Effects of active immunization of ram lambs and bull calves against synthetic luteinizing hormone releasing hormone

Jeffcoate, I.A.; Lucas, J.M.S.; Crighton, D. B.

doi:10.1016/0093-691x(82)90050-4

Cited by 52 publications

(22 citation statements)

References 10 publications

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“…As it has been shown in many investigations published during the last years [3][4][5][6][7][8][9][10]17,20,[29][30][31][32][33][34] vaccination against GnRF was able to induce an increase in anti-GnRF antibody titer.…”

Section: Discussionmentioning

confidence: 99%

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Vaccination against gonadotropin-releasing factor (GnRF) with Bopriva significantly decreases testicular development, serum testosterone levels and physical activity in pubertal bulls

Janett

Gerig

Tschuor³

et al. 2012

Theriogenology

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The aim of this study was to evaluate the effects of vaccination against gonadotropin-releasing factor (GnRF) on testicular development, testosterone secretion, and physical activity in pubertal bulls. The experiment was performed using 44 bulls aged between 6 and 7 mo. Twenty-three animals were vaccinated twice 4 wk apart with 1 mL of Bopriva (Pfizer, Animal Health, Parkville, Australia) and 21 bulls served as matched controls. Serum GnRF antibody titer and testosterone concentration as well as body weight and scrotal circumference were determined in all bulls for 24 wk from the first vaccination. In addition, physical activity was analyzed in 11 vaccinated and in 10 control animals using the ALPRO DeLaval activity meter system (DeLaval AG, Sursee, Switzerland). The results show that vaccination significantly (P < 0.05) influenced all parameters evaluated except body weight. Antibody titers to GnRF began to rise 2 wk after the first vaccination and reached peak values 2 wk after the second injection. Significant group differences in anti-GnRF titer were present for 22 wk following the first vaccination. Testosterone concentrations were significantly lower between weeks 6 to 24 after first vaccination in bulls with Bopriva compared with control animals. In vaccinated bulls testicular development was impaired after the second injection and scrotal circumference was significantly smaller between weeks 8 to 24 after first vaccination. Physical activity of vaccinated bulls was reduced after the booster injection with significant group differences for a continuous period of 106 days. In conclusion, vaccination against GnRF with Bopriva in pubertal bulls decreased testosterone levels in peripheral blood, testicular development, and physical activity but did not affect weight gain. AbstractThe aim of this study was to evaluate the effects of vaccination against gonadotropinreleasing factor (GnRF) on testicular development, testosterone secretion and physical activity in pubertal bulls. The experiment was performed using 44 bulls aged between 6 and 7 months. Twenty-three animals were vaccinated twice 4 weeks apart with 1 mL of Bopriva ® (Pfizer Animal Health, Australia) and 21 bulls served as matched controls. Serum GnRF antibody titer and testosterone concentration as well as body weight and scrotal circumference were determined in all bulls for 24 weeks from the first vaccination. In addition, physical activity was analyzed in 11 vaccinated and in 10 control animals using the ALPRO  DeLaval activity meter system (DeLaval AG, Sursee, Switzerland). The results show that vaccination significantly (P < 0.05) influenced all parameters evaluated except body weight. Antibody 2 titers to GnRF began to rise 2 weeks after the first vaccination and reached peak values 2 weeks after the second injection. Significant group differences in anti-GnRF titer were present for 22 weeks following the first vaccination. Testosterone concentrations were significantly lower between weeks 6 to 24 after first vaccination in bulls w...

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Section: Discussionmentioning

confidence: 99%

“…The suppression of reproductive function using an anti-GnRF vaccine has been demonstrated in numerous studies in cattle [3][4][5][6][7][8][9][10][11][12][13], sheep [10,[14][15][16][17][18][19][20][21], pig [22][23][24][25][26][27][28], horse [29][30][31][32][33][34] and in wild animals [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Vaccination against gonadotropin-releasing factor (GnRF) with Bopriva significantly decreases testicular development, serum testosterone levels and physical activity in pubertal bulls

