Functional Oil from Black Seed Differentially Inhibits Aldose-reductase and Ectonucleotidase Activities by Up-regulating Cellular Energy in Haloperidol-induced Hepatic Toxicity in Rat Liver

Kehinde, Akintunde Jacob

doi:10.5650/jos.ess17036

Cited by 11 publications

(4 citation statements)

References 32 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These outcomes indicate that treatment with phenolic C-ZAMB leaf fraction was able to avert low levels of ATP in both the brain and ovary as well as sub-fertility challenges instigated by EOMABRSL exposure. Our results, therefore, demonstrated that 400 mg/kg of C-ZAMB have the potential to inhibit the activity of E51NT (a marker of ATP hydrolysis) initiated by dissimilar agents, such diabetic induced agents [ 58 ], acetonitrile, AlCl3 associated with d -galactose and anti-psychotic drugs [ 51 , 54 ]. It is imperative to mention that super addition or synergistic interaction of gallic acid, caffeic acid, quercetin, luteolin, and apigenin could be responsible for the metabolic inhibition of eco-5 1 -nucleotidase activity.…”

Section: Discussionmentioning

confidence: 83%

“…One of the imperative indices with a fundamental role in ATP stability and its hydrolysis is the eco-51 nucleotidase enzyme [ 54 ]. Studies have proven that some compounds present in diets and polluted water, such as organic pollutants and heavy metals, are associated with heightened E51NT activity and ATP diminution [ 51 , 54 ]. Therefore, we hypothesized that the up-regulation of this enzyme could be one of the pathological bases for cerebro-ovarian toxicity when exposed to mixtures of toxicants.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic depletion of synaptosomal enzymes linked with neurotoxicity and ovarian dysfunction by phenolic antioxidants of Croton zambsicus leaves in rats exposed to chronic mixture of anthropogenic toxicant

et al. 2021

View full text Add to dashboard Cite

A complex mixture of organic contaminants and metals is associated with neuron-fertility disorders and studies have demonstrated that phenolic antioxidants from herbal origin, possesses a strong protective potential. This study aimed to investigate the protection of phenolic croton zambesicus (C-ZAMB) leaves against neuro-ovarian damage in rats exposed to chronic mixture of anthropogenic toxicants (EOMABRSL). The animals were divided into five groups (n = 10): Group I was given 0.5 ml of distilled water only; Group II received 0.5 ml of EOMABRSL for 98 days; Group III received 0.5 ml of EOMABRSL for 70 days and withdrew for 28 days; Group IV received 0.5 ml of EOMABRSL for 70 days +400 mg/kg phenolic C-ZAMB for 28 days; Group V received 400 mg/kg C-ZAMB only for 28 days via oral route. Both non-withdrawal and withdrawal EOMABRSL-exposed animals exhibited neuro-ovarian impairment by up-regulating neuronal 5 1 eco-nucleotidase (5 1 ENT), acetylcholinesterase (AChE), butrylcholinesterase (BuChE), synaptosomal monoamine oxidase-A (MAO-A) with altered cerebral antioxidants. Similarly, exposure to EOMABRSL for 98 and 70 days caused ovarian injury by amplifying the activity of 5 1 ENT with corresponding decline of fertility index, lactate dehydrogenase (LDH) and Δ5 17β-hydroxyl steroid dehydrogenase (Δ517β-HSD). EOMABRSL intoxication also increased the neuro-ovarian MDA content with reduced numbers of neonates. Phenolic antioxidants from C-ZAMB leaves identified by High Pressure Liquid Chromatography (HPLC) ameliorated the chronic EOMABRSL intoxication. The treatment also prevented ovarian lesions by depleting MDA content and improved antioxidant status. Thus, confirming its neuro-ovarian protection.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Metabolic depletion of synaptosomal enzymes linked with neurotoxicity and ovarian dysfunction by phenolic antioxidants of Croton zambsicus leaves in rats exposed to chronic mixture of anthropogenic toxicant

