Dermatology

Pillsbury, Donald M.; Shelley, Walter B.

doi:10.1146/annurev.me.05.020154.002051

Cited by 12 publications

(12 citation statements)

References 16 publications

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“…Scientists have been interested in microorganisms that colonize the skin since Antoni van Leuwenhoek's first microscopic observation in 1683. But, the field of human microbiota in dermatology research really began with Kligman in the 1950's using improved cell culture methods . In 2000, the Nobel laureate Joshua Lederberg suggested using the term ‘human microbiome’ to describe the collective genome of our indigenous microorganisms (microflora) colonizing the whole body …”

Section: History and Definitionsmentioning

confidence: 99%

Microbiome in healthy skin, update for dermatologists

Dréno

Araviiskaia

Berardesca

et al. 2016

Acad Dermatol Venereol

204

186

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The skin is a complex barrier organ made of a symbiotic relationship between microbial communities and host tissue via complex signals provided by the innate and the adaptive immune systems. It is constantly exposed to various endogenous and exogenous factors which impact this balanced system potentially leading to inflammatory skin conditions comprising infections, allergies or autoimmune diseases. Unlike the gut and stool microbiome which has been studied and described for many years, investigations on the skin or scalp microbiome only started recently. Researchers in microbiology and dermatology started using modern methods such as pyrosequencing assays of bacterial 16S rRNA genes to identify and characterize the different microorganisms present on the skin, to evaluate the bacterial diversity and their relative abundance and to understand how microbial diversity may contribute to skin health and dermatological conditions. This article aims to provide an overview on the knowledge about the skin microbiota, the microbiome and their importance in dermatology.

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Section: History and Definitionsmentioning

confidence: 99%

Microbiome in healthy skin, update for dermatologists

Dréno

Araviiskaia

Berardesca

et al. 2016

Acad Dermatol Venereol

204

186

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“…In 1683, Antoni van Leuwenhoek made the first microscopic observation of bacteria colonizing the surface of the human skin [1]. Joshua Lederberg first suggested the term microbiome in 2000, meaning the collective genome of commensal, symbiotic and pathological bacteria, archaea and eukaryote of the human body [2].…”

Section: Introductionmentioning

confidence: 99%

Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases

et al. 2021

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There is a growing quantity of evidence on how skin and gut microbiome composition impacts the course of various dermatological diseases. The strategies involving the modulation of bacterial composition are increasingly in the focus of research attention. The aim of the present review was to analyze the literature available in PubMed (MEDLINE) and EMBASE databases on the topic of microbiome modulation in skin diseases. The effects and possible mechanisms of action of probiotics, prebiotics and synbiotics in dermatological conditions including atopic dermatitis (AD), psoriasis, chronic ulcers, seborrheic dermatitis, burns and acne were analyzed. Due to the very limited number of studies available regarding the topic of microbiome modulation in all skin diseases except for AD, the authors decided to also include case reports and original studies concerning oral administration and topical application of the pro-, pre- and synbiotics in the final analysis. The evaluated studies mostly reported significant health benefits to the patients or show promising results in animal or ex vivo studies. However, due to a limited amount of research and unambiguous results, the topic of microbiome modulation as a therapeutic approach in skin diseases still warrants further investigation.

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“…The first grading system assessing acne on the trunk was developed by Pillsbury et al . in 1956 40 . Burke et al 41 .…”

Section: Resultsmentioning

confidence: 99%

Truncal acne, what do we know?

Poli¹,

Auffret²,

Leccia

et al. 2020

Acad Dermatol Venereol

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Truncal acne is frequently overlooked in dermatological practice, even though it may result in scars and impact on self-esteem and body image. Therefore, it is important to identify the disease early in order to initiate treatment in time and, thus, to prevent it from worsening and resulting in physical and psychological sequelae. The aim of this review is to provide an overview of what is currently known about truncal acne, its prevalence, aetiology and physiopathology, how its severity is currently evaluated, how to differentiate it from other skin afflictions and current treatment options. A review of literature considering the issue of truncal acne published up to 2019 and available from PubMed was conducted, and in total, 76 articles were selected from PubMed. Currently, only little information about truncal acne is available. Considered as having the same pathophysiology as facial acne, the clinical picture and treatment response seem to differ. Specific acne severity grading systems and quality of life questionnaires as well as a specific treatment algorithm are still lacking. Filling this gap should allow clinicians to assess truncal acne in the best possible way, choosing suitable treatment options, helping patients to improve treatment adherence and quality of life and finally allowing a better management of truncal acne. In conclusion, more knowledge is required to treat more efficiently truncal acne.

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Dermatology

Cited by 12 publications

References 16 publications

Microbiome in healthy skin, update for dermatologists

Microbiome in healthy skin, update for dermatologists

Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases

Truncal acne, what do we know?

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