Effects of a high fat diet on bone of growing rats. Correlations between visceral fat, adiponectin and bone mass density

Lac, G.; Cavalié, H.; Ebal, E.; Michaux, O.

doi:10.1186/1476-511x-7-16

Cited by 50 publications

(55 citation statements)

References 21 publications

(24 reference statements)

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“…One environmental factor that radically impacts bone health is diet: children consuming a high fat and low carbohydrate diet tend to develop a poor bone mineral status that increases bone fragility and future risk of suffering an osteoporotic fracture (Bertoli et al, 2002); similarly, animals consuming a western-style diet high in saturated fat display low bone mass, overall poor bone quality (Ward et al, 2003), diminished bone mineralization (Smith et al, 2000), and decreased calcium absorption and accretion, which collectively exert a negative impact on ABMD (Lac et al, 2008).…”

Section: Introductionmentioning

confidence: 97%

Gestational high saturated fat diet alters C57BL/6 mouse perinatal skeletal formation

Liang

Oest

Jones

et al. 2009

Birth Defects Research Pt B

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The theory of HFD-associated, OS-mediated placental damage and skeletal pathogenesis was supported by demonstrating a protective effect of the dietary antioxidant quercetin (Q) against HFD-associated fetal skeletal developmental delay. Improved understanding of the role of HFD and elevated OS in fetal skeletal development will help to more completely elucidate the importance of the prenatal environment to fetal formation, and will be applied to better understand the contribution of the fetal environment to long-term risk of adult-onset disease.

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Section: Introductionmentioning

confidence: 97%

Gestational high saturated fat diet alters C57BL/6 mouse perinatal skeletal formation

Liang

Oest

Jones

et al. 2009

Birth Defects Research Pt B

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“…However, these contributions varied according to race (10). Indeed, data are conflicting regarding the association of visceral and subcutaneous fat in bone metabolism, with studies reporting positive, negative, or lack of association (12,13).…”

Section: Introductionmentioning

confidence: 99%

Influence of visceral and subcutaneous fat in bone mineral density of obese adolescents

Campos

Lazaretti-Castro

Mello

et al. 2012

Arq Bras Endocrinol Metab

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Objective: To verify the influence of visceral and subcutaneous fat, as well adipokines in bone mineral density (BMD) in obese adolescents. Subjects and methods: The study involved 125 postpubertal obese adolescents (45 boys and 80 girls). Anthropometric measurements, body composition, visceral and subcutaneous fat, and BMD were determined. Leptin, adiponectin, and insulin levels also analyzed. Results: Data demonstrated a negative relationship between BMD with insulin resistance, visceral fat and leptin concentration; and bone mineral content with visceral/subcutaneous ratio. Positive association between BMD and subcutaneous fat was observed. Conclusions: Visceral fat and insulin resistance, as well as visceral/subcutaneous ratio and leptin concentration, were negative predictors of BMD in boys and girls, respectively. However, subcutaneous fat had a protective influence in BMD only in boys. Arq Bras Endocrinol Metab.2012;56(1):12-8 Keywords Adolescent; visceral fat; subcutaneous fat; bone mass RESUMO Objetivo: Verificar a influência da gordura visceral e subcutânea, assim como das adipocinas na densidade mineral óssea (DMO) em adolescentes obesos. Sujeitos e métodos: O estudo envolveu 125 adolescentes obesos pós-púberes. Medidas antropométricas, composição corporal, gordura visceral e subcutânea e DMO foram determinadas. Níveis de leptina, adiponectina e insulina foram analisados. Resultados: Os dados demonstraram associação negativa entre DMO com resistência insulínica, gordura visceral e concentração de leptina; e conteúdo mineral ósseo com a razão visceral/subcutânea. Associação positiva entre DMO e gordura subcutânea foi observada. Conclusões: Gordura visceral, resistência insulínica, razão visceral/subcutânea e concentração de leptina foram preditores negativos da DMO em meninos e meninas, respectivamente. Entretanto, a gordura subcutânea demonstrou exercer influência positivamente na DMO somente nos meninos. Arq Bras Endocrinol Metab. 2012;56(1):12-8 Descritores Adolescente; gordura visceral; gordura subcutânea; massa óssea

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“…In growing animal models, a HFD or high-energy diet could deleteriously affect bone mineral content, structure, and mechanical properties (Li et al 1990;Zernicke et al 1995;Ward et al 2003). In addition, significant correlations were observed between body composition, adiponectin, and bone parameters in growing mice and rats fed a HFD (Lac et al 2008;Devlin et al 2010). Furthermore, it was shown that an atherogenic diet inhibits bone formation by blocking differentiation of osteoblasts in growing mice, possibly resulting from lipid oxidation products (Parhami et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Gene expression profile in bone of diabetes-prone BB/OK rats fed a high-fat diet

et al. 2012

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A high-fat diet (HFD) has been recognized as a risk factor for diseases such as dyslipidemia, atherosclerosis, obesity, and osteoporosis. However, studies analyzing gene expression after HFD in bone are rare. That prompted us to analyze the expression of selected genes in bone of 4-week-old diabetes-prone B(io)B(reeding) rats. Two breeding pairs were fed a HFD (?10 % tallow) or were fed a normal diet (ND; Ssniff R-Z) before mating and afterward during pregnancy. After the birth of progeny, parents continued to be given HFD or ND until the progeny was weaned (3 weeks). Thereafter, offspring were weaned and were fed the same food as their parents up to an age of 4 weeks. Body weight was measured at an age of 4 weeks, and subsequently 13 HFD rats and 13 ND rats were killed and the tibial bone was harvested to analyze the expression of 53 genes in bone. All rats fed HFD were significantly heavier than rats fed ND after 3 and 4 weeks. The diet also influenced the expression of genes in bone. There were significant differences in 20 out of 53 genes studied between rats fed HFD compared with rats fed ND. Four out of 20 had a lower and 17 out of 20 genes a higher expression in HFD rats, but differences in gene expression showed obvious differences between males and females. There were only two genes that were similarly different between males and females: Bmp4 and Atf4. Two genes, Foxg1 and Npy, were inversely expressed in males and females. It seems that the gene expression is differently regulated by diet during pregnancy and later in life between males and females. Nevertheless, it cannot be excluded that HFD also acts as an epigenetic factor in the development of offspring in utero.

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Effects of a high fat diet on bone of growing rats. Correlations between visceral fat, adiponectin and bone mass density

Cited by 50 publications

References 21 publications

Gestational high saturated fat diet alters C57BL/6 mouse perinatal skeletal formation

Gestational high saturated fat diet alters C57BL/6 mouse perinatal skeletal formation

Influence of visceral and subcutaneous fat in bone mineral density of obese adolescents

Gene expression profile in bone of diabetes-prone BB/OK rats fed a high-fat diet

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