Effects of acute ammonia toxicity on oxidative stress, DNA damage and apoptosis in digestive gland and gill of Asian clam (Corbicula fluminea)

Zhang, Tianxu; Yan, Zhenguang; Zheng, Xin; Wang, Shuping; Fan, Jun; Liu, Zhengtao

doi:10.1016/j.fsi.2020.02.046

Cited by 110 publications

(40 citation statements)

References 61 publications

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“…In the present study, the 96 h LC50 of unionized ammonium was 12.86 mg/L cumingii, which is higher than those of most fish and shellfish, such as three cyprinid [32], Corbicula fluminea [29], Pseudunio auricularius [26] and Villosa iris glochidia [33]. M over, when the concentration of ammonia reached a high level in the environment excretion of ammonia was inhibited, and the influx of exogenous ammonia was st lated, resulting in the increase of ammonia in the body [34,35].…”

Section: Discussioncontrasting

confidence: 51%

“…Previous studies suggested that glutamine synthesis was an effective ammonia detoxification strategy in fish, such as Oncorhynchus mykiss [25] and Paramisgurnus dabryanus [6,24]. At present, the study of ammonia on freshwater mussels was mainly focused on toxicity assessment, filtration behavior, hemocyte status, DNA damage and apoptosis, cellular energy allocation, and so on [26][27][28][29]. However, the research about the mechanism of ammonia toxicity in bivalves is still limited.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Acute Ammonia Stress on Antioxidant Responses, Histopathology and Ammonia Detoxification Metabolism in Triangle Sail Mussels (Hyriopsis cumingii)

Zhao

Feng

Zhang

et al. 2021

Water

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Ammonia is one of the major pollutants in the aquatic ecosystem. Hyriopsis cumingii has great potential for the restoration of eutrophic water. However, there is no study investigating the effect of ammonia exposure in H. cumingii. The median lethal concentration (96 h LC50) of unionized ammonium was 12.86 mg/L in H. cumingii. In the study, H. cumingii were exposed to 6.43 mg L−1 unionized ammonium (1/2 96 h LC50) for 0, 6, 12, 24, 48, 72, and 96 h. High environment ammonia induced antioxidant response to protect the body from oxidative damage. After exposure to ammonia, there was a same trend of induction followed by inhibition of the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferases (GST) in the hepatopancreas and gills of H. cumingii. However, the antioxidant response could not completely counteract the oxidation effect during the exposure period, resulting in lipid peroxidation (LPO) and tissue injury in the hepatopancreas and gills of H. cumingii eventually. Moreover, this study indicated that glutamine synthetase (GS), glutamate dehydrogenase (GDH), alanine aminotransaminase (ALT), and aspartate aminotransaminase (AST) in the hepatopancreas and gills may play an important role in ammonia detoxification of H. cumingii. Our results will be helpful to understand the mechanism of aquatic toxicology induced by ammonia in shellfish.

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Effects of Acute Ammonia Stress on Antioxidant Responses, Histopathology and Ammonia Detoxification Metabolism in Triangle Sail Mussels (Hyriopsis cumingii)

Zhao

Feng

Zhang

et al. 2021

Water

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“…Exposure to ammonia is considered an environmental stress on aquatic organisms Fisheries and Aquatic Sciences because exposure to ammonia can increase the production of ROS. In general, under normal conditions, ROS can be eliminated quickly by antioxidant enzymes; however, under high concentrations of ammonia, large amounts of ROS cannot be eliminated immediately, which causes an imbalance between ROS and antioxidant enzymes (Zhang et al, 2020). Liang et al (2016) reported that SOD activity in the hepatopancreas of Litopenaeus vannamei exposed to ammonia was significantly decreased, indicating that excessive ROS induced the inhibition of antioxidant enzymes and lost a compensatory mechanism due to excessive ROS.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have reported that ammonia exposure stimulates the overactivation of N-methyl-d-aspartate glutamate receptors in the brain and neurons, which leads to an overproduction of ROS (Li et al, 2016;Zhang et al, 2018). In addition, excess ROS generation can also damage the respiratory chain of the mitochondrial membrane while increasing the calcium concentration, which in turn induces apoptosis (Zhang et al, 2020). Aquatic organisms have antioxidant enzymes to cope with excess ROS, such as superoxide dismutase (SOD) and catalase (CAT).…”

Section: Introductionmentioning

confidence: 99%

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Toxic effects of ammonia on the survival, growth, and oxidative and immune responses in the Pacific abalone, Haliotis discus hannai

Park¹,

Yu²,

Choi³

et al. 2021

Fish Aquat Sci

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The accumulation of ammonia, a consequence of intensive aquaculture activity, can damage cultured animals. We analyzed the survival rates, growth, antioxidant responses, and immune responses of abalones, Haliotis discus hannai (mean shell length 70.2 ± 4.9 mm; mean body weight 36.9 ± 3.6 g), biweekly for four weeks, to determine the accumulated concentrations of ammonia (0, 0.1, 0.2, 0.4, 0.8, and 1.6 mg/L). In our biweekly measurements, a survival rate of ≥ 95% was observed for all concentrations of ammonia. The specific growth rate (SGR) decreased at ≥ 0.8 mg/L (p < 0.05), but the daily increment in shell length (DISL) showed no significant change (p < 0.05). Regarding antioxidant responses, the superoxide dismutase (SOD) activity of the hepatopancreas was increased at ammonia concentrations over 0.8 and 0.2 mg/L (p < 0.05) at two and four weeks, respectively, and the SOD activity of the gills increased at concentrations over 0.4 and 1.6 mg/L (p < 0.05) at four weeks. The catalase (CAT) activity of the hepatopancreas and gills increased at ammonia concentrations > 0.8 mg/L (p < 0.05). Phenoloxidase (PO) activity increased at ammonia concentrations over 0.8 mg/L (p < 0.05), and Lysozyme (LZM) increased at concentrations over 0.8 and 0.4 mg/L (p < 0.05). Overall, our findings indicated that ammonia concentrations over 0.8 mg/L in seawater might damage the SGR, antioxidant responses, and immune responses in H. discus hannai. Our findings suggest the necessity of improvement or reinstallation for abalone aquaculture systems and can be used to assess the toxic effects of ammonia on H. hannai.

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Effects of Different Ammonia Levels on Tribenuron Methyl Toxicity in Daphnia magna

Över

Güven

Taşkın

et al. 2021

Arch Environ Contam Toxicol

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Effects of acute ammonia toxicity on oxidative stress, DNA damage and apoptosis in digestive gland and gill of Asian clam (Corbicula fluminea)

Cited by 110 publications

References 61 publications

Effects of Acute Ammonia Stress on Antioxidant Responses, Histopathology and Ammonia Detoxification Metabolism in Triangle Sail Mussels (Hyriopsis cumingii)

Effects of Acute Ammonia Stress on Antioxidant Responses, Histopathology and Ammonia Detoxification Metabolism in Triangle Sail Mussels (Hyriopsis cumingii)

Toxic effects of ammonia on the survival, growth, and oxidative and immune responses in the Pacific abalone, Haliotis discus hannai

Effects of Different Ammonia Levels on Tribenuron Methyl Toxicity in Daphnia magna

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