Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory

Prediger, Rui Daniel; Fernandes, Marcelo Adorna; Rial, Daniel; Wopereis, Sandro; Pereira, Vitor Silva; Bosse, Tamara S.; Silva, Camila B. Da; Carradore, Renata S.; Machado, Marina S.; Cechinel‐Filho, Valdir; Costa-Campos, Luciane

doi:10.1016/j.jep.2008.09.018

Cited by 48 publications

(27 citation statements)

References 36 publications

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“…When administered intraperitoneally, a dose of 10 mg/kg has been shown to modulate social recognition memory (Prediger et al, 2008). In the present study, the caffeine treated group did not show modulation in either the acquisition or retrieval processes in the social recognition or Morris water maze tasks.…”

Section: Discussioncontrasting

confidence: 52%

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The effects of acute administration of the hydroalcoholic extract of rosemary (Rosmarinus officinalis L.) (Lamiaceae) in animal models of memory

Zanella¹,

Treichel²,

Cansian³

et al. 2012

Braz. J. Pharm. Sci.

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Rosmarinus officinalis (Rosemary) demonstrates antioxidant, antidepressant, diuretic, antinociceptive and antiulcerogenic activities. The present study was designed to examine the effects of the hydroalcoholic extract of R. officinalis on the memory of male mice. The behavioral tasks employed were social recognition (SR), the Morris water maze (MWM) and an inhibitory avoidance task (IA). The treatment with 150 and 300 mg/kg of R. officinalis improved the acquisition phase of learning of a new social memory in the SR task because a decrease was observed in the duration of social investigation. In the Morris water maze, no significant effect was observed on spatial memory when the groups were compared for the time spent in the correct quadrant. In the inhibitory avoidance task, the decrease in the stepdown latencies in the test session indicate that 150 mg/kg of R. officinalis improved long-term memory when administered in the consolidation phase of learning. In conclusion, the present study showed that, the hydroalcoholic extract of R. officinalis at 150 and 300 mg/kg modulated the short-and long-term memories of mice, in a social recognition and inhibitory avoidance task, respectively. This modulator effect was shown to improve learning and memory processes. Uniterms:Rosmarinus officinalis/pharmacognosy. Rosmarinus officinalis/hydroalcoholic extract/ experimental study. Short-term memory/experimental study. Long-term memory/experimental study. Spatial memory/experimental study.Rosmarinus officinalis L. (Alecrim) possui atividade antioxidante, antidepressiva, diurética, antinociceptiva e antiulcerogênica. O presente estudo foi delineado para investigar o efeito do extrato hidroalcoólico de R. officinallis na memória de camundongos machos. Os modelos comportamentais utilizados foram a tarefa de reconhecimento social (RS), labirinto aquático de Morris (MWM) e esquiva inibitória (EI). O tratamento com 150 e 300mg/kg de R. officinallis, mostrou ter efeito positivo na aquisição de uma nova memória social, na tarefa de reconhecimento social, mostrando redução significativa do tempo de investigação social. No labirinto aquático de Morris, não foi visto efeito significativo na memória espacial, ao comparar o tempo desprendido no quadrante correto entre os diferentes tratamentos. Na esquiva inibitória a latência de descida da plataforma, observada na sessão teste, sugere que o tratamento com a dose 150 mg/kg de R. officinallis tem um efeito positivo na memória de longo prazo, quando administrada na fase de consolidação. Concluise que o extrato de R. officinalis nas doses de 150 e 300 mg/kg foi capaz de modular as memórias de curto e longo prazo dos roedores nas tarefas de reconhecimento social e esquiva inibitoria, respectivamente, e esse efeito modulatório melhorou os processos de aprendizado e memória. Unitermos INTRODUCTIONRosmarinus officinalis (Lamiaceae), rosemary, is a perennial herb native to the Mediterranean region but is widely distributed in many parts of the world, including Brazil (Nissen et al., 2000). Amo...

