Effects of a constant rate infusion of detomidine on cardiovascular function, isoflurane requirements and recovery quality in horses

Schauvliege, Stijn; Marcilla, Miguel Gozalo; Verryken, Kirsten; Duchateau, Luc; Devisscher, Lindsey; Gasthuys, Frank

doi:10.1111/j.1467-2995.2011.00659.x

Cited by 42 publications

(44 citation statements)

References 23 publications

(52 reference statements)

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“…In the previous studies carried out using methods similar to our study, CRIs of detomidine [21] or dexmedetomidine [19] failed to reduce the dose of isoflurane required for maintenance in horses undergoing routine surgical procedure. On the other hand, others reported that medetomidine CRI reduced the MAC of desflurane by 28% [16] and that dexmedetomidine CRI reduced the MAC of sevoflurane by 53% [22] in experimental ponies.…”

Section: Discussioncontrasting

confidence: 57%

Effects of Medetomidine Constant Rate Infusion on Sevoflurane Requirement, Cardiopulmonary Function, and Recovery Quality in Thoroughbred Racehorses Undergoing Arthroscopic Surgery

Tokushige

Ohta

Okano

et al. 2015

Journal of Equine Veterinary Science

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Section: Discussioncontrasting

confidence: 57%

Effects of Medetomidine Constant Rate Infusion on Sevoflurane Requirement, Cardiopulmonary Function, and Recovery Quality in Thoroughbred Racehorses Undergoing Arthroscopic Surgery

Tokushige

Ohta

Okano

et al. 2015

Journal of Equine Veterinary Science

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“…Other significant changes included modest decreases in heart and respiratory rates at variable times. These changes were not perceived as clinically important and were likely related to the CRI of detomidine, which is known to cause cardiovascular and respiratory depression . In addition, transient arrhythmias were noted during RRT.…”

Section: Discussionmentioning

confidence: 94%

Renal Replacement Therapy in Healthy Adult Horses

Wong

Witty²,

Alcott

et al. 2013

Veterinary Internal Medicne

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Background: Renal replacement therapy (RRT) has been implemented extensively in people to facilitate recovery from acute renal failure (ARF). RRT has not been explored in horses, but might provide a further treatment option in horses with ARF.Objective: To investigate efficacy and safety of RRT in horses. Animals: Five healthy adult horses. Methods: A prospective study was performed on horses restrained in stocks and intravenously connected to a commercial RRT machine to allow continuous venovenous hemodiafiltration to be performed for 6 hours. The RRT machine was set at the following flow rates: blood flow rate 250 mL/min; dialysate rate 3,000 mL/h; prefilter replacement pump 3,000 mL/h; and postfilter replacement pump rate 2,000 mL/h. Balanced electrolyte solution was used as dialysate and replacement fluid. Heart rate, respiratory rate, body temperature, direct arterial blood pressure, urine output, and various clinicopathologic parameters were measured over the study period.Results: Renal replacement therapy was successfully performed in horses, resulting in a mean creatinine clearance of 0.127 mL/kg/min (68.9 mL/min) and urea reduction ratio of 24%. No adverse effects were detected although a significant decrease in rectal temperature was observed (P .007). A significant increase in serum phosphorus (P .001) and decrease in BUN (P < .001) were also noted. A significant prolongation of prothrombin (P < .01) and partial thromboplastin time (P < .0001) were observed along with a decrease in platelet count (P .04). Conclusions and Clinical Importance: Renal replacement therapy can safely and effectively be used in adult horses.

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“…2004; Devisscher et al. 2010; Schauvliege et al. 2011) as constant rate infusions (CRIs) have been described in clinical and in experimental equine anaesthetic procedures.…”

Section: Introductionmentioning

confidence: 99%

Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses

Marcilla

Schauvliege

Segaert

et al. 2012

Veterinary Anaesthesia and Analgesia

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Effects of a constant rate infusion of detomidine on cardiovascular function, isoflurane requirements and recovery quality in horses

Cited by 42 publications

References 23 publications

Effects of Medetomidine Constant Rate Infusion on Sevoflurane Requirement, Cardiopulmonary Function, and Recovery Quality in Thoroughbred Racehorses Undergoing Arthroscopic Surgery

Effects of Medetomidine Constant Rate Infusion on Sevoflurane Requirement, Cardiopulmonary Function, and Recovery Quality in Thoroughbred Racehorses Undergoing Arthroscopic Surgery

Renal Replacement Therapy in Healthy Adult Horses

Influence of a constant rate infusion of dexmedetomidine on cardiopulmonary function and recovery quality in isoflurane anaesthetized horses

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