BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats

Feng, Junpeng; Wang, Xuebing; Lu, Yingli; Yu, Chang; Wang, Xinyan; Feng, Lianshi

doi:10.3389/fphys.2022.882151

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…It has been well-established that cold-exposure can induce BAT activation and AT browning in rats and humans [22,[41][42][44][45], which is consistent with the anticipated findings regarding the coldwater (15 o C) protocol. Moreover, hypoxic exercises have also been shown to induce BAT activation and AT in rats [29][30][31], particularly in the inguinal area [28,66], which is consistent with the anticipated findings for the hypoxia protocol, as proof of principle. The anticipated result for the hypoxic protocol is also consistent with the hypothesis by Mu et al, which highlighted the relationship of hypoxic exercise with better AT browning capabilities due to its ability to upregulate irisin and leptin levels [28].…”

Section: Discussionsupporting

confidence: 82%

Assessing the Induced Adipose Tissue Browning Effects of Hypoxic Swimming and Cold-Water Exposure in Healthy Human Participants Using Contrast-Enhanced Ultrasound (CEUS)

Sales

2024

URNCST Journal

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Introduction:The prevalence of obesity in Canada has increased in recent years. Due to this, studies have been conducted on brown adipose tissue (BAT) as it consumes energy to regulate thermal homeostasis rather than storing it as fat. Particularly, studies have shown that exercise regimens combined with a cold-temperature setting elicit the most "browning" of white adipose tissue (WAT). Hypoxic exercise has been seen to prevent obesity and some metabolic disorders, but the browning of WAT via hypoxic exercise has yet to be studied. Thus, this study aims to determine the independent and synergistic effects of cold-water exposure and hypoxic exercise BAT activation and adipose tissue browning in healthy adult males. Methods: Moderately active healthy adult males will be randomized in three experimental groups (i.e., Cold-water exposure group (CG), Hypoxic exercise group (HG), and combined cold-water and hypoxic exercise group (HC)) and one control group. Familiarization sessions will be done prior to the three testing sessions. Cold conditions will be induced via exercise in 15 o C water. Hypoxic conditions will be induced via the endogenous-hypoxic breathing technique. Contrast-Enhanced Ultrasound (CEUS) scans of regions of interest (i.e., supraclavicular, axilla, anterior abdominal wall, and the inguinal fossa) will be obtained before and after familiarization and testing sessions and will be further utilized for analysis. Results: It is anticipated that all experimental groups will demonstrate BAT activation and adipose tissue browning as reflected by the Acoustic Intensity (AI) curve and color-flow doppler intensity. Particularly, more pronounced in the supraclavicular region for CG, inguinal fossa for HG, and both for HC. Discussion: This research protocol anticipates evidence that suggests independent cases of BAT activation and adipose tissue browning, reflected in the CG and HG. This protocol also anticipates synergistic effects of cold water and hypoxic exercise in inducing BAT activation and adipose tissue browning, reflected by HC. Conclusion: Thus, hypoxia and cold-water interventions may have potential clinical use for managing the rising cases of obesity. Future implications may include public health initiatives that inform the population on ways to mitigate the effects of obesity and provide a potential therapeutic avenue to treat the disease.

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Section: Discussionsupporting

confidence: 82%

Assessing the Induced Adipose Tissue Browning Effects of Hypoxic Swimming and Cold-Water Exposure in Healthy Human Participants Using Contrast-Enhanced Ultrasound (CEUS)

Sales

2024

URNCST Journal

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“…A study including both normal and obese adolescents showed that serum BAIBA levels increased after prolonged exercise (aerobic or resistance) regardless of obesity ( 78 ). This was confirmed by the results of an animal model, in which four weeks of hypoxic training increased BAIBA levels in the gastrocnemius and blood of obese rats ( 79 ). Roberts et al.…”

Section: Exercise Regulates Baiba Synthesis and Metabolismsupporting

confidence: 56%

Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill

Yang

et al. 2023

Front. Endocrinol.

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Signaling metabolites can effectively regulate the biological functions of many tissues and organs. β-Aminoisobutyric acid (BAIBA), a product of valine and thymine catabolism in skeletal muscle, has been reported to participate in the regulation of lipid, glucose, and bone metabolism, as well as in inflammation and oxidative stress. BAIBA is produced during exercise and is involved in the exercise response. No side effect has been observed in human and rat studies, suggesting that BAIBA can be developed as a pill that confers the benefits of exercise to subjects who, for some reason, are unable to do so. Further, BAIBA has been confirmed to participate in the diagnosis and prevention of diseases as an important biological marker of disease. The current review aimed to discuss the roles of BAIBA in multiple physiological processes and the possible pathways of its action, and assess the progress toward the development of BAIBA as an exercise mimic and biomarker with relevance to multiple disease states, in order to provide new ideas and strategies for basic research and disease prevention in related fields.

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“…It induces the expression of the uncoupling protein UCP1 (uncoupling protein 1) and activates the nuclear receptor peroxisome proliferator‐activated receptor‐α, which affect fat metabolism and may contribute to changes in adipose tissue function and fat storage, potentially affecting cardiometabolic pathophysiology. 45 …”

Section: Bcaa ‐Regulated Pathways and Cardiometabolic Diseasementioning

confidence: 99%

Circulating Branched Chain Amino Acids and Cardiometabolic Disease

Fine,

Wilkins,

Sawicki

2024

JAHA

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Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, and heart failure. In this review, we provide a detailed overview of BCAA metabolism, focus on molecular mechanisms linking disrupted BCAA homeostasis with cardiometabolic disease, summarize the evidence from observational and interventional studies investigating associations between circulating BCAAs and cardiometabolic disease, and offer valuable insights into the potential for BCAA manipulation as a novel therapeutic strategy for cardiometabolic disease.

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BAIBA Involves in Hypoxic Training Induced Browning of White Adipose Tissue in Obese Rats

Cited by 5 publications

References 42 publications

Assessing the Induced Adipose Tissue Browning Effects of Hypoxic Swimming and Cold-Water Exposure in Healthy Human Participants Using Contrast-Enhanced Ultrasound (CEUS)

Assessing the Induced Adipose Tissue Browning Effects of Hypoxic Swimming and Cold-Water Exposure in Healthy Human Participants Using Contrast-Enhanced Ultrasound (CEUS)

Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill

Circulating Branched Chain Amino Acids and Cardiometabolic Disease

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