Effects of a multimodal exercise protocol on functional outcomes, epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults: a quasi-experimental pilot study

Fraga, Iasmin; Weber, Camila; Galiano, Wériton Baldo; Iraci, Lucio; Wohlgemuth, Mariana; Morales, Gabriela; Cercato, Camila; Rodriguez, Juliana Dalla Martha; Pochmann, Daniela; Dani, Caroline; Menz, Pérsia; Bosco, Adriane Dal; Elsner, Viviane Rostirola

doi:10.4103/1673-5374.313067

Cited by 10 publications

(4 citation statements)

References 60 publications

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“…In general, physical exercise is involved in the balance regulation of neurotransmitters [5]. It can improve cognitive and autonomic system functions [6,7] by influencing the concentration of circulating epinephrine and norepinephrine [8] and through modulating the expression of some neurotrophic factors (such as the brain-derived neurotrophic factor (BDNF)), even in pathological conditions [9,10]. Indeed, the BDNF factor is involved in the amplification of the neuroendocrine response, which in turn acts on the growth, survival and maintenance of neurons, both during development and in the adult brain [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach

et al. 2021

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Physical activity could play a key role in improving the quality of life, particularly in patients with nervous system diseases such as multiple sclerosis (MS). Through lactacid anaerobic training, this study aims to investigate the effects at a bio-psycho-physical level to counteract the chronic fatigue associated with the pathology, and to improve mental health at a psychological and neurotrophic level. Eight subjects (age: 34.88 ± 4.45 years) affected by multiple sclerosis were involved. A lactate threshold training program was administered biweekly for 12 weeks at the beginning of the study (T0), at the end of the study (T1) and at 9 months after the end of the study (T2), with physical, psychological and hematochemicals parameters, and dietary habits being tested. The results obtained confirmed that lactacid exercise can influence brain-derived neurotrophic factor (BDNF) levels as well as dehydroepiandrosterone sulfate (DHEAS) levels. In addition, levels of baseline lactate, which could be best used as an energy substrate, showed a decrease after the protocol training. Self-efficacy regarding worries and concerns management significantly increased from T0 to T1. The eating attitudes test (EAT-26) did not highlight any eating disease in the patients with a normal diet enrolled in our study. Physical exercise also greatly influenced the patients psychologically and emotionally, increasing their self-esteem. Lactate threshold training, together with dietary habits, appears to exert synergic positive effects on inflammation, neural plasticity and neuroprotection, producing preventive effects on MS symptoms and progression.

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Section: Introductionmentioning

confidence: 99%

Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach

et al. 2021

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“…According to findings of present study, RT increased BDNF and TrKB and decreased corticosterone and this can be associated with increasing memory. Previous studies have indicated that RT can possibly increase memory through increase the expression growth factors (BDNF and TrKB) (90,91), neurogenesis (92), serotonin expression and inhibition of apoptosis (28) and reducing corticosterone (87). The results of this study showed that through possible mentioned mechanisms, exercise after both stress and non-stress conditions improved memory, although this effect was significantly greater in non-stress conditions.…”

Section: Discussionmentioning

confidence: 51%

Effect of Running Training on Growth Factors and Astrogliosis and Cell Injury of the Hippocampus in Stressed Rats

Safari

Jahromi

Hadi

et al. 2023

Preprint

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The aim of this study was evaluating the effect of running training (RT) on brain-derived neurotrophic factor (BDNF) and its receptor TrKB, glial fibrillary acidic protein (GFAP), dark neurons and thickness of CA1 and dentate gyrus (DG), corticosterone and spatial memory performance in adult male rats exposed to chronic stress. Adult male wistar rats were randomly assigned to five groups: RT; exposure to chronic mild stress (CS); exposure to chronic mild stress followed by running training, (CS + RT), (CS + Recovery); control group. Findings indicated that the lowest expression of GFAP, number of dark neurons and corticosterone level, the highest thickness of CA1, DG, BDNF and TrKB and spatial memory performance were observed in the RT group. In the CS + RT group, expression of GFAP, the number of dark neurons and corticosterone level were lower, while thickness of CA1 and DG, BDNF, TrKB and spatial memory performance were higher compared to control and CS + Recovery. In the CS group, the expression of GFAP, the number of dark neurons and corticosterone level were highest and thickness of CA1 and DG, BDNF, TrKB and spatial memory performance were lowest among the study groups. In the CS + Recovery group, the expression of GFAP, the number of dark neurons and corticosterone level were lower, compared to the CS group. The study revealed that running training could attenuate the expression of GFAP, the number of dark neurons, corticosterone level and improve stress-induced reduction of BDNF, TrKB and spatial memory.

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“…Further evidence for the potential role of endothelial cells of the microvasculature in postmenopausal conditions can be derived from studies indicating that exercise can prevent or alleviate the progression of bone loss and conditions such as osteoporosis [181][182][183][184], can prevent the loss of cardiovascular integrity [185][186][187][188], osteoarthritis [189], and dementia [190][191][192][193], as well as the prevention of aging-related endothelial cell senescence [194][195][196][197]. In contrast, physical inactivity can contribute to brain-associated changes and such changes are mediated in part by epigenetic alterations [198].…”

Section: What Cells May Be Involved In the Relevant Epigenetic Modifi...mentioning

confidence: 99%

The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?

Hart

2024

IJMS

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For much of human evolution, the average lifespan was <40 years, due in part to disease, infant mortality, predators, food insecurity, and, for females, complications of childbirth. Thus, for much of evolution, many females did not reach the age of menopause (45–50 years of age) and it is mainly in the past several hundred years that the lifespan has been extended to >75 years, primarily due to public health advances, medical interventions, antibiotics, and nutrition. Therefore, the underlying biological mechanisms responsible for disease risk following menopause must have evolved during the complex processes leading to Homo sapiens to serve functions in the pre-menopausal state. Furthermore, as a primary function for the survival of the species is effective reproduction, it is likely that most of the advantages of having such post-menopausal risks relate to reproduction and the ability to address environmental stresses. This opinion/perspective will be discussed in the context of how such post-menopausal risks could enhance reproduction, with improved survival of offspring, and perhaps why such risks are preserved. Not all post-menopausal females exhibit risk for this set of diseases, and those who do develop such diseases do not have all of the conditions. The diseases of the post-menopausal state do not operate as a unified complex, but as independent variables, with the potential for some overlap. The how and why there would be such heterogeneity if the risk factors serve essential functions during the reproductive years is also discussed and the concept of sets of reversible epigenetic changes associated with puberty, pregnancy, and lactation is offered to explain the observations regarding the distribution of post-menopausal conditions and their potential roles in reproduction. While the involvement of an epigenetic system with a dynamic “modification-demodification-remodification” paradigm contributing to disease risk is a hypothesis at this point, validation of it could lead to a better understanding of post-menopausal disease risk in the context of reproduction with commonalities may also lead to future improved interventions to control such risk after menopause.

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Effects of a multimodal exercise protocol on functional outcomes, epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults: a quasi-experimental pilot study

Cited by 10 publications

References 60 publications

Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach

Lactate Threshold Training Program on Patients with Multiple Sclerosis: A Multidisciplinary Approach

Effect of Running Training on Growth Factors and Astrogliosis and Cell Injury of the Hippocampus in Stressed Rats

The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?

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