Effects of a multicomponent exercise program combined with calcium–vitamin D3-enriched milk on health-related quality of life and depressive symptoms in older men: secondary analysis of a randomized controlled trial

Matthews, Joshua; Torres, Susan; Milte, Catherine M.; Hopkins, Indee; Kukuljan, Sonja; Nowson, Caryl; Daly, Robin M.

doi:10.1007/s00394-019-01969-8

Cited by 12 publications

(10 citation statements)

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“…We identified 2 instances of records reporting on the same https://doi.org/10.11005/jbm.2021.28.1.27 study cohort, but different outcomes. [24][25][26][27][28] In these instances, we collated the data so that each intervention was the unit of interest, rather than each record. We searched PubMed on July 24, 2020 but did not locate errata or retractions for included studies.…”

Section: Resultsmentioning

confidence: 99%

“…We did not locate RCTs of physical activity interventions that reported fracture as a major outcome, importantly from a person-centered perspective only one study reporting QOL, and there were relatively few studies (and with small sample sizes and relatively short duration), and adverse events were inconsistently reported without information for how these events were adjudicated. We further underscore limited evidence (2 included studies) [24][25][26][27][28] that used 3-dimensional (3D) imaging to assess changes in bone outcomes. Given that imaging has advanced in rehttps://doi.org/10.11005/jbm.2021.28.1.27 cent years, it is important for future interventions to use instruments that can provide better characterization of bone structure and strength.…”

Section: Discussionmentioning

confidence: 99%

“…There were also significant localized changes at the proximal femur on the leg that completed the exercises. For the study by Kukuljan and colleagues [26,27] and Matthews and colleagues [28] participants in the exercise group increased aBMD at the femoral neck at 12 months (Fig. 2), increased femoral neck cross-sectional area and bone strength (section modulus), and increased lumbar spine aBMD at 12 months (Fig.…”

Section: Summary Of Findings From Studies Not Included In Meta-analysismentioning

confidence: 95%

“…Two studies compared different types of interventions (Table 2). [29,32] No included studies had fracture as their primary outcome but fracture was included as an adverse event; 1 study [28] included health-related QOL outcomes and reported no differences after 12 months between exercise (progressive resistance training and impact weight-bearing) and control groups. All included studies assessed bone using dual energy X-ray absorptiometry (DXA; aBMD).…”

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Physical Activity and Bone Health in Men: A Systematic Review and Meta-Analysis

et al. 2021

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Background Research on osteoporosis and physical activity often focuses on women. We aimed to conduct a systematic review to assess the benefits and harms of physical activity interventions for men’s bone health. Methods We used standard methods and searched for randomized controlled trials (RCTs) (duration, ≥6 months) published in all languages across multiple databases and trial registries. The last search was conducted on July 22, 2020. Results We included 11 studies (14 publications), resulting in a sample of N=723 men (range, 17–132 participants). We found low-certainty evidence that physical activity has little influence on the areal bone mineral density (aBMD) at the total hip (5 RCTs, N=324; mean difference [MD], 0.03 [95 confidence interval (CI), 0.01 to 0.05]) and little or no influence on the aBMD at the femoral neck (3 RCTs, N=186; MD, 0.00 [95% CI, −0.04 to 0.04]), lumbar spine (3 RCTs; N=213; MD, 0.05 [95% CI, −0.01 to 0.11]), and whole body (4 RCTs, N=203; MD, −0.00 [95% CI, −0.03 to 0.02]). Conclusions We found low-certainty evidence that physical activity (≥6 months) has some effect on the total hip in men, but new evidence may change this finding. This review highlights the gap in the evidence on specific intervention prescriptions that can benefit the bone geometry, structure, microarchitecture, and, ultimately, bone strength in men. Future research should engage in comprehensive reporting of harms, quality of life outcomes, advanced imaging findings, and long-term interventions.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Summary Of Findings From Studies Not Included In Meta-analysismentioning

confidence: 95%

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Physical Activity and Bone Health in Men: A Systematic Review and Meta-Analysis

et al. 2021

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“…Costan et al also reported that vitamin D-fortified bread can improve quality of life in nursing home residents with vitamin D deficiency (Costan et al, 2014). In contrast, Matthews et al observed no significant improvement in quality of life or depression symptoms following administration of vitamin D-fortified milk (Matthews et al, 2019). The reasons for these controversial results may be due to differences in the health status of subjects, study duration, and vitamin D received as intervention.…”

Section: Ta B L E 1 Baseline Features Of Study Populationmentioning

confidence: 99%

Efficacy of low‐fat milk and yogurt fortified with encapsulated vitamin D₃on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial