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Demonstrating the presence of BPA in AH seems to be important from the point of view of many potential threats related to BPs intoxication starting from direct oxidative damage [ 81 ], changing the activity of many enzymes [ 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ], deregulation of the gene expression [ 55 , 92 ], up to the increase in pro-inflammatory cytokines [ 93 ], and apoptotic proteins [ 94 ].…”

Section: Discussionmentioning

confidence: 99%

“…Decreased NOS expression has been associated with the development of hypertensive retinopathy, cataracts, glaucoma, vitreous hemorrhage [ 86 ], and the cell proliferation (hyperplasia) of ocular cancer and degeneration of retinocyte outgrowth, with the deterioration of conjunctiva and lens [ 87 ]. Another enzyme that is associated with BPA intoxication is arginase, the increased expression of which can trigger inflammatory processes [ 88 ] that lead to the development of cataracts. Another enzyme whose activity increases under the influence of BPA is phosphodiesterase-5 (PDE-5).…”

Section: Discussionmentioning

confidence: 99%

The First Evidence on the Occurrence of Bisphenol Analogues in the Aqueous Humor of Patients Undergoing Cataract Surgery

Flieger

Śniegocki

Dolar-Szczasny

et al. 2022

JCM

View full text Add to dashboard Cite

Human exposure to BPs is inevitable mostly due to contaminated food. In this preliminary study, for the first time, the presence of bisphenols (BPs) in aqueous humor (AH) collected from 44 patients undergoing cataract surgery was investigated. The measurements were performed using a sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS). Chromatographic separation was achieved using a reverse-phase column and a gradient elution mode. Multiple reaction monitoring (MRM) was used. The method was validated for bisphenol A (BPA) and bisphenol F (BPF). The limits of quantification (LOQs) of both investigated analytes were 0.25 ng mL−1. The method was linear in the range of 0.25–20.0 ng mL−1 with correlation coefficients (R2) higher than 0.98. Recovery of analytes was in the range of 99.9 to 104.3% and intra-assay and inter-assay precision expressed by relative standard deviations (RSD%) were less than 5%. BPA was detected in 12 AH samples with mean concentrations of 1.41 ng mL−1. BPF was not detected at all. Furthermore, two structural isomers termed BPA-1, and BPA-2 were identified, for the first time, in 40.9% of the AH samples, with almost twice higher mean concentrations of 2.15 ng mL−1, and 2.25 ng mL−1, respectively. The total content of BPs were higher in patients with coexisting ocular pathologies such as glaucoma, age-related macular degeneration (AMD), and diabetes in comparison to cataracts alone. However, the difference between these groups did not reach statistical significance (p > 0.05). Performed investigations indicate the need for further research on a larger population with the aim of knowing the consequences of BPs’ accumulation in AH for visual function.

show abstract

Haloperidol Reduces the Activity of Complement and Induces the Anti-Inflammatory Transformation of Peritoneal Macrophages in Rats

Cheremnykh

Иванов

Sokolov

et al. 2019

J Neuroimmune Pharmacol

View full text Add to dashboard Cite

Functional Oil from Black Seed Differentially Inhibits Aldose-reductase and Ectonucleotidase Activities by Up-regulating Cellular Energy in Haloperidol-induced Hepatic Toxicity in Rat Liver

Cited by 11 publications

References 32 publications

Metabolic depletion of synaptosomal enzymes linked with neurotoxicity and ovarian dysfunction by phenolic antioxidants of Croton zambsicus leaves in rats exposed to chronic mixture of anthropogenic toxicant

Metabolic depletion of synaptosomal enzymes linked with neurotoxicity and ovarian dysfunction by phenolic antioxidants of Croton zambsicus leaves in rats exposed to chronic mixture of anthropogenic toxicant

The First Evidence on the Occurrence of Bisphenol Analogues in the Aqueous Humor of Patients Undergoing Cataract Surgery

Haloperidol Reduces the Activity of Complement and Induces the Anti-Inflammatory Transformation of Peritoneal Macrophages in Rats

Contact Info

Product

Resources

About