Effects of acute starvation on cold-induced thermogenesis in the preweanling rat

Impaired Suppression of Sympathetic Activity during Fasting in the Gold Thioglucose-treated Mouse

“…8 is available from studies of thermogenic responses to cold exposure. Malnourished human infants and acutely starved, preweanling rats fail to increase oxygen consumption normally upon exposure to environmental temperatures of 20°-30°C (29,30). In rats, this metabolic restraint of fasting is eliminated by surgical decerebration, indicating the presence of descending inhibitory input in these fasting animals (31).…”

“…The plastic-coated thermistor was dipped in mineral oil and inserted 2 cm into the (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) Ci/mmol sp act; New England Nuclear, Boston, Mass.) was purified before use by column chromatography with alumina as described below.…”

Changes in Metabolic Rate and Brown Adipose Tissue Composition during Nutritional Rehabilitation of Postnatally Undernourished Rats

“…However, it was noted that, both at the end of the period of undernutrition and for a period during rehabilitation, PU rats showed body temperatures significantly below those of controls. The low rectal temperature of C pups at 21 days is normal for rats of this age maintained at 23 °C [23] and the further hy pothermia of the 21-day-old PU rats may be a simple consequence of inanition, or of the inhibition of thermogenesis during starvation [2], but the 30-day measurements were on pups which had been well fed for over a week. One effect of growth retardation during the suckling period will be to delay develop ment of the rat's ability to thermoregulate [6] and the delayed development, together with the small size and poor insulation of the PU rats, may mean that PU weanlings rely more on heat production than on heat conserva tion as a thermoregulatory strategy.…”

Metabolic and Hormonal Response to Endotoxin Fever in Fed and Starved One-Week Rabbits

“…Other investigators found increased blood glucose and alanine levels in human adults during infection and endotoxaemia [29,30], Since resting blood metabolite levels and the metabolic response to endotoxin of starved and fed baby rabbits did not show major differences, the different thermal re sponse cannot be explained on this basis. It is possible that starvation-induced thermoregu latory changes [3][4][5] are responsible for the phenomenon.…”

“…Well-fed newborn rabbits, kittens and guinea pigs increase their body temperature [1] in response to endotoxin injection, but starved newborn rabbits become hypother mic [2], Nutritional state can influence ther moregulation [3,4] and newborn animals are especially vulnerable in this respect [5][6][7][8], During starvation thermoregulatory control is obviously altered [3][4][5], but peripheral sub strate deficiency or the inability to mobilize energy reserves might also play a role in the hypothermic response to endotoxin. To in vestigate the latter possibility endotoxin was injected in well-fed and starved newborn rab bits and thermal, metabolic and hormonal responses were examined.…”