Differential protection of black-seed oil on econucleotidase, cholinesterases and aminergic catabolizing enzyme in haloperidol-induced neuronal damage of male rats

Abstract

We concluded that essential black-seed oil enhanced the wellness of aminergic, purinergic and cholinergic neurotransmissions of haloperidol-induced neuronal damage in rats.

Functional Oil from Black Seed Differentially Inhibits Aldose-reductase and Ectonucleotidase Activities by Up-regulating Cellular Energy in Haloperidol-induced Hepatic Toxicity in Rat Liver

“…This result has already been published according to the previous work by Akintunde and Irechukwu 9 . HPLC phenolic profile of the extract revealed the presence of the gallic acid, catechin, chlorogenic acid, caffeic acid, orientin, rutin, quercitrin, quercetin and luteolin 9 .…”

“…This result has already been published according to the previous work by Akintunde and Irechukwu 9 . HPLC phenolic profile of the extract revealed the presence of the gallic acid, catechin, chlorogenic acid, caffeic acid, orientin, rutin, quercitrin, quercetin and luteolin 9 . Also, gas chromatography-mass spectrum GC-MS had formerly indicated the presence carvone, alfa-pinene, sabininene, p-cymene, β-pinene, and carotene which could be biotransformed into vitamin A 25 .…”

“…The present study used the innovative approach of differential hepatic pharmacology to allow the prevention of liver toxicity/ and or hepatic failure to the beneficial activities of essential oil from black seed. Related effect has been demonstrated in our previous work using essential oil as neuron-stimulant, cyto-protector agent which protect aminergic metabolizing enzymes and mediation of neuronal antioxidative damage both in vivo and in vitro 9 . Excitingly, in the current study, differential treatment with functional oil from black seed significantly lowered AR activity than HAL induced liver toxicity group, indicating that ability to inhibit AR was most efficacious by co-treatment.…”

“…The lowest rate of hepatic ATP hydrolysis to form adenosine was found in the differential treatment with functional oil than HAL induced liver toxicity group. Elevations of these enzymes have previously been discovered in the livers of compromised patients when compared with normal individuals 9,31 . Additionally, the current investigation shows that differential pre, co and EO treatments upregulated the activity of LDH-marker of ATP production in liver when compared with HAL induced liver toxicity group.…”

“…Furthermore, FO from black seed was shown to act as neuron-stimulant and cytoprotector agent, protecting aminergic metabolizing enzymes and membrane lipids against oxidative damage both in vivo and in vitro 9 .…”