Effects of Active and Passive Hypoxic Conditioning for 6 Weeks at Different Altitudes on Blood Lipids, Leptin, and Weight in Rats

Du, Xia; Girard, Olivier; Fan, Rong; Ma, Fuhai

doi:10.1089/ham.2020.0003

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…However, the effect of hypoxic exercise in improving HDL and LDL was significantly higher compared with the effect of normoxic exercise. Du et al (2020) reported consistent findings that increase in altitude was correlated with decrease in TG levels and the decrease was highly correlated hypoxic exposure, however, the effects on TC, LDL, and HDL levels were not correlated with degree of hypoxic exposure.…”

Section: Discussionsupporting

confidence: 56%

BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats

Feng

Wang

et al. 2022

Front. Physiol.

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In recent years, obesity has become an important risk factor for human health; how to effectively prevent and reduce the occurrence of obesity is a hot research topic in recent years. Hypoxic training effectively improves abnormalities of lipid metabolism caused by obesity. The current study explored the effects of hypoxic training on BAIBA secretion and white fat browning in inguinal fat in obese rats. Analyses were performed by HPLC/MS/MS—MS/MS, RT-q PCR and western blot methods. The findings showed that 4 weeks of hypoxic training reduced body weight, Lee’s index, and regulated blood lipid profile in obese rats. Hypoxic training up-regulated BAIBA concentration in gastrocnemius muscle and circulation in obese rats. Hypoxic training significantly upregulated expression of PPARα and UCP-1 in inguinal fat of obese rats and increased white fat browning. The findings showed that BAIBA may involve in improveing blood lipid profile and white fat browning by modulating PPARα and UCP-1 expression.

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Section: Discussionsupporting

confidence: 56%

BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats

Feng

Wang

et al. 2022

Front. Physiol.

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“…The study failed to identify any significant IHHE effects on anthropometric indices in MS patients, as there was no significant reduction in body weight and waist and hip circumferences, which is likely to be due to the limited (3 week) course duration. In clinical trials of X.Du [48], C.Lisamore [22], and N. Muangritdech [42] using exercise training combined with IHT in patients with obesity, hypertension and MS, the minimum period required to reduce body weight and fat mass was 6-8 weeks [22,42,48]. Nevertheless, when comparing the shifts in anthropometric indices, some reliable differences were noted, namely their decrease in the IHHE group with almost no changes in control.…”

Section: Discussionmentioning

confidence: 99%

Intermittent Hypoxic-Hyperoxic Exposures Effects in Patients with Metabolic Syndrome: Correction of Cardiovascular and Metabolic Profile

et al. 2022

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The aim of this study was to evaluate efficacy and applicability of the “intermittent hypoxic-hyperoxic exposures at rest” (IHHE) protocol as an adjuvant method for metabolic syndrome (MS) cardiometabolic components. A prospective, single-center, randomized controlled clinical study was conducted on 65 patients with MS subject to optimal pharmacotherapy, who were randomly allocated to IHHE or control (CON) groups. The IHHE group completed a 3-week, 5 days/week program of IHHE, each treatment session lasting for 45 min. The CON group followed the same protocol, but was breathing room air through a facial mask instead. The data were collected 2 days before, and at day 2 after the 3-week intervention. As the primary endpoints, systolic (SBP) and diastolic (DBP) blood pressure at rest, as well as arterial stiffness and hepatic tissue elasticity parameters, were selected. After the trial, the IHHE group had a significant decrease in SBP and DBP (Cohen’s d = 1.15 and 0.7, p < 0.001), which became significantly lower (p < 0.001) than in CON. We have failed to detect any pre-post IHHE changes in the arterial stiffness parameters (judging by the Cohen’s d), but after the intervention, cardio-ankle vascular indexes (RCAVI and LCAVI) were significantly lowered in the IHHE group as compared with the CON. The IHHE group demonstrated a medium effect (0.68; 0.69 and 0.71 Cohen’s d) in pre-post decrease of Total Cholesterol (p = 0.04), LDL (p = 0.03), and Liver Steatosis (p = 0.025). In addition, the IHHE group patients demonstrated a statistically significant decrease in pre-post differences (deltas) of RCAVI, LCAVI, all antropometric indices, NTproBNP, Liver Fibrosis, and Steatosis indices, TC, LDL, ALT, and AST in comparison with CON (p = 0.001). The pre-post shifts in SBP, DBP, and HR were significantly correlated with the reduction degree in arterial stiffness (ΔRCAVI, ΔLCAVI), liver fibrosis and steatosis severity (ΔLFibr, ΔLS), anthropometric parameters, liver enzymes, and lipid metabolism in the IHHE group only. Our results suggested that IHHE is a safe, well-tolerated intervention which could be an effective adjuvant therapy in treatment and secondary prevention of atherosclerosis, obesity, and other components of MS that improve the arterial stiffness lipid profile and liver functional state in MS patients.

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“…Haufe et al [76] suggested that the interaction of exercise and hypoxia may have a much greater effect on blood TG levels compared to either stimulus alone. For example, IHT training performed at moderate altitudes (2000-3000 m) has been shown to lead to a decrease in blood TG levels [76,77]. The beneficial effect of hypoxic training on TG levels is explained by a higher rate of lipid oxidation due to increased expression of mRNA encoding peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) protein, which induces mitochondrial biogenesis and plays a key role in regulating fatty acid oxidation in muscles [76,78,79].…”

Section: Discussionmentioning

confidence: 99%

Exposure to Normobaric Hypoxia Combined with a Mixed Diet Contributes to Improvement in Lipid Profile in Trained Cyclists

et al. 2021

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This study aimed to analyze the effects of live high-train low method (LH-TL) and intermittent hypoxic training (IHT) with a controlled mixed diet on lipid profile in cyclists. Thirty trained male cyclists at a national level with at least six years of training experience participated in the study. The LH-TL group was exposed to hypoxia (FiO2 = 16.5%) for 11–12 h a day and trained under normoxia for 3 weeks. In the IHT group, participants followed the IHT routine three times a week under hypoxia (FiO2 = 16.5%) at lactate threshold intensity. The control group (N) lived and trained under normoxia. The results showed that the 3-week LH-TL method significantly improved all lipid profile variables. The LH-TL group showed a significant increase in HDL-C by 9.0% and a decrease in total cholesterol (TC) by 9.2%, LDL-C by 18.2%, and triglycerides (TG) by 27.6%. There were no significant changes in lipid profiles in the IHT and N groups. ∆TG and ∆TC were significantly higher in the LH-TL group compared to the N group. In conclusion, hypoxic conditions combined with a mixed diet can induce beneficial changes in lipid profile even in highly trained athletes. The effectiveness of the hypoxic stimulus is closely related to the hypoxic training method.

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Effects of Active and Passive Hypoxic Conditioning for 6 Weeks at Different Altitudes on Blood Lipids, Leptin, and Weight in Rats

Cited by 5 publications

References 34 publications

BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats

BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats

Intermittent Hypoxic-Hyperoxic Exposures Effects in Patients with Metabolic Syndrome: Correction of Cardiovascular and Metabolic Profile

Exposure to Normobaric Hypoxia Combined with a Mixed Diet Contributes to Improvement in Lipid Profile in Trained Cyclists

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