Sharifan

Khoshakhlagh

Khorasanchi

et al. 2020

Food Science & Nutrition

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Introduction Sleep disorders are a common condition globally. Vitamin D receptors are present on cells in several regions of the brain. It is possible that vitamin D status may affect brain function, including sleep patterns. We aimed to evaluate the 1,500 IU of Nano‐encapsulated vitamin D fortified in dairy products on the symptoms of insomnia and associated improvement of quality of life. Methods A case series was undertaken as part of the Survey of ultraviolent intake by nutritional approach project. Subjects enrolled among adults with abdominal obesity. Twenty‐nine subjects with insomnia were selected according to the results of Insomnia Severity Index questionnaire and quality of life using a Short Form Health Survey (SF‐36) questionnaire. Subjects were allocated to four groups: low‐fat milk fortified by 1,500 IU vitamin D3 (n = 8), simple milk (n = 8), low‐fat yogurt fortified by 1,500 IU vitamin D3 (n = 7), and simple yogurt (n = 6) and were treated for 10 weeks. Results The insomnia score improved after the intervention in the group receiving vitamin D fortified milk compared to group receiving unfortified milk (p < .001). There were no significant differences between the two groups taking yogurt (fortified vs. unfortified). Comparison of quality of life scores between baseline and after intervention indicated significant improvements in both fortified and simple milk groups (p = .002 and p = .03, respectively); but no differences were found in the groups taking yogurt. Conclusion Fortified low‐fat milk containing 1,500 IU vitamin D3 can improve insomnia symptoms and subsequently quality of life. Trial registration number: IRCT20101130005280N27, http://www.IRCT.ir.

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Effects of an 18-month community-based, multifaceted, exercise program on patient-reported outcomes in older adults at risk of fracture: secondary analysis of a randomised controlled trial

et al. 2023

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Summary This study identified that an 18-month community-based, multifaceted, exercise program consisting of resistance, weight-bearing impact, and balance/mobility training combined with osteoporosis education and behavioural support can improve health-related quality of life (HRQoL) and osteoporosis knowledge in older adults at risk of fracture, but only for those adherent to the exercise regime. Purpose To evaluate the effects of an 18-month community-based exercise, osteoporosis education and behaviour change program ( Osteo-cise: Strong Bones for Life ) on HRQoL, osteoporosis knowledge and osteoporosis health beliefs. Methods This was a secondary analysis of an 18-month randomised controlled trial in which 162 older adults aged ≥ 60 years with osteopenia or increased falls/fracture risk were randomized to the Osteo-cise program ( n = 81) or control group ( n = 81). The program consisted of progressive resistance, weight-bearing impact and balance training (3 days/week); osteoporosis education to facilitate self-management of musculoskeletal health and behavioural support to enhance adherence to exercise. HRQoL, osteoporosis knowledge and osteoporosis health beliefs were assessed using the EuroQoL questionnaire (EQ-5D-3L), Osteoporosis Knowledge Assessment Tool and Osteoporosis Health Belief Scale, respectively. Results Overall, 148 participants (91%) completed the trial. Mean exercise adherence was 55% and mean attendance for the three osteoporosis educational sessions ranged from 63-82%. After 12 and 18 months, there were no significant effects of the Osteo-cise program on HRQoL, osteoporosis knowledge or health beliefs relative to controls. Per protocol analyses (≥ 66% exercise adherence; n = 41) revealed a significant net benefit in EQ-5D-3L utility for the Osteo-cise group relative to controls after 12 months ( P = 0.024) and 18 months ( P = 0.029) and a significant net improvement in osteoporosis knowledge scores at 18 months ( P = 0.014). Conclusion This study supports the importance of adherence to exercise regimes, as adherence to the Osteo-cise: Strong Bones for Life program was associated with improvements in HRQoL and osteoporosis knowledge in older adults at increased risk for falls and fractures. Trial registration number: ACTRN12609000100291. Supplementary Information The online version contains supplementary material available at 10.1007/s00198-023-06693-y.

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Effects of a multicomponent exercise program combined with calcium–vitamin D3-enriched milk on health-related quality of life and depressive symptoms in older men: secondary analysis of a randomized controlled trial

Cited by 12 publications

References 41 publications

Physical Activity and Bone Health in Men: A Systematic Review and Meta-Analysis

Physical Activity and Bone Health in Men: A Systematic Review and Meta-Analysis

Efficacy of low‐fat milk and yogurt fortified with encapsulated vitamin D₃on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial

Effects of an 18-month community-based, multifaceted, exercise program on patient-reported outcomes in older adults at risk of fracture: secondary analysis of a randomised controlled trial

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Effects of a multicomponent exercise program combined with calcium–vitamin D3-enriched milk on health-related quality of life and depressive symptoms in older men: secondary analysis of a randomized controlled trial

Cited by 12 publications

References 41 publications

Physical Activity and Bone Health in Men: A Systematic Review and Meta-Analysis

Physical Activity and Bone Health in Men: A Systematic Review and Meta-Analysis

Efficacy of low‐fat milk and yogurt fortified with encapsulated vitamin D3on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial

Effects of an 18-month community-based, multifaceted, exercise program on patient-reported outcomes in older adults at risk of fracture: secondary analysis of a randomised controlled trial

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Efficacy of low‐fat milk and yogurt fortified with encapsulated vitamin D₃on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial