Effects of a Homeopathic Combination Remedy on the Acute Stress Response, Well-Being, and Sleep: A Double-Blind, Randomized Clinical Trial

Hellhammer, Juliane; Schubert, Melanie

doi:10.1089/acm.2010.0636

Cited by 7 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All of these studies suggest that less acute stress and better social support system would greatly reduce sleep disorders and improve significantly sleep quality. However, another study by Hellhammer et al proved that neuroendocrine response mechanism induced by acute stress played a positive role in improving sleep quality [ 19 ], which was inconsistent with our study. The reasons of the inconsistent might be that, the kinds of the participants were different, then the acute stress could be different either.…”

Section: Discussioncontrasting

confidence: 99%

Relationship between acute stress and sleep disorder in grass-root military personnel: mediating effect of social support

Zhang¹,

Zhang

Sun

et al. 2014

Military Med Res

View full text Add to dashboard Cite

BackgroundSleep disorder induced by acute stress has always been an important topic for study among the general population. However, the mediating effect of social support between acute stress and sleep disorder has rarely been reported before.MethodsA total of 2,411 grass-root military personnel were randomly selected by cluster sampling, and administered the Chinese Military Personnel Sleep Disorder Scale, Military Acute Stress Scale and Social Support Rating Scale.ResultsThe total score of acute stress scale was positively correlated with the total score and factor scores of sleep disorder scale (r = 0.209 ~ 0.465, P < 0.01); The total score of social support scale was positively correlated with the total score of acute stress scale and the total score and factor scores of sleep disorder scale (r = 0.356 ~ 0.537, P < 0.01). The analysis of mediating effects showed that lack of social support partially mediated between acute stress and the factors of sleep disorder. The analysis of structural equation model showed that acute stress not only had a direct effect on sleep disorder (the path coefficient was 0.29, P = 0.000), but also on lack of social support (the path coefficient was 0.39, P = 0.000); lack of social support had a direct effect on sleep disorder (the path coefficient was 0.48, P = 0.000).ConclusionsAcute stress and lack of social support are two significant factors of sleep disorder in grass-root military personnel. Well-established social support could alleviate sleep disorder induced by acute stress. Lack of social support was a partial mediator between acute stress and sleep disorder.

show abstract

Section: Discussioncontrasting

confidence: 99%

Relationship between acute stress and sleep disorder in grass-root military personnel: mediating effect of social support

Zhang¹,

Zhang

Sun

et al. 2014

Military Med Res

View full text Add to dashboard Cite

show abstract

“…Present knowledge from basic research into homeopathic complex remedies is rather limited. Though there are clinical studies in this field, which have tested the effectiveness of homeopathic complex remedies, 23 24 25 we are not aware of sustained basic research activities providing insight into homeopathic complex remedies' mechanisms of action, possible interactions between their components, or the function of different components and their ratios. Homeopathic complex remedies, despite their long tradition, seem to represent a new field of basic research, which has many unanswered questions regarding for instance the correct study methods to apply.…”

Section: Discussionmentioning

confidence: 99%

Self-assembled Patterns Formed in Evaporating Droplets to Analyze Bi-component Homeopathic Preparations in the Low Dilution Range

2023

View full text Add to dashboard Cite

Background Homeopathic complex remedies, composed of several homeopathic medicines in the low potency range, are frequently used in the treatment of a number of common disorders. At the same time, they represent an almost unexplored area of research. Are complex remedies just additive mixtures of the components, or are there interactions between the latter leading to new properties of the complex? Methods In the present study, we analyzed as an example the simple bi-component complex, Luffa 4x – Mercurius bijodatus 9x, by means of patterns from evaporated droplets and tested what influences the complex's single compounds have upon the patterns and if there are any interactions. For this purpose, we compared in a series of five experiments patterns from evaporated droplets of the complex, Luffa 4x – Mercurius bijodatus 9x, and three comparison samples in which one or both of the complex's compounds were replaced by potentized solute. The patterns were photographed and evaluated for their gray-level distribution and texture using the software ImageJ. The experimental set-up's stability was tested by means of systematic control experiments. Results We found that Mercurius bijodatus 9x significantly influenced the patterns of Luffa 4x, increasing their homogeneity; at the same time, the patterns of Mercurius bijodatus 9x combined with solvent were more heterogeneous than those obtained from a control consisting of two pure solvents. Conclusion In this phenomenological assay, the complex Luffa 4x – Mercurius bijodatus 9x does not correspond to a simple addition of the components. The exact nature of the underlying interaction needs to be elucidated in further investigations.

show abstract

“…Since then, one RCT on individualized homeopathy has been published that found a significant increase in the duration of sleep throughout the study in favor of homeopathy compared to placebo [ 17 ]. Another RCT with a complex homeopathic medicinal product reported that homeopathic treatment significantly increased sleep quality compared to placebo treatment [ 18 ]. Clearly, further studies are needed to establish the efficacy of homeopathy in the treatment of insomnia.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Randomized Controlled Clinical Trial on the Effectiveness, Safety, and Tolerability of a Homeopathic Medicinal Product in Children with Sleep Disorders and Restlessness

Jong

Ilyenko

Холодова

et al. 2016

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

A prospective, multicenter, randomized, open-label, controlled clinical trial was performed to evaluate the effectiveness and safety of the homeopathic product ZinCyp-3-02 in children with sleep disorders for ≥ one month compared to glycine. Children ≤ six years old received either ZinCyp-3-02 (N = 89) or comparator glycine (N = 90). After treatment for 28 days, total sleep-disorder-associated complaints severity scores decreased in both groups from median 7.0 (out of maximum 11.0) points to 2.0 (ZinCyp-3-02) and 4.0 (glycine) points, respectively, with overall higher odds of showing improvement for ZinCyp-3-02 (odds ratio: 4.45 (95% CI: 2.77–7.14), p < 0.0001, POM overall treatment related effect). Absence of individual complaints (time to sleep onset, difficulties maintaining sleep, sleep duration, troubled sleep (somniloquism), physical inactivity after awakening, restlessness for unknown reason, and sleep disorders frequency) at study end were significantly higher with ZinCyp-3-02 (all p values < 0.05). More children with ZinCyp-3-02 were totally free of complaints (p = 0.0258). Treatment effectiveness (p < 0.0001) and satisfaction assessments (p < 0.0001) were more favorable for ZinCyp-3-02. Few nonserious adverse drug reactions were reported (ZinCyp-3-02: N = 2, glycine: N = 1) and both treatments were well tolerated. Treatment with the homeopathic product ZinCyp-3-02 was found to be safe and superior to the comparator glycine in the treatment of sleep disorders in children.

show abstract

Effects of a Homeopathic Combination Remedy on the Acute Stress Response, Well-Being, and Sleep: A Double-Blind, Randomized Clinical Trial

Cited by 7 publications

References 30 publications

Relationship between acute stress and sleep disorder in grass-root military personnel: mediating effect of social support

Relationship between acute stress and sleep disorder in grass-root military personnel: mediating effect of social support

Self-assembled Patterns Formed in Evaporating Droplets to Analyze Bi-component Homeopathic Preparations in the Low Dilution Range

A Comparative Randomized Controlled Clinical Trial on the Effectiveness, Safety, and Tolerability of a Homeopathic Medicinal Product in Children with Sleep Disorders and Restlessness

Contact Info

Product

Resources

About