Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats

Kim, Jong Gun; Lee, Eungsuk; Kim, Sae Hun; Whang, Kwang Youn; Oh, Sejong; Imm, Jee-Young

doi:10.1016/j.idairyj.2009.06.009

Cited by 55 publications

(38 citation statements)

References 27 publications

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“…Further evidence for probiotics having a direct effect on bone cells has been observed with L. helveticus and L. casei. In MC3T3-E1 cultures L. casei – fermented milk increased proliferation in a dose-dependent manner (75). Also, addition of L. helveticus -fermented milk products to primary bone marrow cultures increased calcium accumulation in osteoblast cultures suggesting that it has the potential to increase osteoblast differentiation.…”

Section: Probioticsmentioning

confidence: 99%

The Potential of Probiotics as a Therapy for Osteoporosis

Collins¹,

Rios‐Arce²,

Schepper³

et al. 2017

Microbiol Spectr

126

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Osteoporosis, characterized by low bone mass and micro-architectural deterioration of bone tissue with increased risk of fracture, can be categorized into two forms: primary or secondary, depending on whether it occurs as part of the natural aging process (estrogen-deficiency) or as part of disease pathology. In both forms bone loss is due to an imbalance in the bone remodeling process with resorption/formation skewed more toward bone loss. Recent studies and emerging evidence consistently demonstrate the potential of the intestinal microbiota to modulate bone health. The current chapter discusses the process of bone remodeling and the pathology of osteoporosis and introduces the intestinal microbiota and its potential to influence bone health. In particular, we highlight recent murine studies that examine how probiotic supplementation can both increase bone density in healthy individuals as well as protect against primary (estrogen-deficiency) as well as secondary osteoporosis. Potential mechanisms are described to account for how probiotic treatments could be exerting their beneficial effect on bone health.

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Section: Probioticsmentioning

confidence: 99%

The Potential of Probiotics as a Therapy for Osteoporosis

Collins¹,

Rios‐Arce²,

Schepper³

et al. 2017

Microbiol Spectr

126

View full text Add to dashboard Cite

show abstract

“…Besides, Kim et al [21] indicated that decreased level of BMD in OVX rats will be significantly improved by administrating Lactobacillus casei 393 from fermented milk. They assessed the breaking force using a Texture Analyzer.…”

Section: Probiotics and Bones: Animal Studiesmentioning

confidence: 99%

Effect of Probiotics Supplementation on Bone Mineral Content and Bone Mass Density

Parvaneh

Jamaluddin

Karimi

et al. 2014

The Scientific World Journal

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A few studies in animals and a study in humans showed a positive effect of probiotic on bone metabolism and bone mass density. Most of the investigated bacteria were Lactobacillus and Bifidobacterium . The positive results of the probiotics were supported by the high content of dietary calcium and the high amounts of supplemented probiotics. Some of the principal mechanisms include (1) increasing mineral solubility due to production of short chain fatty acids; (2) producing phytase enzyme by bacteria to overcome the effect of mineral depressed by phytate; (3) reducing intestinal inflammation followed by increasing bone mass density; (4) hydrolysing glycoside bond food in the intestines by Lactobacillus and Bifidobacteria. These mechanisms lead to increase bioavailability of the minerals. In conclusion, probiotics showed potential effects on bone metabolism through different mechanisms with outstanding results in the animal model. The results also showed that postmenopausal women who suffered from low bone mass density are potential targets to consume probiotics for increasing mineral bioavailability including calcium and consequently increasing bone mass density.

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“…It produces active molecules such as epidermal growth factor, insulin-like growth factor, and fibroblast growth factor that can help stimulate the growth or differentiation of various cells, including bone cells (Kim et al 2015). Additionally, milk protein-derived peptides and casein phosphopeptides are generated during fermentation, which are considered to be the active components of FMPs that can modulate physiological functions (Kim et al 2009). Although the active components of FMP-B719 were not confirmed in the present study, supplementation with FMP-B719 resulted in a significant increase in the viability and differentiation of pre-osteoblastic MC3T3-E1 cells.…”

Section: Resultsmentioning

confidence: 99%

Bone‐protective effects of Lactobacillus plantarum B719‐fermented milk product

Lee

Kim

2020

Int J of Dairy Tech

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The current study aimed to investigate the anti-osteoporotic effects of a Lactobacillus plantarum B719-fermented milk product (FMP-B719). Higher proliferation and mineralisation were observed in FMP-B719-treated MC3T3-E1 mouse pre-osteoblastic cells than those in L. casei ATCC 393-FMP-treated MC3T3-E1 cells. Moreover, FMP-B719 normalised the serum alkaline phosphatase (9.37 AE 1.92 U/L) and phosphorus (8.28 AE 0.1 mg/dL) in a rat model of ovariectomy-induced postmenopausal osteoporosis. Furthermore, FMP-B719 normalized the bone volume in the proximal femur and increased the femur strength that was decreased in ovariectomized rats. Hence, the results of this study suggest that FMP-B719 could serve as a potential candidate for the treatment and prevention of postmenopausal osteoporosis.

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Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats

Cited by 55 publications

References 27 publications

The Potential of Probiotics as a Therapy for Osteoporosis

The Potential of Probiotics as a Therapy for Osteoporosis

Effect of Probiotics Supplementation on Bone Mineral Content and Bone Mass Density

Bone‐protective effects of Lactobacillus plantarum B719‐fermented milk product

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