Effects of acute kidney injury on acute pancreatitis patients’ survival rate in intensive care unit: A retrospective study

Abstract

BACKGROUND Acute kidney injury (AKI) is one of the most common acute pancreatitis (AP)-associated complications that has a significant effect on AP, but the factors affecting the AP patients’ survival rate remains unclear. AIM To assess the influences of AKI on the survival rate in AP patients. METHODS A total of 139 AP patients were included in this retrospective study. Patients were divided into AKI group ( n = 72) and non-AKI group ( n = 67) according to the occurrence of AKI. Data were collected from medical records of hospitalized patients. Then, these data were compared between the two groups and further analysis was performed. RESULTS AKI is more likely to occur in male AP patients ( P = 0.009). AP patients in AKI group exhibited a significantly higher acute physiologic assessment and chronic health evaluation II score, higher Sequential Organ Failure Assessment score, lower Glasgow Coma Scale score, and higher demand for mechanical ventilation, infusion of vasopressors, and renal replacement therapy than AP patients in non-AKI group ( P < 0.01, P < 0.01, P = 0.01, P = 0.001, P < 0.01, P < 0.01, respectively). Significant differences were noted in dose of norepinephrine and adrenaline, duration of mechanical ventilation, maximum and mean values of intra-peritoneal pressure (IPP), maximum and mean values of procalcitonin, maximum and mean serum levels of creatinine, minimum platelet count, and length of hospitalization. Among AP patients with AKI, the survival rate of surgical intensive care unit and in-hospital were only 23% and 21% of the corresponding rates in AP patients without AKI, respectively. The factors that influenced the AP patients’ survival rate included body mass index (BMI), mean values of IPP, minimum platelet count, and hospital day, of which mean values of IPP showed the greatest impact. CONCLUSION AP patients with AKI had a lower survival rate and worse relevant clinical outcomes than AP patients without AKI, which necessitates further attention to AP patients with AKI in surgical intensive care unit.

The outcome of acute pancreatitis patients with acute kidney injury- Single centre study from North India

“…A retrospective study of 139 AP patients found higher acute physiologic assessment and chronic health evaluation II score, higher Sequential Organ Failure Assessment score in patients with AKI. 22 This study also found lower survival rate in AKI patients.…”

Continuous Renal Replacement Therapy With oXiris Filter May Not be an Effective Resolution to Alleviate Cytokine Release Syndrome in Non-AKI Patients With Severe and Critical COVID-19

“…This approach has also been proposed as adjuvant therapy in many diseases, including sepsis (Monard et al, 2019), septic AKI (Turani et al, 2019), septic shock (Schwindenhammer et al, 2019), severe Middle East Respiratory Syndrome (MERS) (Cha et al, 2015), severe acute pancreatitis (SAP) with or without ARDS (Cui et al, 2014;Gao et al, 2018), CRS induced by some immunotherapies (Constantinescu et al, 2020), severe burns (Peng et al, 2005), etc. Yet, a non-selective clearance allows harmful and beneficial substances to be simultaneously removed during CRRT (Shi et al, 2021). Moreover, the potential disadvantages of CRRT, such as technical complications of establishing vascular access, anti-coagulation-related complications, hemodynamic instability, internal environment disturbance, obstacles to the spontaneous recovery of renal function, and huge cost, should not be ignored in clinical practice.…”

A prediction model with measured sentiment scores for the risk of in-hospital mortality in acute pancreatitis: a retrospective cohort study

“…Acute pancreatitis (AP) is an inflammatory disease of the pancreas and is the cause of substantial mortality and morbidity worldwide (1). In the general population, the incidence of AP is 34 per 100,000 people annually and continues to increase (2).…”