Effects of a Novel Magnesium Complex on Metabolic and Cognitive Functions and the Expression of Synapse-Associated Proteins in Rats Fed a High-Fat Diet

Orhan, Cemal; Tuzcu, Mehmet; Defo, Patrick Brice Deeh; Şahin, Nurhan; Ojalvo, Sara Perez; Sylla, Sarah; Komorowski, James; Şahin, Kazım

doi:10.1007/s12011-021-02619-z

Cited by 10 publications

(7 citation statements)

References 53 publications

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“…Picolinic acid, which has a highly chelating capacity, improves Mg bioavailability in synthetic MgPic form [ 25 ]. Recently, Orhan et al [ 26 ] reported that MgPic increased Mg bioavailability as well as serum and liver Mg levels more than MgO in rats [ 26 ]. Similarly, our study showed that BMD levels increased in parallel with bone Mg levels in rats after MgPic supplementation.…”

Section: Discussionmentioning

confidence: 99%

“…Although MgPic contains 9% elemental Mg, it may show higher bioavailability than other Mg forms, such as MgO [ 25 ]. Previous studies have demonstrated that MgPic, rather than MgO, had more anti-inflammatory and antioxidant effects in the brain [ 26 ] and retina in rats [ 27 ]. The effects of different forms of magnesium (MgPic vs. MgO) on the RANK/RANKL/OPG and BMP-2/Runx2 signaling pathways associated with bone mineral density have not yet been fully investigated in rats fed with HFD.…”

Section: Introductionmentioning

confidence: 99%

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Magnesium Picolinate Improves Bone Formation by Regulation of RANK/RANKL/OPG and BMP-2/Runx2 Signaling Pathways in High-Fat Fed Rats

et al. 2021

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Magnesium (Mg) deficiency may affect bone metabolism by increasing osteoclasts, decreasing osteoblasts, promoting inflammation/oxidative stress, and result in subsequent bone loss. The objective of the present study was to identify the molecular mechanism underlying the bone protective effect of different forms of Mg (inorganic magnesium oxide (MgO) versus organic magnesium picolinate (MgPic) compound) in rats fed with a high-fat diet (HFD). Forty-two Wistar albino male rats were divided into six group (n = 7): (i) control, (ii) MgO, (iii) MgPic, (iv) HFD, (v) HFD + MgO, and (vi) HFD + MgPic. Bone mineral density (BMD) increased in the Mg supplemented groups, especially MgPic, as compared with the HFD group (p < 0.001). As compared with the HFD + MgO group, the HFD + MgPic group had higher bone P (p < 0.05) and Mg levels (p < 0.001). In addition, as compared to MgO, MgPic improved bone formation by increasing the levels of osteogenetic proteins (COL1A1 (p < 0.001), BMP2 (p < 0.001), Runx2 (p < 0.001), OPG (p < 0.05), and OCN (p < 0.001), IGF-1 (p < 0.001)), while prevented bone resorption by reducing the levels of RANK and RANKL (p < 0.001). In conclusion, the present data showed that the MgPic could increase osteogenic protein levels in bone more effectively than MgO, prevent bone loss, and contribute to bone formation in HFD rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnesium Picolinate Improves Bone Formation by Regulation of RANK/RANKL/OPG and BMP-2/Runx2 Signaling Pathways in High-Fat Fed Rats

et al. 2021

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“…Tissues were homogenized according to the previous method ( Orhan et al, 2021 ) to determine the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels. Based on the manufacturer’s procedure, the SOD, CAT, and GSH-Px activities were measured using ELISA kits (Cayman Chemical, Ann Arbor, MI, USA).…”

Section: Methodsmentioning

confidence: 99%

Effects of magnesium picolinate, zinc picolinate, and selenomethionine co-supplementation on reproductive hormones, and glucose and lipid metabolism-related protein expressions in male rats fed a high-fat diet

Şahin

Orhan

Küçük

et al. 2022

Food Chemistry: Molecular Sciences

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“…Magnesium exerts an anti-inflammatory activity through the regulation of the NF-kB/Nrf2 signaling pathways. 87 Magnesium supplementation was able to improve memory and learning in patients affected by dementia and in healthy animals and was shown to play a key role in neuronal maturation. 88 The relationship between magnesium concentration in the serum and mental health has been highlighted in a crosssectional study that showed an association between low magnesium concentration in the serum and greater perceived stress in healthy women without psychiatric disorders.…”

Section: The Magnesium Role In Mental Health and Well-beingmentioning

confidence: 99%

Food supplements to complement brain functioning: the benefits of a combination of magnesium, folic acid, omega-3 fatty acids and vitamin E

Businaro

2022

F1000Res

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Diet and nutrition play a fundamental role not only in human body composition and in physiology, but have also relevant effects on mood, mental well-being and cognitive performance. In particular, the preservation of mental well-being through a healthy lifestyle, including a well-balanced diet and, in case, through the intake of specific food supplements, is of particular relevance in the perspective of global human ageing, as the brain is affected significantly by a persistent presence of stress factors. Due to the increasing burden of mental and neurological disorders and to the universality of food as a modifiable risk factor, even limited improvements in nutritional habits may translate to a considerable rise of well-being and mental health in the global population. Moreover, the use of targeted, well-balanced food supplements aiming to support the mental health and well-being will probably represent a relevant tool in future decades, together with an increased awareness of the importance of nutrition, also considering the COVID-19 pandemic and the related stressful events and limitations we are still experiencing at global level. The aim of this review is to summarize the experimental and clinical data reported in the literature concerning the beneficial effects of a subset of micro- and macronutrients contained both in food and in supplements, namely magnesium, folic acid, docosahexaenoic acid, eicosapentaenoic acid, and alpha-tocopherol, on a series of disorders, including stress, anxiety, low sleep quality, and low cognitive performance.

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Effects of a Novel Magnesium Complex on Metabolic and Cognitive Functions and the Expression of Synapse-Associated Proteins in Rats Fed a High-Fat Diet

Cited by 10 publications

References 53 publications

Magnesium Picolinate Improves Bone Formation by Regulation of RANK/RANKL/OPG and BMP-2/Runx2 Signaling Pathways in High-Fat Fed Rats

Magnesium Picolinate Improves Bone Formation by Regulation of RANK/RANKL/OPG and BMP-2/Runx2 Signaling Pathways in High-Fat Fed Rats

Effects of magnesium picolinate, zinc picolinate, and selenomethionine co-supplementation on reproductive hormones, and glucose and lipid metabolism-related protein expressions in male rats fed a high-fat diet

Food supplements to complement brain functioning: the benefits of a combination of magnesium, folic acid, omega-3 fatty acids and vitamin E

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