“…Free iron catalyzes the conversion of superoxide and hydrogen peroxide into hydroxyl radicals, which promote oxidative stress by the Fenton reaction (Berg et al, 2001). Furthermore, ROS interacts with a variety of molecules, including unsaturated fatty acids, proteins and DNA leading to subsequent cell death/apoptosis, especially on CNS tissue, whereas the antioxidant defenses are rare (Demougeot et al, 2003;Stankiewicz & Brass, 2009;Willmore & Rubin, 1984). Thus, disturbances of brain iron homeostasis have been linked to acute neuronal injury leading to neurodegenerative disorders (Campbell & Bondy, 2000;Montgomery, 1995) such as Alzheimer's (AD), Parkinson's (PD), and Huntington's (HD) diseases as well as amyotrophic lateral sclerosis (ALS) (Connor & Benkovic, 1992;Kell, 2010;Liu et al, 2006;Rouault, 2001;Youdim et al, 2005).…”