Effects of active pharmaceutical ingredients mixtures in mussel Mytilus galloprovincialis

González-Rey, María; Mattos, Jacó Joaquim; Piazza, Clei Endrigo; Bainy, Afonso Celso Dias; Bebianno, Maria João

doi:10.1016/j.aquatox.2014.02.006

Cited by 72 publications

(26 citation statements)

References 67 publications

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“…On the contrary, others have found down-regulation of these genes (e.g. Chen et al, 2015;Gonzalez-Rey et al, 2014;Sun et al, 2014). These differences may be attributed to the particular conditions of each experiment, to the pollutant and to the tested species.…”

Section: Resultsmentioning

confidence: 81%

Evaluation of the estrogenic and oxidative stress effects of the UV filter 3-benzophenone in zebrafish (Danio rerio) eleuthero-embryos

Rodrı́guez-Fuentes

Sandoval-Gío

Arroyo-Silva

et al. 2015

Ecotoxicology and Environmental Safety

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Section: Resultsmentioning

confidence: 81%

Evaluation of the estrogenic and oxidative stress effects of the UV filter 3-benzophenone in zebrafish (Danio rerio) eleuthero-embryos

Rodrı́guez-Fuentes

Sandoval-Gío

Arroyo-Silva

et al. 2015

Ecotoxicology and Environmental Safety

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“…It is interesting that trends in the protein abundance/activity data is not reflective of respective mRNA expressions, though this is not unique to this study (Frederich et al, 2009;Jost et al, 2012;Xing et al, 2013;Gonzalez-Rey et al, 2014). Genomic and functional responses represent temporally different effects.…”

Section: Ampk Protmentioning

confidence: 90%

AMP-activated protein kinase is a biomarker of energetic status in freshwater mussels exposed to municipal effluents

Goodchild

Frederich

Zeeman

2015

Science of The Total Environment

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“…Its expression was downregulated after increasing concentrations of β-naphthoflavone (BNF) and upregulated after exposure to Cu (Snyder 2000;Gonzalez-Rey et al 2014). Additionally, the CYP4 gene family is involved in fatty acid and prostaglandins metabolism.…”

Section: Cyp4y1 Gene Transcription Profilementioning

confidence: 99%

“…Since this protein is usually quite stable, it is successfully applied as a reference gene (Gonzalez-Rey et al 2014). In this case, since it showed some variation and therefore it was tested as a gene of interest.…”

Section: Ef1 Gene Transcription Profilementioning

confidence: 99%

Is gene transcription in mussel gills altered after exposure to Ag nanoparticles?

Bebianno

González-Rey

Gomes

et al. 2015

Environ Sci Pollut Res

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Nanotechnology is a rapid field of development with the enhancement of the production of different types of nanoparticles (NPs) applied in several industrial and commercial applications which increase the risk of their presence in the aquatic environment. Ag NPs have a wide application in everyday life products. However, there is concern about the exposure effects on aquatic organisms to these NPs. Therefore, this study aims to assess gene transcription alterations in mussels Mytilus galloprovincialis gills exposed for 2 weeks to Ag NPs (42 ± 10 nm, 10 μg.L(-1)). The genes were selected based on previous biomarkers and proteomic results and included superoxide dismutase (SOD), catalase (CAT), glutathione transferase (GST), caspase 3/7-1 (CAS), cathepsin L (CATH), heat-shock protein 70 (HSP 70), cytochrome P450 4YA (CYP 4YA), the elongation factor (EF1), actin and α- tubulin. No significant changes in gene transcription profiles were observed after exposure of M. galloprovincialis to Ag NPs for 15 days. The lack of significant gene transcription responses is in light with previous results obtained for mussels exposed to these NPs and may be related to the fact that enzyme kinetics and relative abundance of proteins (increase of antioxidant enzymes and metalllothioneins (MTs) with the time of exposure) do not always directly reflect their relative mRNA levels. Nevertheless, their overall expression maintenance may signify that, at end of the exposure period (15 days), the transcription of the respective genes is no longer required, pointing out to a possible adaptation effect to nanoparticles or due to the levels of Ag NPs accumulated in this tissue at this exposure time. This study highlights that gene transcription application and role as an additional and/or alternative end point approach is important to understand the mode of action of these emergent contaminants in aquatic organisms. However, in future studies, the time window needs to be adjusted, as genes are likely to respond earlier to the nanoparticle exposure.

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Effects of active pharmaceutical ingredients mixtures in mussel Mytilus galloprovincialis

Cited by 72 publications

References 67 publications

Evaluation of the estrogenic and oxidative stress effects of the UV filter 3-benzophenone in zebrafish (Danio rerio) eleuthero-embryos

Evaluation of the estrogenic and oxidative stress effects of the UV filter 3-benzophenone in zebrafish (Danio rerio) eleuthero-embryos

AMP-activated protein kinase is a biomarker of energetic status in freshwater mussels exposed to municipal effluents

Is gene transcription in mussel gills altered after exposure to Ag nanoparticles?

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