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Section: Discussioncontrasting

confidence: 52%

“…Short-term social memory was assessed with a slightly modified social recognition task (SR), described by Prediger (Prediger et al, 2008). The adult mice were housed in plastic cages and remained in identical environments until individualized on the day of the task.…”

Section: Memory Models Social Recognition Taskmentioning

confidence: 99%

The effects of acute administration of the hydroalcoholic extract of rosemary (Rosmarinus officinalis L.) (Lamiaceae) in animal models of memory

Zanella¹,

Treichel²,

Cansian³

et al. 2012

Braz. J. Pharm. Sci.

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“…The integrity of the nigrostriatal dopaminergic system is important for the completion of this task, and the authors also show decreased tyrosine hydroxylase staining in the SNpc. 139 …”

Section: Behavioral Studies On Mn-induced Neurotoxicitymentioning

confidence: 99%

Manganese-induced neurotoxicity: from C. elegans to humans

Chen

Chakraborty

Peres

et al. 2014

Toxicology Research

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Manganese (Mn) is one of the most abundant metals on the earth. It is required for normal cellular activities, but overexposure leads to toxicity. Neurons are more susceptible to Mn-induced toxicity than other cells, and accumulation of Mn in the brain results in Manganism that presents with Parkinson's disease (PD)-like symptoms. In the last decade, a number of Mn transporters have been identified, which improves our understanding of Mn transport in and out of cells. However, the mechanism of Mn-induced neurotoxicity is only partially uncovered, with further research needed to explore the whole picture of Mn-induced toxicity. In this review, we will address recent progress in Mn-induced neurotoxicity from C. elegans to humans, and explore future directions that will help understand the mechanisms of its neurotoxicity.

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“…In addition to flavonoids as quercetin and rutin and phenolic compounds as chlorogenic and caffeic acids, yerba mate is also rich in caffeine and saponins [10]. The literature data have demonstrated that I. paraguariensis can improve the cognition of rats treated with acute administration of hydroalcoholic extract probably through its antagonist's action on adenosine receptors [11]. Another study showed that an infusion of I. paraguariensis can improve the memory of rats treated with haloperidol and this effect was related to an indirect modulation of oxidative stress [12].…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-Like Effect ofIlex paraguariensisin Rats

Reis¹,

Neto

Cattani

et al. 2014

BioMed Research International

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In this study, we investigated the possible antidepressant-like effect of I. paraguariensis in rats. Rats were treated for four weeks with an aqueous extract of I. paraguariensis in drinking water, following the traditional preparation of this beverage. After the period of treatment, behavioral (elevated plus-maze, open field test, and forced swimming test) and biochemical parameters (lipid peroxidation assay, thiol content, vitamin C levels, and monoamine oxidase activity) were evaluated. Animals were also analyzed on forced swimming test after 24 hours of I. paraguariensis intake. An additional group was injected with selegiline 24 hours and 30 minutes before forced swimming test as positive control. HPLC analysis revealed the profile of I. paraguariensis extract. I. paraguariensis reduced the immobility time on forced swimming test without significant changes in locomotor activity in the open field test. Any anxiolytic/anxiogenic effect of I. paraguariensis was observed in rats through the elevated plus-maze test. The antidepressant-like effect of I. paraguariensis was not accompanied by inhibitory effect on monoamine oxidase activity. There were no significant alterations on lipid peroxidation, thiol content, and vitamin C levels among the groups. In conclusion, aqueous extract of I. paraguariensis decreases the time of immobility in rats suggesting an antidepressant-like effect.

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Effects of acute administration of the hydroalcoholic extract of mate tea leaves (Ilex paraguariensis) in animal models of learning and memory

Cited by 48 publications

References 36 publications

The effects of acute administration of the hydroalcoholic extract of rosemary (Rosmarinus officinalis L.) (Lamiaceae) in animal models of memory

The effects of acute administration of the hydroalcoholic extract of rosemary (Rosmarinus officinalis L.) (Lamiaceae) in animal models of memory

Manganese-induced neurotoxicity: from C. elegans to humans

Antidepressant-Like Effect ofIlex paraguariensisin Rats

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