Effects of a long-term elemental diet on gastrointestinal microflora in rats.

Kakihara, Michiaki

doi:10.5833/jjgs.20.1076

Cited by 2 publications

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“…responsiveness to vitamin K therapy does not indicate liver dysfunction. Factors contributing to vitamin K deficiency include malnutrition, malabsorption owing to a chronic gastrointesitinal disorder, 6 suppression of intestinal bacterial flora owing to enteral nutrition 7,8 and antibiotics therapy, 9,10 and hepatic dysfunction. In severely disabled children fed by means of enteral nutrition, there are many factors influencing vitamin K deficiency in their daily life.…”

Section: Discussionmentioning

confidence: 99%

“…Severely disabled children sometimes need an elemental diet because of some absorption difficulty in the gut. It is known that enteral nutrition induces colonic and intestinal mucosal atrophy 12 and a gastrointestinal microflora change 7 as adverse effects. Although the pathologic findings in the gastrointestinal tracts of severely disabled children after a long-term elemental diet were not well known, Iai and Yamada 13 reported intestinal mucosal atrophy in a severely disabled person after 25 years of enteral nutrition.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin K Deficiency in Severely Disabled Children

et al. 2003

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Vitamin K status was examined in 21 severely disabled children in our hospital from September 2001 to August 2002, and 9 children were found to have a vitamin K deficiency. The 21 patients were divided into two groups: group A, 9 patients with vitamin K deficiency, and group B, 12 patients without vitamin K deficiency. The laboratory data and background factors in the two groups were compared statistically. In group A, all patients received enteral nutrition and anticonvulsants. The protein induced by vitamin K absence-II values were elevated in eight patients. Seven exhibited a bleeding tendency. Six developed vitamin K deficiency in association with infection and four were treated with antibiotics. All showed a good response to the administration of vitamin K. The patients in group A had factors such as use of antibiotics, infection, and elemental nutrition at significantly higher rates than those in group B. Data indicating nutrition factors such as body weight, caloric intake, total protein level, and hemoglobin level were not significantly different between the two groups. Severely disabled children suffer from deficiencies of various nutritional elements. However, vitamin K deficiency in severely disabled children has not been fully investigated. Infection, use of antibiotics, and elemental nutrition are risk factors for vitamin K deficiency in severely disabled children. In severely disabled children, there might be marginal vitamin K intake via enteral nutrition, so more vitamin K supplementation is necessary, especially with infection and use of antibiotics.

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