Effects of a Superpotent Melanotropic Peptide in Combination With Solar UV Radiation on Tanning of the Skin in Human Volunteers

Dorr, Robert T.; Ertl, Gregory; Levine, Norman; Brooks, Carla; Bangert, Jerry L.; Powell, Marianne Broome; Humphrey, S.M.; Alberts, David S.

doi:10.1001/archderm.140.7.827

Cited by 51 publications

(35 citation statements)

References 28 publications

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“…Although the exact role for ␣-MSH in melanoma cell migration remains unclear, our findings suggest that regulation syndecan-2 expression by ␣-MSH plays a crucial role in the migration of melanoma cells. Recent clinical studies have shown that a potent synthetic analogue of ␣-MSH, NDP-MSH, significantly increases the eumelanin content of human skin (42). Interestingly, ␣-MSHmediated syndecan-2 expression occurs independently of melanin synthesis (Fig.…”

Section: Discussionmentioning

confidence: 99%

Syndecan-2 Regulates the Migratory Potential of Melanoma Cells

Lee

Park

Chung

et al. 2009

Journal of Biological Chemistry

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Syndecan-2, a transmembrane heparan sulfate proteoglycan, is a critical mediator in the tumorigenesis of colon carcinoma cells. We explored the function of syndecan-2 in melanoma, one of the most invasive types of cancers, and found that the expression of this protein was elevated in tissue samples from both nevus and malignant human melanomas but not in melanocytes of the normal human skin tissues. Similarly, elevated syndecan-2 expression was observed in various melanoma cell lines. Overexpression of syndecan-2 enhanced migration and invasion of melanoma cells, whereas the opposite was observed when syndecan-2 levels were knocked down using small inhibitory RNAs. Syndecan-2 expression was enhanced by fibroblast growth factor-2, which is known to stimulate melanoma cell migration; however, ␣-melanocyte-stimulating hormone decreased syndecan-2 expression and melanoma cell migration and invasion in a melanin synthesis-independent manner. Furthermore, syndecan-2 overexpression rescued the migration defects induced by ␣-melanocyte-stimulating hormone treatment. Together, these data strongly suggest that syndecan-2 plays a crucial role in the migratory potential of melanoma cells.

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Section: Discussionmentioning

confidence: 99%

Syndecan-2 Regulates the Migratory Potential of Melanoma Cells

Lee

Park

Chung

et al. 2009

Journal of Biological Chemistry

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“…However, we believe that such a combined antiinflammatory and antifibrogenic activity of MSH peptides in the treatment of scleroderma would be welcome. Human toxicity studies in which 0.08 mg/kg of NDP-␣-MSH was given subcutaneously revealed only minor side effects (e.g., nausea and transient facial flushing) (45). Indeed, hyperpigmentation is a known effect of ␣-MSH and related peptides (46).…”

Section: Discussionmentioning

confidence: 99%

α‐melanocyte–stimulating hormone suppresses bleomycin‐induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?

Kokot¹,

Sindrilaru²,

Sunderkötter³

et al. 2009

Arthritis & Rheumatism

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HO-1). In the BLM mouse model, ␣-MSH reduced skin fibrosis and collagen content and increased tissue levels of SOD2 and HO-1. In skin and HDFs from patients with SSc, both MC-1R and POMC messenger RNAs were detected, but there were no differences compared with healthy controls.Conclusion. Alpha-melanocyte-stimulating hormone and related peptides that exert their effects via MC-1R may provide a novel antifibrogenic therapeutic tool for the treatment of fibrotic diseases such as scleroderma.Fibrotic diseases are a major challenge in medicine with regard to both pathogenesis and therapeutic intervention. The clinical spectrum of such disorders comprises many organs and includes localized and systemic scleroderma (SSc), idiopathic pulmonary fibrosis, Presented by Dr. Kokot in partial fulfillment of the requirements for a PhD degree,

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“…In the 1960s, Lerner and McGuire discovered that injections with αMSH, one of the MC1R agonists (see Figure 2), increased human skin pigmentation [77]. More recently, several studies examined the effects of [Nle 4 -D-Phe 7 ]-αMSH, a synthetic superpotent analogue of αMSH, on human skin in situ and reported increased pigmentation after a series of 10 injections [78][79][80][81]. In a larger study, injections of 65 subjects with a slow-release formulation of the same αMSH analogue over 3 months lead to an average 41% increase of melanin in subjects with high sun-sensitivity compared to a 12% increase in subjects with low sun-sensitivity, and there was no significant difference in pigmentation between sun-exposed and non-sun-exposed areas [82].…”

Section: Stimulation Of Melanogenesismentioning

confidence: 99%

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

Brenner

Hearing

2008

Drug Discovery Today: Disease Mechanisms

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Rates of skin cancer continue to increase despite the improved use of traditional sunscreens to minimize damage from ultraviolet radiation. The public perception of tanned skin as being healthy and desirable, combined with the rising demand for treatments to repair irregular skin pigmentation and the desire to increase or decrease constitutive skin pigmentation, arouses great interest pharmaceutically as well as cosmeceutically. This review discusses the intrinsic biochemistry of pigmentation, details mechanisms that lead to increased or decreased skin pigmentation, and summarizes established and potential hyper-and hypo-pigmenting agents and their modes of action.

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Effects of a Superpotent Melanotropic Peptide in Combination With Solar UV Radiation on Tanning of the Skin in Human Volunteers

Cited by 51 publications

References 28 publications

Syndecan-2 Regulates the Migratory Potential of Melanoma Cells

Syndecan-2 Regulates the Migratory Potential of Melanoma Cells

α‐melanocyte–stimulating hormone suppresses bleomycin‐induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: Melanocortin peptides as a novel treatment strategy for scleroderma?

Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents

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