Effects of a homogeneous polysaccharide from Sijunzi decoction on human intestinal microbes and short chain fatty acids in vitro

Gao, Beibei; Wang, Ruijun; Peng, Ying; Li, Xiaobo

doi:10.1016/j.jep.2018.06.006

Cited by 75 publications

(41 citation statements)

References 45 publications

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“…(Kong et al , ; Chen et al , ). There are similar results in the simulated digestion of other polysaccharides in vitro (Gao et al , ; Hu et al , ; Xu et al , ). Little is known about the specific mechanism of degrading complex seaweed polysaccharides (EI et al , ).…”

Section: The Digestive Behaviour Of Bspsupporting

confidence: 65%

Beneficial effects of three brown seaweed polysaccharides on gut microbiota and their structural characteristics: An overview

You

Gong

et al. 2019

Int J of Food Sci Tech

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Summary The gut microbiota appears critical in the metabolic health and anti‐disease activity. In this review, we discuss three brown seaweed polysaccharides (alginate, laminarin, fucoidan) for their structural information, the digestive behaviour and the effects on gut microbiota. Bioactivities are associated with various physicochemical properties, like solubility, viscosity, hydration properties, molecular weight, monosaccharide composition, and so on. Brown seaweed polysaccharides can be completely utilised by microbes in the large bowel, and they can regulate the gut microbiota. The ultimate metabolite of these polysaccharides is mainly short‐chain fatty acids, which are able to regulate the ecology of the gut microbiota by increasing the growth of beneficial bacteria and inhibiting the growth of some harmful bacteria. In addition, this article also discusses the relationship between the structure and activity of modulating the gut microbiota. Results show that polysaccharides with low molecular weight are more conductive to modulate gut microbiota.

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Section: The Digestive Behaviour Of Bspsupporting

confidence: 65%

Beneficial effects of three brown seaweed polysaccharides on gut microbiota and their structural characteristics: An overview

You

Gong

et al. 2019

Int J of Food Sci Tech

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“…Our previous study has indicated that S-3, the immunocompetent polysaccharide fraction screened from SJZDP could enhance the immune function of spleendeficiency rats [14] by restoring the disturbance of gut microbiota and increasing the content of short-chain fatty acids. Furthermore, we isolated and purified an immunemodulating polysaccharide (S-3-1) from the S-3 fraction [14,15] and found that the chemical composition of this polysaccharide and sugar residue connection were different from seven homogeneous polysaccharides from four crude drugs (Radix Ginseng, Rhizoma Atractylodis Macrocephalae, Poria, and Radix Glycyrrhizae) of SJZD using the same preparation method [16]. Recently, we isolated and purified a new water-soluble polysaccharide (S-3-AG) from the S-3 fraction; the information on the conformation of S-3-AG is required, and its structure-activity relationships were unclear.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Characterization and Its Actions on Immunocompetent Cells of Polysaccharides from Sijunzi Decoction

Gao

Peng

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Sijunzi decoction (SJZD) is a classic recipe in Traditional Chinese Medicine (TCM) with strong immune-enhancement activity. To further understand the characterization and immunomodulatory effect of polysaccharides from SJZD, the monosaccharide compositions of crude polysaccharide (SJZDP), polysaccharide fraction (S-3), and homogeneous polysaccharide (S-3-AG) from SJZD were compared by GC analysis, as well as their immunomodulatory effects on Peyer’s patch cells, splenocytes, and macrophages which are related to intestinal immunity, specific immunity, and nonspecific immunity. The results showed that S-3-AG mainly contained Ara with a proportion of 38.9%, while Glc accounted for the largest proportion in S-3 (55.6%) and SJZDP (87.6%). The SJZDP, S-3, and S-3-AG all showed strong capability to stimulate Peyer’s patch cells to proliferate and produce IgA and promoted the proliferation and IFN-γ production of splenocytes and increased the NO production and TNF-α production of macrophages. However, S-3 and S-3-AG were able to stimulate splenocytes to secret IL-4, SJZDP had no effect on IL-4 production of splenocytes in the tested concentrations. In addition, S-3 could stimulate the phagocytic activity of macrophages, and S-3-AG restrained the proliferation of macrophages at the concentration of 50–200 µg/mL. These results suggested that SJZDP, S-3, and S-3-AG might have different immunomodulatory effects on intestinal immunity, specific immunity, and nonspecific immunity due to their different monosaccharide compositions. It will provide references for the material basis and mechanism of SJZD immunomodulation activity.

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“…e anti-CRC effect of TCM is closely related to gut microbiota ( Table 2). Enterotoxin-producing Bacteroides fragilis (ETBF) is a key pathogen that promotes tumor cell proliferation and promotes CRC progression [61], Dahuang Mudan prescription can significantly inhibit the proliferation [63]. Shenling Baizhu powder can increase probiotics, and reduce intestinal endotoxin and inflammatory factors in the intestine of the mice [64].…”

Section: Intestinal Flora Provides a New Target For The Prevention Anmentioning

confidence: 99%

The Relationship between Prevention and Treatment of Colorectal Cancer and Cancerous Toxin Pathogenesis Theory Basing on Gut Microbiota

Sang

Qiu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Gut microbiota is a diverse consortium of bacteria, fungi, protozoa, and viruses in the gut of all mammals. Gut microbiota remains in steady state under normal conditions. Changes in the internal and external environment may cause gut Microbiota to be out of tune. Malignant tumors are one of the major diseases currently endangering human health. CRC (colorectal cancer) has a significant upward trend in morbidity and mortality in many parts of the world. Technological advances have not yet brought about a breakthrough in the efficacy of CRC. The development of colon cancer is closely related to gut microbiota imbalance. According to more than 60 years of clinical practice, Professor Zhongying Zhou first proposed the pathogenesis theory of “cancerous toxin” in the 1990s and believed that cancerous toxin was a key pathogenesis of tumor development. Under the guidance of the theory of cancerous toxin, combined with clinical practice, Professor Zhou created an effective anticancer Chinese herbal compound, Jiedu Xiaoai Prescription. This paper summarizes recent hotspots related to gut microbiota and the occurrence, development, and prevention of colon cancer at home and abroad. The relationship between gut microbiota and cancerous toxin theory is proposed, and the feasibility of further studying the biological basis of cancerous toxin pathogenesis theory from the perspective of gut microbiota is pointed out.

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Effects of a homogeneous polysaccharide from Sijunzi decoction on human intestinal microbes and short chain fatty acids in vitro

Cited by 75 publications

References 45 publications

Beneficial effects of three brown seaweed polysaccharides on gut microbiota and their structural characteristics: An overview

Beneficial effects of three brown seaweed polysaccharides on gut microbiota and their structural characteristics: An overview

A Comparison of Characterization and Its Actions on Immunocompetent Cells of Polysaccharides from Sijunzi Decoction

The Relationship between Prevention and Treatment of Colorectal Cancer and Cancerous Toxin Pathogenesis Theory Basing on Gut Microbiota

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