Effects of ACTH and Cortisone on Certain Diseases and Physiologic Functions of the Skin: I. Effects of Acth*

Sulzberger, Marion B.; Sauer, Gordon C.; Herrmann, F.; Baer, Rudolf L.; Milberg, Irving L.

doi:10.1038/jid.1951.40

Cited by 48 publications

(8 citation statements)

References 10 publications

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“…In our series we did not observe any dissemination of the eruption, or other side-effects in the prednisolone treated group. This accords with other reports (Sulzberger et al, 1951;Gelfand, 1954;Appelman, 1955;Sauer, 1955;Elliott, 1964;Eaglstein et al, 1970;Pearce, 1973). These findings are in sharp contrast with those of Merselis et al (1964), who reported seventeen cases of disseminated herpes zoster in corticosteroid treated patients.…”

Section: Discussionsupporting

confidence: 92%

Do corticosteroids prevent post-herpetic neuralgia?

Keczkes

Basheer

1980

British Journal of Dermatology

152

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Forty otherwise healthy patients over 50 years of age with early, severe painful herpes zoster were randomly allocated to two groups for treatment. Twenty patients received prednisolone 40 mg daily with gradual reduction over a period of 4 weeks, whilst the other twenty patients received carbamazepine 100 mg four times daily. Thirteen of the twenty patients (65%) in the carbamazepine treated group developed post-herpetic neuralgia lasting up to 2 years, whilst only three of the twenty prednisolone treated patients (15%) had post-herpetic neuralgia lasting up to 6 months only. Thus the incidence and duration of post-herpetic neuralgia were considerably redudced in the prednisolone treated group. In neither group did disseminated zoster or other complications occur.

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Section: Discussionsupporting

confidence: 92%

Do corticosteroids prevent post-herpetic neuralgia?

Keczkes

Basheer

1980

British Journal of Dermatology

152

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“…The previous uncontrolled observations reporting the effect of ACTH on HZ (Sulzberger et al, 1951;Nickel, 1951;Sauer, 1955;Appelman, 1955) suggested that ACTH works through the release of peripheral adrenal hormones. The present results indicate that ACTH might have an inherent analgesic effect.…”

Section: Discussionmentioning

confidence: 97%

ACTH versus prednisone and placebo in herpes zoster treatment

Clemmensen

Andersen

1984

Clin Exp Dermatol

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Summary The effect of ACTH (Synacthen‐depot®) versus prednisone and placebo in the treatment of herpes zoster (HZ) was studied in a controlled clinical trial comprising 60 consecutive patients. The treatment groups were comparable regarding sex, age and pre‐entry symptom duration. The skin changes, patients' pain scores and the consumption of analgesics were monitored. Regarding objective symptoms and the development of postherpetic neuralgia there was no difference between the two treatment groups and placebo, while the ACTH group showed a decrease in pain score and consumption of analgesics during the first 4 days of the trial. Whether this finding will justify the application of ACTH in early HZ is arguable. Neither ACTH nor prednisone influenced the development of postherpetic neuralgia but this negative finding may be inaccurate due to the small number of patients in the three groups. Severe side‐effects did not occur.

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“…The delayed granulomatous skin response attribut able to sessile (cellular) antibodies is frequently depressed, although not completely inhibited (4). Patch tests in patients with contact dermatitis also are not affected, except in a very narrow range with high dilutions (5). As might be expected from the observation that adrenal corticoids reduce vas cular damage but do not interfere with circulating antibody, it would appear that the Shwartzman phenomenon is inhibited by these compounds (6).…”

Section: Cortisone Hydrocortisone and Corticotropin Therapy In Skinmentioning

confidence: 92%