Effects of acute and chronic dieldrin administration on liver and plasma esterases of the rat

Zemaitis, Michael A.; Oberholser, Karl M.; Greene, Frank E.

doi:10.1016/s0041-008x(76)80005-1

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…It has been shown that one acute dose of dieldrin increases carboxylesterase activity in the rat liver after 48 h, remaining for 120 h in both sexes. In serum, the dieldrin administration decreases the activity in females but causes no change in males (ZEMAITIS 1976).…”

Section: Discussionmentioning

confidence: 95%

“…DDT and PCB have also been shown to affect the implantation of eggs, probably by changing the relations between estrogen and progesteron (LUNi) BmG and KIHLSTROM 1973). Dieldrin changes the cholinesterase activity in female plasma and also the carboxylesterases in both sexes (ZEMAITIS 1976. ) It seems probable that PCB may cause changes in the activity and relative proportion of the different molecular forms of esterases in intact house mice.…”

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confidence: 99%

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Effects of testosterone propionate and polychlorinated biphenyls (PCB) on the activity of nonspecific esterases in the house mouse

Andersson

Tegelström

2009

Hereditas

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NMRl mice were treated with testosterone propionate (TSP) and PCB. The effect on nonspecific esterase activity and the relative activities of the various molecular forms of nonspecific esterases were noted. The activity of most molecular forms is sex specific in serum, liver and kidney. Administration of TSP affects the sex specificity, especially in serum. The kidney is most sensitive to TSP. There is a general difference between liver and kidney in the response to TSP. Administration of PCB causes changes in activity and distribution of different molecular forms. There seems to be no connection between TSP and PCB in their effects on nonspecific esterases.

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Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

Effects of testosterone propionate and polychlorinated biphenyls (PCB) on the activity of nonspecific esterases in the house mouse

Andersson

Tegelström

2009

Hereditas

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Acute toxicity of organophosphorus and organochlorine insecticides in laboratory animals

et al. 1979

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The influence of acute poisoning with Dursban (O.P.I.) and D.D.T. (O.cl.I.) on serum enzymes and histopathological examination of the liver, kidney and testes was investigated in albino rats. Two repeated i.p. injections of Dursban in a dose of half the LD 50 resulted in a significant increase in serum GOT, GPT and alkaline phosphatase activity and a decrease of cholinesterase. In case of DDT, two doses of 150 mg/kg orally resulted in a significant increase in the activity of serum GPT only, while three doses increased serum GOT and GPT. No significant change was observed in serum alkaline phosphatase and cholinesterase activity. Regarding the pathological examination it was found that in animals treated with Dursban there was liver necrosis of mid-zonal type and fatty change at the periphery. In case of DDT the liver cells lost their radial arrangements and showed fatty change. There was cellular infiltration in the centre, mostly mononucleolar cells. In both insecticides there was necrosis of some of the seminiferous tubules of the testes and cloudy swelling of the convoluted tubules of the kidney. Histochemical study of the liver in animals treated with Dursban showed that glycogen was deposited at one side of the cell. However, there was depletion of glycogen around the central vein. In liver treated with DDT there were large globules of fat inside the liver cells, indicating increased fat content compared to control liver, where there were tiny minute droplets of fat.

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Effects of acute and chronic dieldrin administration on liver and plasma esterases of the rat

Cited by 2 publications

References 15 publications

Effects of testosterone propionate and polychlorinated biphenyls (PCB) on the activity of nonspecific esterases in the house mouse

Effects of testosterone propionate and polychlorinated biphenyls (PCB) on the activity of nonspecific esterases in the house mouse

Acute toxicity of organophosphorus and organochlorine insecticides in laboratory animals

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