Effects of Acute Ingestion of Native Banana Starch on Glycemic Response Evaluated by Continuous Glucose Monitoring in Obese and Lean Subjects

Abstract

An abnormal glycemic profile, including postprandial glycemia and acute glucose spikes, precedes the onset of overt diabetes in obese subjects. Previous studies have shown the beneficial effects of chronic native banana starch (NBS) supplementation. In this study, we examined the effects of acute ingestion of NBS on glycemic profiles by means of continuous glucose monitoring in obese and lean subjects. In a crossover study, obese and lean subjects consumed beverages containing either 38.3 g of NBS or 38.3 g of digestible corn starch (DCS) twice daily during 4 days. On day 5, a 3-h meal tolerance test (MTT) was performed to evaluate glucose and insulin responses. After 1 week of washout period, treatments were inverted. NBS supplementation reduced the 48-h glycemia AUC in lean, obese, and in the combined group of lean and obese subjects in comparison with DCS. Postprandial glucose and insulin responses at MTT were reduced after NBS in comparison with DCS in all groups. However, no changes were observed in glycemic variability (GV) indexes between groups. In conclusion, acute NBS supplementation improved postprandial glucose and insulin responses in obese and lean subjects during 48 h of everyday life and at MTT. Further research to elucidate the mechanism behind these changes is required.

Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study

“…Contrary to our hypothesis, RS did not induce a reduction in the 24 h MBG levels, but it actually enhanced them in comparison with the DMS in the period from days 2 to 4. These findings disagree with a previous study from our team, where 38.3 g of NBS administered during four days reduced the 48 h glycemia AUC in comparison with the same doses of digestible corn starch in lean persons and patients with obesity [13]. The remarkable difference between these studies is that, in the one performed earlier, the two administered treatments were unmatched for digestible starch content and, therefore, the beneficial effect of NBS on MBG was expected owing to the difference in digestion rates between starches.…”

“…Moreover, a single acute administration induced a reduction in glycemic and insulin response in healthy participants [12]. In another study, the administration of 40 g of RS2, distributed into two beverages/day for four days to lean and obese participants, reduced the 48 h glycemia AUC, but there were no modifications in GV indexes [13]. However, we attributed these findings to the lack of altered GV among the studied group.…”

“…It is well known that the digestion rate is the key mechanism for regulating postprandial blood glucose response and depends on the amylolysis caused by the gastrointestinal enzymes. It is worth mentioning that most studies encountering improved glycemic outcomes after RS supplementation have been conducted in experiments where RS replaces DS content [13,23,24] and, in contrast, when RS is added as an extra portion to DS content the results have been mixed [7,25].…”

Beneficial effects of green banana biomass consumption in patients with pre-diabetes and type 2 diabetes: a randomised controlled trial

“…The native banana starch reduced the 48-h glycaemia in lean and obese groups separately as well as in a combined group as compared with digestible maize starch. The native banana starch also reduced the postprandial glucose and insulin responses after a meal tolerance test (36) .…”

Green-banana biomass consumption by diabetic patients improves plasma low-density lipoprotein particle functionality

“…Resistant starch (RS) is a form of starch that resists digestion in the small intestine and is classified as a type of dietary fiber 5 . Unripe (green) banana belongs to a RS2 class, being well known as a food with low glycemic index, non-manufactured, attractive and inexpensive food containing different kinds of fibers, vitamins, minerals and bioactive compounds with high RS content 2 , 3 , 6 – 8 .…”