Effects of a low power laser beam guided by optic fiber on rat brain striatal monoamines and amino acids

Shen-Zeng,; Xiaojian,; Lin, Songyi; Wang, Lihua

doi:10.1016/0304-3940(82)90275-0

Cited by 21 publications

(6 citation statements)

References 11 publications

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“…In addition, Leszkiewicz et al (2000) found in their patch-clamp study an enhanced N -methyl- d -aspartate (NMDA) receptor-mediated response in cortical neurons. Moreover, a wide variety of evidence exists for at least monochromatic light’s capability to trigger, for example, serotonin, dopamine, noradrenaline, and cytokines release (Shen-Zeng et al 1982; Cassone et al 1993). Finally, an excretion of corticosterone, as well as its clock gene activation, has been shown to be a response to monochromatic light (Rahman et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Encephalopsin (OPN3) protein abundance in the adult mouse brain

et al. 2012

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Encephalopsin belongs to the family of extraretinal opsins having a putative role in CNS tissue photosensitivity. Encephalopsin mRNA has earlier been localized in rodent brains, but expression and localization of the protein has not yet been reported. In this study, we aimed to define encephalopsin protein abundance and localization in the rodent brain. The distribution and localization of encephalopsin protein in a mouse brain and selected peripheral tissues were analysed in ten mice, using Western blotting and immunohistochemistry. The specificity of immunoreaction was validated by primary antibody omitting and immunizing peptide blocking experiment. We found encephalopsin protein abundant in the mouse brain, but not in the periphery. Encephalopsin protein was present in neurons of the mouse cerebral cortex, paraventricular area, and cerebellar cells. Our results show that encephalopsin is expressed at the protein level in different brain areas of the mouse. Therefore, the suggested idea that encephalopsin plays a role in non-visual photic processes seems to be applicable. Evidently, further investigations are needed to find out the signalling mechanisms, and the potential physiological role of encephalopsin in phototransduction due to the changes in ambient light.

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Section: Discussionmentioning

confidence: 99%

Encephalopsin (OPN3) protein abundance in the adult mouse brain

et al. 2012

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“…In our previous experiments, we found that laser radiation to the caudate nucleus caused changes both in striatal biochemistry [21] and in electrophysiology [22], but we could not observe any animal's spontaneous behavioral changes. In this paper we will present the effects of laser radiation to the caudate nucleus on learning behavior.…”

Section: Nt Ro Duct10 Nmentioning

confidence: 72%

Effects of laser guided by optic fiber into rat brain on conditioned avoidance response and brain chemistry

et al. 1983

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Low power lasers were guided by optic fibers into the rat caudate nucleus or frontal cortex, during conditioned avoidance response (CAR) training. The changes in striatal monoamine and amino acid concentrations were subsequently determined. Of six training groups tested, only the experimental group with helium-neon laser radiation to the caudate nucleus exhibited the formation of CAR and an increase of unconditioned leg contractions. The striatal concentrations of dopamine (DA) and norepinephrine (NE) were increased simultaneously in the group.

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“…The most reasonable hypothesis is that the low energy laser, which can penetrate only few millimeters of tissue 7 , is absorbed by chromophores specific to each wavelength, without an appreciable rise in overall tissue temperature. When these chromophores are enzymes 23 , organelles or cell membrane molecules, their activity is altered and, thus, the metabolism or membrane permeability to specific molecules are altered 4 . The action spectra required to prove that this is a photochemical phenomenon has been demonstrated for enzymes 13 .…”

Section: Discussionmentioning

confidence: 99%

Low Power Laser Irradiation Effect with Emphasis on Injured Neural Tissues.

Schwartz¹

1993

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Effects of a low power laser beam guided by optic fiber on rat brain striatal monoamines and amino acids

Cited by 21 publications

References 11 publications

Encephalopsin (OPN3) protein abundance in the adult mouse brain

Encephalopsin (OPN3) protein abundance in the adult mouse brain

Effects of laser guided by optic fiber into rat brain on conditioned avoidance response and brain chemistry

Low Power Laser Irradiation Effect with Emphasis on Injured Neural Tissues.

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