Janett

Gerig

Tschuor³

et al. 2012

Theriogenology

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“…It points to the remarkable sensitivity of the testis during this phase to FSH or alternatively suggests that the exposure of the testis to inhibin directly influences testicular growth. It has been clearly shown that normal testicular development in rams is dependent on the gonadotrophins (Courot 1967, Courot & Ortavant 1981, Jeffcoate et al 1982, Tilbrook et al 1993c. The results of the current experiment specifically illustrate the importance of FSH for testicular development because only FSH, and not LH, was reduced following treatment with hr-inhibin A.…”

Section: Discussionmentioning

confidence: 99%

Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin

Tilbrook

Kretser

Clarke³

1999

Journal of Endocrinology

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We have investigated the effectiveness of human recombinant inhibin A (hr-inhibin A) to suppress the secretion of follicle-stimulating hormone (FSH) in ram lambs from 1 to 18 months of age. Seventeen rams (nine castrated, eight intact) were used. At 1, 3, 6, 9, 12 and 18 months of age the rams were given an i.v. injection of either vehicle or hr-inhibin A (0·64 µg/kg). Blood samples were taken over 24 h. Plasma concentrations of FSH were suppressed in castrated and intact rams following injection of hr-inhibin A with maximal suppression occurring 6 h after injection. Vehicle injection had no effect. At 12 months of age the suppression in FSH was most rapid in castrated rams and was maximal in intact rams. The clearance rate of inhibin was greatest at older ages but during the period of seasonally induced testicular activity, there was a significant decrease in the inhibin clearance. The testicular weight was reduced in rams treated with hr-inhibin A, indicating the importance of FSH for testicular development during the pubertal period. There was no effect of hr-inhibin A on plasma concentrations of luteinizing hormone. We conclude that inhibin is capable of suppressing the secretion of FSH in rams from 1 month of age onwards and that the pituitary gland becomes maximally responsive to the actions of inhibin by the age of puberty.

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“…Durch die Impfung wurde das Hodenwachstum gehemmt und das Verhalten beeinflusst. Ähnliche Ergebnisse finden sich auch in früheren Untersuchungen mit unterschiedlichen Impfstoffen und Versuchsanordnungen, wobei Verhaltensänderungen nicht oder nur subjektiv erhoben wurden (Jeffcoate et al, 1982;Finnerty et al, 1994;Jago et al, 1997;Huxsoll et al, 1998). Eine aktuelle Studie mit einem Aktivitätsmesssystem (ALPRO DeLaval, DeLaval, Sursee) hat eindrücklich gezeigt, dass geimpfte Stiere nach der 2.…”

Section: Involution Des Hodenparenchyms Kann Nach Burdizzokastration unclassified

“…Hemmung der Hodenfunktion (Jeffcoate et al, 1982;Brown et al, 1994;Kiyma et al, 2000;Janett et al, 2003 Biotechnol .1990, 4:166-170, 176.…”

Section: Auch Beim Widderlamm Bewirkt Die Impfung Gegen Gnrh Eine Zuvunclassified

Die Kastration beim männlichen Kalb und Lamm

Steiner

Janett

2013

Schweizer Archiv für Tierheilkunde

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Local anesthesia is not necessary for this procedure. Ram lambs should be castrated at the age of 14 days or less, at least 10 minutes after local anesthesia with lidocaine, applying a rubber ring. The toxic dose of 4mg lidocaine / kg BW (corresponds to 1 ml lidocaine 2% per lamb of 5kg BW) should not be exceeded. Concurrently, a NSAID (off label use) and Tetanus-serum should be administered systemically. Immunization against GnRH represents an animal-friendly and economically feasible alternative to rubber ring castration. With two immunizations at an interval of 3-4 weeks testicular development can be inhibited for at least 3 months and the onset of puberty clearly delayed. However, a specific vaccine for use in ruminants is currently registered neither in Switzerland nor in Europe.2

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Effects of active immunization of ram lambs and bull calves against synthetic luteinizing hormone releasing hormone

Cited by 52 publications

References 10 publications

Vaccination against gonadotropin-releasing factor (GnRF) with Bopriva significantly decreases testicular development, serum testosterone levels and physical activity in pubertal bulls

Vaccination against gonadotropin-releasing factor (GnRF) with Bopriva significantly decreases testicular development, serum testosterone levels and physical activity in pubertal bulls

Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin

Die Kastration beim männlichen Kalb und Lamm

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