Brain changes in iron loading disorders

Milward, Elizabeth A.; Acikyol, Bulent; Bassett, Brianna; Williams, Evan J.; Graham, Ross M.; Delima, Roheeth D.; Trinder, Deborah; Olynyk, John K.; Johnstone, Daniel M.

doi:10.1007/978-3-7091-1001-0_2

Cited by 5 publications

(7 citation statements)

References 74 publications

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“…However, no abnormalities or damage to the contour of liver surface contour generated from all treatments ( Table 2). The invisibility effect on the contour conditions of excess iron could be caused by the delayed effect where the excess iron accumulated in the organs and tissues of the body were not directly visible but were accumulative and could appear in the long term [15]. In coherence with literature, damage or deterioration of liver function are sometimes not visible on the morphological structure of the liver and could be observed on the histological structure of liver [16].…”

Section: Morphometry Of Livermentioning

confidence: 55%

“…Inflammation that follows the pattern of blood flow appeared to be the most frequent cause of hepatitis or liver inflammation [15].…”

Section: Histological Structure Of the Livermentioning

confidence: 99%

“…This could be due to abnormalities of hepatocyte such cytoplasmic vacuolization in the liver lobule because of toxic free radicals [15].…”

Section: Histological Structure Of the Livermentioning

confidence: 99%

“…This indicates that sappan wood extract with dose of 50 mg kg −1 bw day −1 , vitamin E and wheat grass could act as hepatoprotective effects that can protect the liver from free radical damage caused by iron overload conditions. Nevertheless, the hepatoprotective effect of each antioxidant is not optimal because given alone [15].…”

Section: Histological Structure Of the Livermentioning

confidence: 99%

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The Effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the Liver Structure of Iron overload of Rat (Rattus norvegicus)

Safitri

Reniarti

Madihah

et al. 2017

KLS

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This research was carried out to detect the effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the liver structure of iron overload rat (Rattus norvegicus).The method of experimental used Completely Random Design (CRD in triple repetition. The treatment had been carried out orally. Iron dextran with total dose of 1.5 g kg −1 of body were given to rat on the first, fourth, seventh, ten and thirteenth day. Sappan Wood Extract (Caesalpinia sappan)200 mg kg −1 bw, 400 mg kg −1 bw, Wheat grass extract 100 mg kg −1 bw and Vitamin E 60 mg kg −1 bw were given to rat everyday for 15 days. At the seventeenth, rat were killed and their liver were taken. The observed parameters are morphological abnormality including the colour, the contour, ratio between liver weight and body weight as well as histological destruction. The result showed iron dextran treatment was proved the abnormality on morphological and histological desruction. Futhermore, Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment can decrease the morphological abnormality and the liver histological destructionon of iron overload rat.

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Section: Morphometry Of Livermentioning

confidence: 55%

“…Inflammation that follows the pattern of blood flow appeared to be the most frequent cause of hepatitis or liver inflammation [15].…”

Section: Histological Structure Of the Livermentioning

confidence: 99%

“…This could be due to abnormalities of hepatocyte such cytoplasmic vacuolization in the liver lobule because of toxic free radicals [15].…”

Section: Histological Structure Of the Livermentioning

confidence: 99%

Section: Histological Structure Of the Livermentioning

confidence: 99%

See 2 more Smart Citations

The Effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the Liver Structure of Iron overload of Rat (Rattus norvegicus)

Safitri

Reniarti

Madihah

et al. 2017

KLS

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“…The consequences of iron deficiency are expressed in adulthood, preventing the full realization of the inherent genetic potential [14][15][16][17][18].…”

mentioning

confidence: 99%

Anemia in Women of Reproductive Age

Solovyeva¹,

Gace²,

Ermolenko³

et al. 2018

Current Topics in Anemia

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Anemia is a common condition in women of childbearing age which is associated with wide spread hyperplastic processes in the uterus (leiomyomas, etc.) and abnormal and/ or abundant uterine bleeding (AUB). Our study has considered the main causes of bleeding and the therapy aimed on limiting the amount of blood loss, as well as preoperative treatment of iron deficiency in women with uterine leiomyomas, planning for pregnancy.The combination of anemia with other abnormalities in the woman's health status is associated with complications during pregnancy such as premature births, the birth of small children and failure of the formation of neural tube in iron deficiency and hypoxia. During the treatment of iron deficiency anemia (IDA) with saline iron, we noted severity and pain in the stomach in 11.9% of patients, nausea in 13.1%, constipation in 21.4%, and diarrhea in 7.1% of women. Such complications did not occur while treating with ferric iron. The use of drugs Iron III hydroxide polymaltozate in women after the end of lactation resulted in normalization of the blood hemoglobin within 30 days and the number of erythrocytes and of serum ferritin by the 90th day.

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Transport of Non-Transferrin Bound Iron to the Brain: Implications for Alzheimer’s Disease

Tripathi

Karmakar

Asthana

et al. 2017

JAD

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A direct correlation between brain iron and Alzheimer’s disease (AD) raises questions regarding the transport of non-transferrin-bound iron (NTBI), a toxic but less researched pool of circulating iron that is likely to increase due to pathological and/or iatrogenic systemic iron overload. Here, we compared the distribution of radiolabeled-NTBI (59Fe-NTBI) and transferrin-bound iron (59Fe-Tf) in mouse models of iron overload in the absence or presence of inflammation. Following a short pulse, most of the 59Fe-NTBI was taken up by the liver, followed by the kidney, pancreas, and heart. Notably, a strong signal of 59Fe-NTBI was detected in the brain ventricular system after 2 h, and the brain parenchyma after 24 h. 59Fe-Tf accumulated mainly in the femur and spleen, and was transported to the brain at a much slower rate than 59Fe-NTBI. In the kidney, 59Fe-NTBI was detected in the cortex after 2 h, and outer medulla after 24 hours. Most of the 59Fe-NTBI and 59Fe-Tf from the kidney was reabsorbed; negligible amount was excreted in the urine. Acute inflammation increased the uptake of 59Fe-NTBI by the kidney and brain from 2–24 hours. Chronic inflammation, on the other hand, resulted in sequestration of iron in the liver and kidney, reducing its transport to the brain. These observations provide direct evidence for the transport of NTBI to the brain, and reveal a complex interplay between inflammation and brain iron homeostasis. Further studies are necessary to determine whether transient increase in NTBI due to systemic iron overload is a risk factor for AD.

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Brain changes in iron loading disorders

Cited by 5 publications

References 74 publications

The Effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the Liver Structure of Iron overload of Rat (Rattus norvegicus)

The Effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the Liver Structure of Iron overload of Rat (Rattus norvegicus)

Anemia in Women of Reproductive Age

Transport of Non-Transferrin Bound Iron to the Brain: Implications for Alzheimer’s Disease

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