Effects of a porphyrazine derivative on some developmental characteristics ofDrosophila melanogaster

Abstract

In this study, the effects of a porphyrazine derivative, [octakis (2-trimethylammoniumethyl thio) porphyrazinatocobalt] octaiodide (CoPzq), were explored on the developmental characteristics, sex ratio and egg fertility of Drosophila melanogaster. CoPzq was preferred in the study due to its probability to be used as a chemotherapeutic agent in medicine. As a result of the application of CoPzq, a phenotypic abnormality was revealed within the individuals of F1 and F2 generation of Drosophila. Although individuals of F2 generation did not directly come into contact with the chemical, the rate of abnormality is high. An increase was observed within both generations in terms of the egg fertility. Besides, a deviation emerged in the sex-ratio in some concentrations.

Dairy Products Added in Media Affect the Development of Drosophila melanogaster (Diptera: Drosophilidae)

“…The results of the present study showed that kefir, yogurt, and milk reduced the number of adults in Drosophila , thereby impeding development. The observation of a decrease in the number of adults in Drosophila is usually a result of the application of toxic substances ( Karataş and Bahçeci 2009a , Karataş et al 2011a , Karataş et al 2011b , Keser and Karataş 2012 ). Hence, it was unexpected that foods that are nutritious and beneficial for humans had such negative effects on Drosophila that they could be considered toxic.…”

“…It can be concluded that the substances added to the medium do not increase the rate of these mutations. However, in toxic drug applications to Drosophila , these mutations increase and the rate of abnormal phenotypes also increases ( Karataş and Bahçeci 2009b , Karataş and Bahçeci 2010 , Karataş et al 2011a , Karataş et al 2012 ). Hence, it appears that kefir, yogurt, and milk negatively affect development but do not increase the rate of mutation causing the increase in abnormal phenotypes.…”

“…To observe the effect of milk and fermented milk products on the sex ratio, after cross-breeding, males and females obtained from both generations were recorded separately. The data were evaluated to determine whether there was a change in the sex ratio ( Karataş and Bahçeci 2009b , Karataş et al 2011a ). An Olympus SZ61-dissecting microscope was used.…”

“…Thus, 10 females and 10 males randomly selected from the F 1 generation were transferred to the standard medium and cross-bred and the F 2 generation was obtained. The same process was carried out for the F 2 generation as for the F 1 generation during the observation phase ( Karataş et al 2011a ).…”