Effects of a constant‐rate infusion of dexmedetomidine on the minimal alveolar concentration of sevoflurane in ponies

Gozalo-Marcilla, Miguel; Hopster, Klaus; Gasthuys, Frank; Hatz, L.; Krajewski, A. E.; Schauvliege, Stijn

doi:10.1111/j.2042-3306.2012.00613.x

Cited by 39 publications

(35 citation statements)

References 33 publications

(69 reference statements)

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“…Dexmedetomidine induces antinociception in conscious dogs, cats, rats and human beings (Sabbe et al, 1994;Slingsby et al, 2009;Aydogan et al, 2013;Kosharskyy et al, 2013) and reduces the requirements for inspired anaesthetic gas in dogs (Pascoe et al, 2006;Uilenreef et al, 2008), cats (de Souza et al, 2010 and horses (Gozalo-Marcilla et al, 2013a, 2013b, 2013c. In the present study, we determined the antinociceptive effects of dexmedetomidine infusions in conscious horses.…”

Section: Discussionmentioning

confidence: 89%

“…α-2 Agonists are used as constant rate infusions (CRI) during anaesthesia to provide antinociception and to reduce the requirement for inhaled anaesthetic agents in horses (Bettschart-Wolfensberger et al, 2001Gozalo-Marcilla et al, 2013a, 2013b, 2013c. Antinociception with dexmedetomidine is mediated primarily through α-2a receptors in the spinal cord (Yaksh, 1985;Takano and Yaksh, 1991;Guo et al, 1996;Zhao et al, 2013), but an effect within the locus coeruleus also produces antinociception (Guo et al, 1996;Funai et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses

Risberg

Spadavecchia

Ranheim

et al. 2014

The Veterinary Journal

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 98%

Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses

Risberg

Spadavecchia

Ranheim

et al. 2014

The Veterinary Journal

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“…On the other hand, others reported that medetomidine CRI reduced the MAC of desflurane by 28% [16] and that dexmedetomidine CRI reduced the MAC of sevoflurane by 53% [22] in experimental ponies. These results indicate that experimental MAC reduction study is desirable to detect correct anesthetic-sparing effects.…”

Section: Discussionmentioning

confidence: 92%

Effects of Medetomidine Constant Rate Infusion on Sevoflurane Requirement, Cardiopulmonary Function, and Recovery Quality in Thoroughbred Racehorses Undergoing Arthroscopic Surgery

Tokushige

Ohta

Okano

et al. 2015

Journal of Equine Veterinary Science

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“…It is often administered as a continuous rate infusion (CRI), either to treat painful conditions or to decrease the amount of inhalation anaesthetics during general anaesthesia (Gozalo-Marcilla et al 2013, Gozalo-Marcilla et al 2015. Three escalating CRI doses (2, 4, and 6 µg/kg/h) were investigated to determine which CRI is the minimal necessary to provide consistent antinociception in conscious horses (Risberg et al 2014).…”

Section: Alpha-2 Agonistsmentioning

confidence: 99%

The model of the Nociceptive Withdrawal Reflex in horses

Spadavecchia¹,

Rohrbach²,

Levionnois³

et al. 2016

PHK

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Summary: In equine pain research, the Nociceptive Withdrawal Reflex (NWR) model has been proposed as an alternative to classical thermal, mechanical and electrical models to investigate the physiology of nociception. This model does not only allow a more reliable definition of the nociceptive threshold through neurophysiological characterization of the elicited response , but also consents plotting a stimulus-response curve as well as the evaluation of temporal summation mechanisms. Aim of this report is to summarize the experience and results obtained using the NWR model in horses over the last 15 years, firstly with the purpose of describing its physiological characteristics and secondly with the aim of evaluating its pharmacological modulation through analgesic and anaesthetic compounds. The NWR can be elicited in horses through electrical transcutaneous stimulation of a peripheral sensory nerve and is recorded through electromyographic electrodes from the muscles involved in the withdrawal reaction. As the non-nociceptive fibres have lower threshold to electrical stimuli than the nociceptive one, it is impossible to differentiate between the two groups on the stimulus side. So, the only guidance to assess the quality of the stimulus and the recruitment of nociceptive afferents should rely on the characteristics of the electromyographic response, most of all on the timing of its various components. A reflex response can be considered to be a true NWR only if it appears within a time epoch compatible with the conduction velocity of the A fibers. Furthermore a clearly recognizable EMG burst in the epoch of interest has to be accompanied by a consistent aversive behavioural reaction, thus allowing the definition of a reliable NWR threshold. Responses to stimulation intensities below and above thresholds can be quantified to draw a stimulus response curve. Furthermore, through repeated stimulation at subthreshold intensities, it is possible to elicit the phenomenon of temporal summation, considered to be the early phase of the wind up phenomenon and of relevant interest to study central integrative mechanisms of pain processing. Alpha-2 agonists, opioids, systemic lidocaine, ketamine and inhalation anaesthetics have been investigated using the NWR model in horses. Drug-specific modulation of NWR threshold, stimulus-response curves and temporal summation are summarized for each tested compound.

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Effects of a constant‐rate infusion of dexmedetomidine on the minimal alveolar concentration of sevoflurane in ponies

Abstract: A dexmedetomidine CRI at the reported dose significantly reduces the MAC of sevoflurane.

Cited by 39 publications

References 33 publications

Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses

Antinociceptive effects of three escalating dexmedetomidine and lignocaine constant rate infusions in conscious horses

Effects of Medetomidine Constant Rate Infusion on Sevoflurane Requirement, Cardiopulmonary Function, and Recovery Quality in Thoroughbred Racehorses Undergoing Arthroscopic Surgery

The model of the Nociceptive Withdrawal Reflex in horses

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