Antidepressant-Like Effect of<i>Ilex paraguariensis</i>in Rats

Reis, Elizete de Moraes; Neto, Francisco Waldomiro Schreiner; Cattani, Vitória Berg; Peroza, Luis Ricardo; Busanello, Alcindo; Leal, Caroline Queiroz; Boligon, Aline Augusti; Lehmen, Tassia; Libardoni, Milena; Athayde, Margareth Linde; Fachinetto, Roselei

doi:10.1155/2014/958209

Cited by 30 publications

(11 citation statements)

References 49 publications

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“…Body weight gain was lower in rats supplemented with Ilex paraguariensis extract. Similar data was observed by Pang et al (2008), indicating that dietary supplementation with Ilex paraguariensis extract administered to obese rats induced by high-fat diet was able to significantly reduce body weight gain, plasma triacylglycerides, glucose,, along with reduction on anti-inflammatory markers (Luz et al, 2016), and antidepressant-like effects (Reis et al, 2014). According to Hetzler et al (1990) the amount of caffeine present in Ilex paraguariensis could be responsible for the significant decrease in the amount of epididymal and abdominal fat.…”

Section: Discussionsupporting

confidence: 67%

Ilex paraguariensis extract prevents body weight gain in rats fed a high-fat diet

et al. 2019

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Studies have shown that drinks containing Ilex paraguariensis extract can promote many benefits in animals and in humans. The present study aimed to evaluate in vivo effects of Ilex paraguariensis extract on metabolic profile, obesity prevention and expression of genes related with adipogenesis and lipogenesis in Wistar female rats fed a high-fat diet. For this experiment 32 Wistar female rats with normal weight were used and randomly separated into four groups: diet (standard or high-fat) and treatment (water or Ilex paraguariensis extract) for 34 days. The rats receiving Ilex paraguariensis extract had lower body weight compared to the control group in both diets. Likewise, there was a reduction in triglycerides in the groups fed high-fat diet and treated with Ilex paraguariensis extract. The creatinine levels were lower in the groups treated with Ilex paraguariensis and in high-fat diet. Ot was observed an increased liver gene expression for Fas and Scd1 in the group treated with hyperlipid diet + Ilex paraguariensis. Ot can be concluded that Ilex paraguariensis extract decreased body weight gain in both control and high-fat diets, reduced plasma triglycerides and creatinine levels and increased liver expression of genes related to lipogenesis.

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Section: Discussionsupporting

confidence: 67%

Ilex paraguariensis extract prevents body weight gain in rats fed a high-fat diet

et al. 2019

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“…The limit of detection (LOD) and limit of quantification (LOQ) were calculated based on the standard deviation of the responses and the slope using three independent analytical curves. LOD and LOQ were calculated as 3.3 and 10 σ/ S , respectively, where σ is the standard deviation of the response and S is the slope of the calibration curve [Reis et al . 2014].…”

Section: Methodsmentioning

confidence: 99%

Differential protection of black-seed oil on econucleotidase, cholinesterases and aminergic catabolizing enzyme in haloperidol-induced neuronal damage of male rats

Akintunde

Irechukwu

2016

Therapeutic Advances in Drug Safety

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“…A forced swimming test was performed in accordance with the method of Elizete et al. [22] . The test was performed after 24 hours of treatment.…”

Section: Methodsmentioning

confidence: 99%

Hyperhomocysteinemia Is a Result, Rather than a Cause, of Depression under Chronic Stress

Chengfeng

Liu²,

Wang

et al. 2014

PLoS ONE

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BackgroundAlthough the accumulation of homocysteine (Hcy) has been implicated in the pathogenesis of depression, whether Hcy is directly involved and acts as the primary cause of depressive symptoms remains unclear. The present study was designed to clarify whether increased Hcy plays an important role in stress-induced depression.ResultsWe employed the chronic unpredictable mild stress model (CUMS) of depression for 8 weeks to observe changes in the plasma Hcy level in the development of depression. The results showed that Wistar rats exposed to a series of mild, unpredictable stressors for 4 weeks displayed depression-like symptoms such as anhedonia (decreased sucrose preferences) and a decreased 5-Hydroxy Tryptophan (5-HT) concentration in the hippocampus. At the end of 8 weeks, the plasma Hcy level increased in the CUMS rats. The anti-depressant sertraline could decrease the plasma Hcy level and improve the depression-like symptoms in the CUMS rats. RhBHMT, an Hcy metabolic enzyme, could decrease the plasma Hcy level significantly, although it could not improve the depressive symptoms in the CUMS rats.ConclusionsThe results obtained from the experiments did not support the hypothesis that the increased Hcy concentration mediated the provocation of depression in CUMS rats, and the findings suggested that the increased Hcy concentration in the plasma might be the result of stress-induced depression.

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Antidepressant-Like Effect ofIlex paraguariensisin Rats

Cited by 30 publications

References 49 publications

Ilex paraguariensis extract prevents body weight gain in rats fed a high-fat diet

Ilex paraguariensis extract prevents body weight gain in rats fed a high-fat diet

Differential protection of black-seed oil on econucleotidase, cholinesterases and aminergic catabolizing enzyme in haloperidol-induced neuronal damage of male rats

Hyperhomocysteinemia Is a Result, Rather than a Cause, of Depression under Chronic Stress

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