Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory

Atsak

Hauer

Campolongo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

117

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“…Albeit, it is not possible to define whether visual and acoustic alterations induced by JWH-018 and D 9 -THC in mice are an expression of hallucinatory states, our data support the hypothesis that JWH-018 by stimulating CB 1 receptors could impair the sensorimotor gating in mice similar to what was demonstrated for other cannabinoid agonists such as D 9 -THC (Malone and Taylor, 2006;Nagai et al, 2006), CP 55940 (Mansbach et al, 1996;Martin et al, 2003) and WIN 55,212-2 (Schneider and Koch, 2002;Wegener et al, 2008). Further studies will be conducted using the pre-pulse inhibition test, to investigate the potential psychogenic effect of JWH-018.…”

Section: Discussionsupporting

confidence: 85%

JWH-018 impairs sensorimotor functions in mice

et al. 2015

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“…The reported effects of cannabinoid administration on PPI in animals are inconsistent (Bortolato et al 2005;Malone and Taylor 2006;Martin-Iverson and Cornelisse 2005;Martin et al 2003;Nagai et al 2006;Schneider et al 2005;Koch 2003, 2002;Stanley-Cary et al 2002;Wegener et al 2008). In humans, one study found no difference between cannabis users and non-users in an uninstructed PPI task (Quednow et al 2004), while another study by Kedzior and Martin-Iverson (2007) found that chronic cannabis users failed to show significant attentional modulation of PPI, and had reduced PPI relative to controls, but only when they were instructed to sustain attention to the auditory stimuli, not when they were instructed to ignore the stimuli and focus on a visual task.…”

mentioning

confidence: 94%

Alterations to pre-pulse inhibition (PPI) in chronic cannabis users are secondary to sustained attention deficits

Scholes

Martin‐Iverson

2009

Psychopharmacology

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Effects of acute systemic and intra-cerebral stimulation of cannabinoid receptors on sensorimotor gating, locomotion and spatial memory in rats

Cited by 49 publications

References 72 publications

Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory

Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory

JWH-018 impairs sensorimotor functions in mice

Alterations to pre-pulse inhibition (PPI) in chronic cannabis users are secondary to sustained attention deficits

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