Effects of a Pre-workout Supplement on Lean Mass, Muscular Performance, Subjective Workout Experience and Biomarkers of Safety

Abstract

In this prospective, randomized, double-blind, trial conducted in two parts, we examined the effects of a multi-ingredient pre-exercise workout supplement blend of creatine, betaine and a dendrobium extract (MMP) on safety, performance, and body composition in healthy men and women undergoing a supervised program of resistance exercise. Part 1 was an acute hemodynamic safety study wherein forty young, healthy men and women (26.2 ± 5.3 years, 70.4 ± 3.3 inches, 83.7 ± 14.9 kg, 26.0 ± 3.2 kg●m-2) ingest one dose of either the MMP or comparator in a randomized, double-blind, comparator controlled, crossover fashion before having their resting heart rate, blood, ECG and comprehensive blood chemistry and blood counts completed. Systolic (SBP) and diastolic (DBP) blood pressures were generally raised (3.0-5.4 mm Hg, p<0.01) following supplementation with MPP whereas in the comparator group SBP was marginally reduced by 0.3 to 1.2 mm Hg, p>0.05 at all time points) and DBP was increased (3.0 - 3.9 mm Hg, p<0.05 at all time points). No changes in EKG-corrected QT interval were observed, and no serious adverse events were reported. Part 2 was a six-week training study wherein forty-three young, healthy men and women (24.3 ± 2.9 years, 70.5 ± 3.1 inches, 83.8 ± 9.6 kg, 26.1 ± 2.7 kg●m-2) supplemented with daily pre-workout doses of either the MPP or a comparator in a randomized, double-blind, comparator-controlled fashion while following a standardized resistance training program for six weeks. MPP and the comparator were isocaloric and delivered the same amount of caffeine. Significant improvements in visual analog scale (VAS) scores for energy (p<0.024) and concentration (p<0.041) were found along with consistently higher levels of focus accompanied by less fatigue when MPP was consumed in comparison to comparator during upper body muscular strength-endurance tests at weeks 3 and 6. MPP supplementation for 6 weeks did not improve dual-energy x-ray absorptiometry (DEXA) measures of body composition or objective assessments of exercise performance. Overall, MPP use and administration was well tolerated. Self-reported scores for energy and concentration were significantly greater. Over a six-week training and supplementation period, MPP use was not associated with improvements in performance or body composition. Future studies should confirm these effects over a more prolonged training period.

Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males

“…4). However, consistent with findings from Outlaw and colleagues [58], we did not observe a significant improvement in body composition changes in response to training as has previously been reported [56, 69]. This includes when adding 20 mg of synephrine (as Citrus Aurantium) to the formulation.…”

“…2) indicated that change in Stroop Color and Word-Color counts were significantly above baseline in the PWS group and changes in Word count, Color count, and Word-Color counts were greater in the PWS + S group after 4-weeks of training and these changes were generally greater than the placebo group. These findings are consistent with several studies that reported that acute or chronic ingestion of PWS formulations containing caffeine positively affected cognitive function, concentration, and/or perceptions of energy [5, 56, 57]. The Stroop Color-Word test assesses attention, processing speed, and executive function which have been shown to decline as one fatigues.…”

“…In this regard, we observed no significant changes in resting hemodynamics, clinical blood markers, or a disproportional number of reported side effects in the PWS groups. These findings are consistent with a growing body of evidence that PWS supplementation appears to be safe and well-tolerated in apparently healthy individuals [56–59, 69, 70, 72–78] and that combination of these types of nutrients in PWS does not pose undue risk.…”

Effect of a Multi-Nutrient Over-the-Counter Supplement on Changes in Metabolic Rate and Markers of Lipolysis

“…Other common ingredients include green tea extract, capsaicin and most recently raspberry ketones. Research is especially sparse with raspberry ketones with most data available coming from animal or cell culture models (Park, 2010;Morimoto et al, 2005), but recent work by Lopez (Lopez et al, 2013) and Kedia (Kedia et al, 2014) have shown positive impacts of differing multi-ingredient thermogenic supplement formulations in humans that included raspberry ketones along with other ingredients. Similar to caffeine, studies are available that have examined the sole impact of green tea extract or various catechins found in green tea on stimulating increased rates of fat oxidation and metabolic rate (Dulloo et al, 2000;Dulloo et al, 1999).…”

Efeitos da cafeína na performance de exercícios de endurance

“…Os resultados demonstraram que não houve melhorias no desempenho e na composição corporal; contudo, houve melhoria significativa na sensação subjetiva de esforço (p<0,024) e na concentração (p<0,041), gerando níveis mais elevados de foco no exercício. 12 Todavia, pesquisa 13 utilizou a mesma quantidade de cafeína do estudo anterior em atletas de esportes coletivos, os quais verificaram melhora na capacidade de realização de sprints repetidos, que de acordo com Spencer e colaboradores, 14 é uma boa indicativa no desempenho em modalidades coletivas. Estes fatos relacionados à melhora da motivação e diminuição da sensação subjetiva de esforço também foram relatados em outro estudo.…”