Effects of a high protein diet on cognition and brain metabolism in cirrhotic rats

Méndez-López, Magdalena; Méndez, Marta; Árias, Jorge L.

doi:10.1016/j.physbeh.2015.05.038

Cited by 12 publications

(9 citation statements)

References 55 publications

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“…Despite the animals in groups P and especially those in group G showing less weight gain after 72 or 182 days treatment, the behavior in EPM was similar to animals in groups C, GL and L. These data match those in the literature when animals were treated with a diet rich in sucrose [5,6], rich in protein [20] and rich in lipids [7,9,10,16] and also showed no change when tested in the EPM. However, the diet rich in lipids had an anxiolytic [13] and anxiogenic effect [11,12,14,15,17].…”

Section: Discussionsupporting

confidence: 87%

“…The assessment of anxiety in animals treated with obesogenic diets (rich in carbohydrates [5,6], lipids [7][8][9][10][11][12][13][14][15][16][17] and carbohydrates and lipids [18,19]) is controversial. For some authors, the diet did not change the behavior in the EPM [5][6][7]9,10,16,20], for others it increased [8,11,12,14,15,[17][18][19] or reduced anxiety [13].…”

Section: Introductionmentioning

confidence: 97%

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Feed restriction since lactation has reduced anxiety in adult Wistar rats

Riul

Almeida

2020

Rev. Nutr.

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Objective To evaluate the effects of macronutrients (protein, carbohydrate and/or lipid) in the diet of young adult (72 days) and adult (182 days) Wistar rats treated ad libitum and with 30% restriction from birth on anxiety in the elevated plus-maze. Methods We used 238 rats treated from birth, composing the groups: Control, Protein, Carbohydrate, Lipid, Carbohydrate and Lipid, Control Restriction, Protein Restriction, Carbohydrate Restriction, Lipid Restriction and Carbohydrate and Lipid Restriction. The animals were weighed at the beginning and at the end of the experiment and tested in the elevated plus-maze. Data were submitted to analysis of variance, followed by the Newman-Keuls Test (p<0.05). Results Among the animals treated ad libitum, the Control, Carbohydrate plus Lipid and Lipid gained more weight than the Carbohydrate and Protein; ad libitum animals gained more weight than those on restriction; among the restrictions, Carbohydrate Restriction rats were the ones that gained less weight. Diet-restricted animals exhibited reduced first-entry latency, greater percentage of entries and time spent, frequency of open arm extremity visits, head dipping (protected and unprotected), and length of stay in the central area of the elevated plus-maze. The animals with 182 days presented greater latency for first entry, reduced frequency of false entries and visits to the ends of the open arms and protected head dipping. Conclusion Food restricted animals, regardless of the macronutrient present in the diet, were less anxious and/or increased their impulsivity and those at 182 days were more anxious and/or with reduced impulsivity.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 97%

Feed restriction since lactation has reduced anxiety in adult Wistar rats

Riul

Almeida

2020

Rev. Nutr.

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“… 85 Conversely, a high-protein diet worsened memory acquisition in male Wistar rats in the MWM. 86 Most of the studies on dietary amino acids and cognition have focused on Trp because it is a precursor to serotonin, which is a neurotransmitter that regulates learning and memory, and mood. 87 When rats were maintained on a Trp-deficient diet during the first 2 postnatal months, they exhibited impaired memory acquisition in the MWM.…”

Section: Influence Of Individual Macronutrients On Learning and Memormentioning

confidence: 99%

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia

Wahl¹,

Coogan²,

Solon-Biet³

et al. 2017

CIA

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Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Although most interventional studies in rodent models of dementia have focused on pharmacological agents, there are an increasing number of studies that have evaluated nutritional interventions including caloric restriction, intermittent fasting, and manipulation of macronutrients. Dietary interventions have been shown to influence various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration.

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“…Ограничение белка в корме уменьшало дефицит рабочей памяти в Y-лабиринте у мышей [64] и, наоборот, высокобелковая диета ухудшала формирование памяти у самцов крыс линии Wistar в водном лабиринте Морриса [65]. Большинство исследований, связанных с изучением влияния пищевых аминокислот на когнитивные процессы, сосредоточены на изучении триптофана, предшественника серотонина, который является нейротрансмиттером, регулирующим обучение, память и настроение [66].…”

Section: влияние нутриентов на обучение и память у грызуновunclassified

Preclinical in vivo Neurotoxicity Studies of Drug Candidates

Еремина

Колик

Ostrovskaia

et al. 2020

Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo pr

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Neurotoxic effects are one of the common reasons for discontinuation of preclinical and/or clinical studies. Preclinical evaluation of neurotoxic effects is complicated due to a wide range of manifestations and degrees of severity. Current experimental approaches to neurotoxicity assessment are cumbersome, laborious and not adapted enough for preclinical studies in the early stages of drug development. The aim of the study was to review existing approaches to experimental assessment of neurotoxic potential of new drugs and to discuss the need for and feasibility of developing and using integrated rapid neurotoxicity tests for early assessment of a pharmacological project’s potential. The authors reviewed scientific literature and guidance documents and analysed current approaches to chemical compound neurotoxicity assessment in laboratory animals. The paper analyses the main issues of neurotoxicity assessment for new drugs and compares Irwin tests with the functional observation battery. It analyses issues related to assessment of drugs’ effects on the development and maturation of central nervous system functions at pre- and postnatal stages. It was determined that the current practice is not sufficient for assessment of potential adverse effects on cognitive functions. The authors assessed factors affecting cognitive functions of rodents during studies. The “Acute suppression of the exploratory and orientation response” and “Extrapolation escape task” tests were proposed for validation as potential rapid tests for detection of an array of organic and functional neurotoxic disorders at early stages of preclinical studies.

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Effects of a high protein diet on cognition and brain metabolism in cirrhotic rats

Cited by 12 publications

References 55 publications

Feed restriction since lactation has reduced anxiety in adult Wistar rats

Feed restriction since lactation has reduced anxiety in adult Wistar rats

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia

Preclinical in vivo Neurotoxicity Studies of Drug Candidates

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